WFRF:(Klas M.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04218naa a2200697 4500 | |
| 001 | oai:gup.ub.gu.se/60703 | |
| 003 | SwePub | |
| 008 | 240528s1994 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/607032 URI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Fu, Michael,d 1963u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xfumiw |
| 245 | 1 0 | a Properties of G-protein modulated receptor-adenylyl cyclase system in myocardium of spontaneously hypertensive rats treated with adriamycin. |
| 264 | 1 | c 1994 |
| 520 | a Properties of the receptor--G protein--adenylyl cyclase system were studied in spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY) treated with adriamycin (ADR, 1 mg/kg per week) for 12 weeks. An identical dosing schedule caused a significantly greater decline in body weight gain and a marked elevation of plasma norepinephrine level in SHR than in WKY. A significant increase in the messenger RNA encoding Gi-alpha 2 was found in SHR+ADR group. The activity of the adenylyl cyclase stimulated by guanyliminodiphosphate [Gpp(NH)p] was decreased by 49% in SHR and 73% in SHR+ADR. However, stimulated activities of adenylyl cyclase by both sodium fluoride and forskolin remained unchanged. Functional level of stimulatory G-protein (Gs) as measured by reconstitution assay in sarcolemmal membrane was unaltered among different groups. Furthermore, the density of beta-adrenoceptor was significantly decreased without change of its affinity. Muscarinic receptors exhibited a three-site affinity distribution in SHR+ADR whereas other groups displayed only two-site affinity distribution. These results suggest that SHR exhibited a depressed myocardial adenylyl cyclase signaling system which may not be due to the functional uncoupling of beta-adrenoceptors from Gs but to the increased inhibitory G-protein (Gi) activity as demonstrated by the increased mRNA of Gi-alpha 2, increased inhibition of Gpp(NH)p-mediated adenylyl cyclase and the super high affinity for carbachol of the muscarinic receptors. Decreased beta-adrenoceptor density and functional alteration of Gi might be regarded as the predisposing factors for the increased susceptibility of myocardium of SHR to ADR. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a Adenylate Cyclase | |
| 653 | a physiology | |
| 653 | a Animals | |
| 653 | a Doxorubicin | |
| 653 | a pharmacology | |
| 653 | a GTP-Binding Proteins | |
| 653 | a genetics | |
| 653 | a physiology | |
| 653 | a Heart | |
| 653 | a physiopathology | |
| 653 | a Hypertension | |
| 653 | a physiopathology | |
| 653 | a Male | |
| 653 | a Myocardium | |
| 653 | a chemistry | |
| 653 | a Norepinephrine | |
| 653 | a blood | |
| 653 | a RNA | |
| 653 | a Messenger | |
| 653 | a analysis | |
| 653 | a Rats | |
| 653 | a Rats | |
| 653 | a Inbred SHR | |
| 653 | a Rats | |
| 653 | a Inbred WKY | |
| 653 | a Receptors | |
| 653 | a Adrenergic | |
| 653 | a beta | |
| 653 | a physiology | |
| 653 | a Receptors | |
| 653 | a Muscarinic | |
| 653 | a analysis | |
| 653 | a Sarcolemma | |
| 653 | a chemistry | |
| 700 | 1 | a Matoba, M4 aut |
| 700 | 1 | a Liang, Qi-Mingu Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut |
| 700 | 1 | a Sjögren, Klas-Göranu Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut |
| 700 | 1 | a Hjalmarson, Åke,d 1937u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xhjala |
| 710 | 2 | a Göteborgs universitetb Wallenberglaboratoriet4 org |
| 773 | 0 | t International journal of cardiologyg 44:1, s. 9-18q 44:1<9-18x 0167-5273 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/60703 |
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