Search: WFRF:(Kelleher C) > (2010-2014) > Common variants at ...
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000 | 07644naa a2202029 4500 | |
001 | oai:DiVA.org:uu-273754 | |
003 | SwePub | |
008 | 160118s2012 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:125528731 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2737542 URI |
024 | 7 | a https://doi.org/10.1038/ng.24082 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1255287312 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Su, Zhan4 aut |
245 | 1 0 | a Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. |
264 | c 2012-09-09 | |
264 | 1 | b Springer Science and Business Media LLC,c 2012 |
338 | a print2 rdacarrier | |
520 | a Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report the first genome-wide association study on Barrett's esophagus, comprising 1,852 UK cases and 5,172 UK controls in the discovery stage and 5,986 cases and 12,825 controls in the replication stage. Variants at two loci were associated with disease risk: chromosome 6p21, rs9257809 (Pcombined=4.09×10(-9); odds ratio (OR)=1.21, 95% confidence interval (CI)=1.13-1.28), within the major histocompatibility complex locus, and chromosome 16q24, rs9936833 (Pcombined=2.74×10(-10); OR=1.14, 95% CI=1.10-1.19), for which the closest protein-coding gene is FOXF1, which is implicated in esophageal development and structure. We found evidence that many common variants of small effect contribute to genetic susceptibility to Barrett's esophagus and that SNP alleles predisposing to obesity also increase risk for Barrett's esophagus. | |
700 | 1 | a Gay, Laura J4 aut |
700 | 1 | a Strange, Amy4 aut |
700 | 1 | a Palles, Claire4 aut |
700 | 1 | a Band, Gavin4 aut |
700 | 1 | a Whiteman, David C4 aut |
700 | 1 | a Lescai, Francesco4 aut |
700 | 1 | a Langford, Cordelia4 aut |
700 | 1 | a Nanji, Manoj4 aut |
700 | 1 | a Edkins, Sarah4 aut |
700 | 1 | a van der Winkel, Anouk4 aut |
700 | 1 | a Levine, David4 aut |
700 | 1 | a Sasieni, Peter4 aut |
700 | 1 | a Bellenguez, Céline4 aut |
700 | 1 | a Howarth, Kimberley4 aut |
700 | 1 | a Freeman, Colin4 aut |
700 | 1 | a Trudgill, Nigel4 aut |
700 | 1 | a Tucker, Art T4 aut |
700 | 1 | a Pirinen, Matti4 aut |
700 | 1 | a Peppelenbosch, Maikel P4 aut |
700 | 1 | a van der Laan, Luc J W4 aut |
700 | 1 | a Kuipers, Ernst J4 aut |
700 | 1 | a Drenth, Joost P H4 aut |
700 | 1 | a Peters, Wilbert H4 aut |
700 | 1 | a Reynolds, John V4 aut |
700 | 1 | a Kelleher, Dermot P4 aut |
700 | 1 | a McManus, Ross4 aut |
700 | 1 | a Grabsch, Heike4 aut |
700 | 1 | a Prenen, Hans4 aut |
700 | 1 | a Bisschops, Raf4 aut |
700 | 1 | a Krishnadath, Kausila4 aut |
700 | 1 | a Siersema, Peter D4 aut |
700 | 1 | a van Baal, Jantine W P M4 aut |
700 | 1 | a Middleton, Marku Karolinska Institutet4 aut |
700 | 1 | a Petty, Russell4 aut |
700 | 1 | a Gillies, Richard4 aut |
700 | 1 | a Burch, Nicola4 aut |
700 | 1 | a Bhandari, Pradeep4 aut |
700 | 1 | a Paterson, Stuart4 aut |
700 | 1 | a Edwards, Cathryn4 aut |
700 | 1 | a Penman, Ian4 aut |
700 | 1 | a Vaidya, Kishor4 aut |
700 | 1 | a Ang, Yeng4 aut |
700 | 1 | a Murray, Iain4 aut |
700 | 1 | a Patel, Praful4 aut |
700 | 1 | a Ye, Weimin4 aut |
700 | 1 | a Mullins, Paul4 aut |
700 | 1 | a Wu, Anna H4 aut |
700 | 1 | a Bird, Nigel C4 aut |
700 | 1 | a Dallal, Helen4 aut |
700 | 1 | a Shaheen, Nicholas J4 aut |
700 | 1 | a Murray, Liam J4 aut |
700 | 1 | a Koss, Konrad4 aut |
700 | 1 | a Bernstein, Leslie4 aut |
700 | 1 | a Romero, Yvonne4 aut |
700 | 1 | a Hardie, Laura J4 aut |
700 | 1 | a Zhang, Rui4 aut |
700 | 1 | a Winter, Helen4 aut |
700 | 1 | a Corley, Douglas A4 aut |
700 | 1 | a Panter, Simon4 aut |
700 | 1 | a Risch, Harvey A4 aut |
700 | 1 | a Reid, Brian J4 aut |
700 | 1 | a Sargeant, Ian4 aut |
700 | 1 | a Gammon, Marilie D4 aut |
700 | 1 | a Smart, Howard4 aut |
700 | 1 | a Dhar, Anjan4 aut |
700 | 1 | a McMurtry, Hugh4 aut |
700 | 1 | a Ali, Haythem4 aut |
700 | 1 | a Liu, Geoffrey4 aut |
700 | 1 | a Casson, Alan G4 aut |
700 | 1 | a Chow, Wong-Ho4 aut |
700 | 1 | a Rutter, Matt4 aut |
700 | 1 | a Tawil, Ashref4 aut |
700 | 1 | a Morris, Danielle4 aut |
700 | 1 | a Nwokolo, Chuka4 aut |
700 | 1 | a Isaacs, Peter4 aut |
700 | 1 | a Rodgers, Colin4 aut |
700 | 1 | a Ragunath, Krish4 aut |
700 | 1 | a MacDonald, Chris4 aut |
700 | 1 | a Haigh, Chris4 aut |
700 | 1 | a Monk, David4 aut |
700 | 1 | a Davies, Gareth4 aut |
700 | 1 | a Wajed, Saj4 aut |
700 | 1 | a Johnston, David4 aut |
700 | 1 | a Gibbons, Michael4 aut |
700 | 1 | a Cullen, Sue4 aut |
700 | 1 | a Church, Nicholas4 aut |
700 | 1 | a Langley, Ruth4 aut |
700 | 1 | a Griffin, Michael4 aut |
700 | 1 | a Alderson, Derek4 aut |
700 | 1 | a Deloukas, Panos4 aut |
700 | 1 | a Hunt, Sarah E4 aut |
700 | 1 | a Gray, Emma4 aut |
700 | 1 | a Dronov, Serge4 aut |
700 | 1 | a Potter, Simon C4 aut |
700 | 1 | a Tashakkori-Ghanbaria, Avazeh4 aut |
700 | 1 | a Anderson, Mark4 aut |
700 | 1 | a Brooks, Claire4 aut |
700 | 1 | a Blackwell, Jenefer M4 aut |
700 | 1 | a Bramon, Elvira4 aut |
700 | 1 | a Brown, Matthew A4 aut |
700 | 1 | a Casas, Juan P4 aut |
700 | 1 | a Corvin, Aiden4 aut |
700 | 1 | a Duncanson, Audrey4 aut |
700 | 1 | a Markus, Hugh S4 aut |
700 | 1 | a Mathew, Christopher G4 aut |
700 | 1 | a Palmer, Colin N A4 aut |
700 | 1 | a Plomin, Robert4 aut |
700 | 1 | a Rautanen, Anna4 aut |
700 | 1 | a Sawcer, Stephen J4 aut |
700 | 1 | a Trembath, Richard C4 aut |
700 | 1 | a Viswanathan, Ananth C4 aut |
700 | 1 | a Wood, Nicholas4 aut |
700 | 1 | a Trynka, Gosia4 aut |
700 | 1 | a Wijmenga, Cisca4 aut |
700 | 1 | a Cazier, Jean-Baptiste4 aut |
700 | 1 | a Atherfold, Paul4 aut |
700 | 1 | a Nicholson, Anna M4 aut |
700 | 1 | a Gellatly, Nichola L4 aut |
700 | 1 | a Glancy, Deborah4 aut |
700 | 1 | a Cooper, Sheldon C4 aut |
700 | 1 | a Cunningham, David4 aut |
700 | 1 | a Lind, Tore4 aut |
700 | 1 | a Hapeshi, Julie4 aut |
700 | 1 | a Ferry, David4 aut |
700 | 1 | a Rathbone, Barrie4 aut |
700 | 1 | a Brown, Julia4 aut |
700 | 1 | a Love, Sharon4 aut |
700 | 1 | a Attwood, Stephen4 aut |
700 | 1 | a MacGregor, Stuart4 aut |
700 | 1 | a Watson, Peter4 aut |
700 | 1 | a Sanders, Scott4 aut |
700 | 1 | a Ek, Weronica4 aut |
700 | 1 | a Harrison, Rebecca F4 aut |
700 | 1 | a Moayyedi, Paul4 aut |
700 | 1 | a de Caestecker, John4 aut |
700 | 1 | a Barr, Hugh4 aut |
700 | 1 | a Stupka, Elia4 aut |
700 | 1 | a Vaughan, Thomas L4 aut |
700 | 1 | a Peltonen, Leena4 aut |
700 | 1 | a Spencer, Chris C A4 aut |
700 | 1 | a Tomlinson, Ian4 aut |
700 | 1 | a Donnelly, Peter4 aut |
700 | 1 | a Jankowski, Janusz A Z4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 44:10q 44:10x 1061-4036x 1546-1718 |
856 | 4 | u https://europepmc.org/articles/pmc3459818?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-273754 |
856 | 4 8 | u https://doi.org/10.1038/ng.2408 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:125528731 |
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