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Co-localisation of Glandular and Squamous Cell Markers in Non-small Cell Lung Cancer
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- Koyi, Hirsh (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Gavle Cent Hosp, Dept Resp Med, S-80187 Gavle, Sweden;Karolinska Inst, Stockholm, Sweden
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- Brandén, Eva (författare)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Gavle Cent Hosp, Dept Resp Med, S-80187 Gavle, Sweden;Karolinska Inst, Stockholm, Sweden
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- Kasim, Ihsan (författare)
- Gavle Cty Hosp, Dept Pathol, Gavle, Sweden
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- (creator_code:org_t)
- 2018-05-30
- 2018
- Engelska.
- Ingår i: Anticancer Research. - : Anticancer Research USA Inc.. - 0250-7005 .- 1791-7530. ; 38:6, s. 3341-3346
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Aim: Accurate classification of lung carcinomas is crucial for selecting appropriate and adequate chemotherapy treatment. In this study, glandular (adenocarcinoma), and squamous cell differentiation were examined in non-small cell lung carcinoma (NSCLC) without obvious light-microscopic signs of squamous and glandular differentiation. Materials and Methods: All lung tumours diagnosed as NSCLC (n=61), without obvious squamous or glandular features, were obtained by bronchial biopsy or core biopsy supported by computed tomography. They were diagnosed during 1996-2009, at the Department of Pathology, Gavle Hospital, Sweden. The tumours were examined immunohistochemically with antibodies against CK5/6, p63 (squamous cell markers) and carcinoembryonic antigen (CEA) (adenocarcinoma cell marker). Double immunostaining (p63/CEA) was also performed on individual tumours. Results: The tumours originated from 36 males and 25 females, aged 54-83 years. Pure squamous cell differentiation (CK5/6 positive only) occurred in 34.4% (n=21) tumours and pure adenocarcinoma cell differentiation (CEA positive only) was present in 14.9% (n=9). Tumours with both squamous and adenocarcinoma features (CK5/6 and CEA positive) were most prevalent (47.5%, n=29). Two tumours (3.3%) were negative with both stains (and also synaptophysin negative). Double immunostaining (p63/CEA) revealed that squamous and adenocarcinoma markers were co-localised in cells in certain tumours. Conclusion: Co-localisation of squamous and adenocarcinoma markers in the same tumour cell suggests that additional analyses for novel biomarkers of specific lung cancer types may subsequently lead to a refined treatment choice for patients with the goal of improving clinical outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Lung cancer
- squamous cell carcinoma
- adenocarcinoma
- CEA
- CK5/6 expression
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- Koyi, Hirsh
- Brandén, Eva
- Kasim, Ihsan
- Wilander, Erik
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