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Genome-wide meta-an...
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
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Estrada, Karol (author)
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Styrkarsdottir, Unnur (author)
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Evangelou, Evangelos (author)
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show more...
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Hsu, Yi-Hsiang (author)
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Duncan, Emma L (author)
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Ntzani, Evangelia E (author)
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Oei, Ling (author)
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Albagha, Omar M E (author)
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Amin, Najaf (author)
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Kemp, John P (author)
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Koller, Daniel L (author)
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Li, Guo (author)
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Liu, Ching-Ti (author)
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Minster, Ryan L (author)
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Moayyeri, Alireza (author)
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- Vandenput, Liesbeth, 1974 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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Willner, Dana (author)
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Xiao, Su-Mei (author)
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Yerges-Armstrong, Laura M (author)
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Zheng, Hou-Feng (author)
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Alonso, Nerea (author)
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- Eriksson, Joel (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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Kammerer, Candace M (author)
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Kaptoge, Stephen K (author)
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Leo, Paul J (author)
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Thorleifsson, Gudmar (author)
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Wilson, Scott G (author)
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Wilson, James F (author)
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Aalto, Ville (author)
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Alen, Markku (author)
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Aragaki, Aaron K (author)
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Aspelund, Thor (author)
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Center, Jacqueline R (author)
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Dailiana, Zoe (author)
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Duggan, David J (author)
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Garcia, Melissa (author)
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Garcia-Giralt, Natalia (author)
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Giroux, Sylvie (author)
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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Hocking, Lynne J (author)
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Husted, Lise Bjerre (author)
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Jameson, Karen A (author)
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Khusainova, Rita (author)
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Kim, Ghi Su (author)
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Kooperberg, Charles (author)
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Koromila, Theodora (author)
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Kruk, Marcin (author)
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Laaksonen, Marika (author)
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Lacroix, Andrea Z (author)
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Lee, Seung Hun (author)
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Leung, Ping C (author)
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Lewis, Joshua R (author)
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Masi, Laura (author)
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Mencej-Bedrac, Simona (author)
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Nguyen, Tuan V (author)
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Nogues, Xavier (author)
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Patel, Millan S (author)
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Prezelj, Janez (author)
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Rose, Lynda M (author)
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Scollen, Serena (author)
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Siggeirsdottir, Kristin (author)
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Smith, Albert V (author)
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- Svensson, Olle (author)
- Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap
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Trompet, Stella (author)
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Trummer, Olivia (author)
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- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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Woo, Jean (author)
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Zhu, Kun (author)
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Balcells, Susana (author)
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Brandi, Maria Luisa (author)
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Buckley, Brendan M (author)
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Cheng, Sulin (author)
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Christiansen, Claus (author)
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Cooper, Cyrus (author)
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Dedoussis, George (author)
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Ford, Ian (author)
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Frost, Morten (author)
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Goltzman, David (author)
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Gonzalez-Macias, Jesus (author)
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Kähönen, Mika (author)
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- Karlsson, Magnus (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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Khusnutdinova, Elza (author)
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Koh, Jung-Min (author)
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Kollia, Panagoula (author)
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Langdahl, Bente Lomholt (author)
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Leslie, William D (author)
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Lips, Paul (author)
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- Ljunggren, Östen (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Metabola bensjukdomar
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Lorenc, Roman S (author)
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Marc, Janja (author)
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- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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Obermayer-Pietsch, Barbara (author)
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Olmos, José M (author)
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- Pettersson-Kymmer, Ulrika (author)
- Umeå universitet,Klinisk farmakologi
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Reid, David M (author)
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Riancho, José A (author)
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Ridker, Paul M (author)
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Rousseau, François (author)
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Slagboom, P Eline (author)
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Tang, Nelson L S (author)
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Urreizti, Roser (author)
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Van Hul, Wim (author)
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Viikari, Jorma (author)
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Zarrabeitia, María T (author)
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Aulchenko, Yurii S (author)
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Castano-Betancourt, Martha (author)
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Grundberg, Elin (author)
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Herrera, Lizbeth (author)
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Ingvarsson, Thorvaldur (author)
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Johannsdottir, Hrefna (author)
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Kwan, Tony (author)
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Li, Rui (author)
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Luben, Robert (author)
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Medina-Gomez, Carolina (author)
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Palsson, Stefan Th (author)
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Reppe, Sjur (author)
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Rotter, Jerome I (author)
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Sigurdsson, Gunnar (author)
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van Meurs, Joyce B J (author)
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Verlaan, Dominique (author)
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Williams, Frances M K (author)
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Wood, Andrew R (author)
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Zhou, Yanhua (author)
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Gautvik, Kaare M (author)
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Pastinen, Tomi (author)
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Raychaudhuri, Soumya (author)
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Cauley, Jane A (author)
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Chasman, Daniel I (author)
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Clark, Graeme R (author)
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Cummings, Steven R (author)
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Danoy, Patrick (author)
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Dennison, Elaine M (author)
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Eastell, Richard (author)
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Eisman, John A (author)
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Gudnason, Vilmundur (author)
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Hofman, Albert (author)
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Jackson, Rebecca D (author)
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Jones, Graeme (author)
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Jukema, J Wouter (author)
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Khaw, Kay-Tee (author)
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Lehtimäki, Terho (author)
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Liu, Yongmei (author)
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- Lorentzon, Mattias, 1970 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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McCloskey, Eugene (author)
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Mitchell, Braxton D (author)
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Nandakumar, Kannabiran (author)
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Nicholson, Geoffrey C (author)
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Oostra, Ben A (author)
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Peacock, Munro (author)
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Pols, Huibert A P (author)
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Prince, Richard L (author)
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Raitakari, Olli (author)
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Reid, Ian R (author)
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Robbins, John (author)
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Sambrook, Philip N (author)
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Sham, Pak Chung (author)
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Shuldiner, Alan R (author)
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Tylavsky, Frances A (author)
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van Duijn, Cornelia M (author)
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Wareham, Nick J (author)
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Cupples, L Adrienne (author)
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Econs, Michael J (author)
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Evans, David M (author)
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Harris, Tamara B (author)
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Kung, Annie Wai Chee (author)
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Psaty, Bruce M (author)
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Reeve, Jonathan (author)
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Spector, Timothy D (author)
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Streeten, Elizabeth A (author)
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Zillikens, M Carola (author)
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Thorsteinsdottir, Unnur (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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Karasik, David (author)
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Richards, J Brent (author)
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Brown, Matthew A (author)
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Stefansson, Kari (author)
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Uitterlinden, Andre G (author)
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Ralston, Stuart H (author)
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Ioannidis, John P A (author)
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Kiel, Douglas P (author)
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Rivadeneira, Fernando (author)
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(creator_code:org_t)
- 2012-04-15
- 2012
- English.
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In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:5, s. 491-501
- Related links:
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https://www.pure.ed....
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Keyword
- Bone Density
- genetics
- Computational Biology
- European Continental Ancestry Group
- Extracellular Matrix Proteins
- genetics
- Female
- Femur Neck
- physiopathology
- Fractures
- Bone
- genetics
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Glycoproteins
- genetics
- Humans
- Intercellular Signaling Peptides and Proteins
- genetics
- Low Density Lipoprotein Receptor-Related Protein-5
- genetics
- Lumbar Vertebrae
- physiopathology
- Male
- Mitochondrial Membrane Transport Proteins
- genetics
- Osteoporosis
- genetics
- Phosphoproteins
- genetics
- Polymorphism
- Single Nucleotide
- genetics
- Quantitative Trait Loci
- Risk Factors
- Spectrin
- genetics
- genetik
- Orthopaedics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Estrada, Karol
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Styrkarsdottir, ...
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Evangelou, Evang ...
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Hsu, Yi-Hsiang
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Duncan, Emma L
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Ntzani, Evangeli ...
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show more...
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Oei, Ling
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Albagha, Omar M ...
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Amin, Najaf
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Kemp, John P
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Koller, Daniel L
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Li, Guo
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Liu, Ching-Ti
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Minster, Ryan L
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Moayyeri, Alirez ...
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Vandenput, Liesb ...
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Willner, Dana
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Xiao, Su-Mei
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Yerges-Armstrong ...
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Zheng, Hou-Feng
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Alonso, Nerea
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Eriksson, Joel
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Kammerer, Candac ...
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Kaptoge, Stephen ...
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Leo, Paul J
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Thorleifsson, Gu ...
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Wilson, Scott G
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Wilson, James F
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Aalto, Ville
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Alen, Markku
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Aragaki, Aaron K
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Aspelund, Thor
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Center, Jacqueli ...
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Dailiana, Zoe
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Duggan, David J
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Garcia, Melissa
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Garcia-Giralt, N ...
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Giroux, Sylvie
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Hallmans, Göran
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Hocking, Lynne J
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Husted, Lise Bje ...
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Jameson, Karen A
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Khusainova, Rita
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Kim, Ghi Su
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Kooperberg, Char ...
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Koromila, Theodo ...
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Kruk, Marcin
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Laaksonen, Marik ...
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Lacroix, Andrea ...
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Lee, Seung Hun
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Leung, Ping C
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Lewis, Joshua R
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Masi, Laura
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Mencej-Bedrac, S ...
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Nguyen, Tuan V
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Nogues, Xavier
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Patel, Millan S
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Prezelj, Janez
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Rose, Lynda M
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Scollen, Serena
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Siggeirsdottir, ...
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Smith, Albert V
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Svensson, Olle
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Trompet, Stella
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Trummer, Olivia
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Mellström, Dan, ...
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Woo, Jean
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Zhu, Kun
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Balcells, Susana
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Brandi, Maria Lu ...
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Buckley, Brendan ...
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Cheng, Sulin
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Christiansen, Cl ...
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Cooper, Cyrus
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Dedoussis, Georg ...
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Ford, Ian
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Frost, Morten
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Goltzman, David
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Gonzalez-Macias, ...
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Kähönen, Mika
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Karlsson, Magnus
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Khusnutdinova, E ...
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Koh, Jung-Min
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Kollia, Panagoul ...
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Langdahl, Bente ...
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Leslie, William ...
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Lips, Paul
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Ljunggren, Östen
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Lorenc, Roman S
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Marc, Janja
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Obermayer-Pietsc ...
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Olmos, José M
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Pettersson-Kymme ...
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Reid, David M
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Riancho, José A
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Ridker, Paul M
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Rousseau, Franço ...
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Slagboom, P Elin ...
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Tang, Nelson L S
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Urreizti, Roser
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Van Hul, Wim
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Viikari, Jorma
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Zarrabeitia, Mar ...
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Aulchenko, Yurii ...
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Castano-Betancou ...
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Grundberg, Elin
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Herrera, Lizbeth
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Ingvarsson, Thor ...
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Johannsdottir, H ...
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Kwan, Tony
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Li, Rui
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Luben, Robert
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Medina-Gomez, Ca ...
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Palsson, Stefan ...
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Reppe, Sjur
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Rotter, Jerome I
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Sigurdsson, Gunn ...
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van Meurs, Joyce ...
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Verlaan, Dominiq ...
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Williams, France ...
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Wood, Andrew R
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Zhou, Yanhua
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Gautvik, Kaare M
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Pastinen, Tomi
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Raychaudhuri, So ...
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Cauley, Jane A
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Chasman, Daniel ...
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Clark, Graeme R
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Cummings, Steven ...
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Danoy, Patrick
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Dennison, Elaine ...
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Eastell, Richard
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Eisman, John A
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Gudnason, Vilmun ...
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Hofman, Albert
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Jackson, Rebecca ...
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Jones, Graeme
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Jukema, J Wouter
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Khaw, Kay-Tee
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Lehtimäki, Terho
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Liu, Yongmei
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Lorentzon, Matti ...
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McCloskey, Eugen ...
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Mitchell, Braxto ...
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Nandakumar, Kann ...
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Nicholson, Geoff ...
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Oostra, Ben A
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Peacock, Munro
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Pols, Huibert A ...
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Prince, Richard ...
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Raitakari, Olli
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Reid, Ian R
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Robbins, John
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Sambrook, Philip ...
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Sham, Pak Chung
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Shuldiner, Alan ...
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Tylavsky, France ...
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van Duijn, Corne ...
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Wareham, Nick J
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Cupples, L Adrie ...
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Econs, Michael J
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Evans, David M
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Harris, Tamara B
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Kung, Annie Wai ...
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Psaty, Bruce M
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Reeve, Jonathan
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Spector, Timothy ...
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Streeten, Elizab ...
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Zillikens, M Car ...
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Thorsteinsdottir ...
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Ohlsson, Claes, ...
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Karasik, David
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Richards, J Bren ...
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Brown, Matthew A
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Stefansson, Kari
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Uitterlinden, An ...
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Ralston, Stuart ...
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Ioannidis, John ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
- Articles in the publication
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Nature genetics
- By the university
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University of Gothenburg
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Umeå University
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Lund University
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Uppsala University