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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 15242naa a2204621 4500 | |
| 001 | oai:gup.ub.gu.se/296136 | |
| 003 | SwePub | |
| 008 | 240528s2020 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:143572790 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2961362 URI |
| 024 | 7 | a https://doi.org/10.1038/s41588-020-0610-92 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1435727902 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bryois, J.u Karolinska Institutet4 aut |
| 245 | 1 0 | a Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease |
| 264 | c 2020-04-27 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2020 |
| 520 | a Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
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| 653 | a cholinergic nerve cell | |
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| 653 | a single cell RNA seq | |
| 653 | a transcriptomics | |
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| 700 | 1 | a Skene, N. G.4 aut |
| 700 | 1 | a Hansen, T. F.4 aut |
| 700 | 1 | a Kogelman, L. J. A.4 aut |
| 700 | 1 | a Watson, H. J.4 aut |
| 700 | 1 | a Liu, Z.4 aut |
| 700 | 1 | a Adan, Roger A. H.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xadaro |
| 700 | 1 | a Alfredsson, L.4 aut |
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| 700 | 1 | a Hjerling-Leffler, J.4 aut |
| 700 | 1 | a Sullivan, P. F.4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi4 org |
| 773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 52:5, s. 482-493q 52:5<482-493x 1061-4036x 1546-1718 |
| 856 | 4 | u https://pure.rug.nl/ws/files/126597630/74135160_5593569_Bryois_et_al_Nature_genetics_2020.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/296136 |
| 856 | 4 8 | u https://doi.org/10.1038/s41588-020-0610-9 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:143572790 |
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- Bryois, J.
- Skene, N. G.
- Hansen, T. F.
- Kogelman, L. J. ...
- Watson, H. J.
- Liu, Z.
- visa fler...
- Adan, Roger A. H ...
- Alfredsson, L.
- Ando, T.
- Andreassen, O.
- Baker, J.
- Bergen, A.
- Berrettini, W.
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- Boden, J.
- Boehm, I.
- Boni, C.
- Boraska Perica, ...
- Brandt, H.
- Breen, G.
- Buehren, K.
- Bulik, C.
- Burghardt, R.
- Cassina, M.
- Cichon, S.
- Clementi, M.
- Coleman, J.
- Cone, R.
- Courtet, P.
- Crawford, S.
- Crow, S.
- Crowley, J.
- Danner, U.
- Davis, O.
- de Zwaan, M.
- Dedoussis, G.
- Degortes, D.
- DeSocio, J.
- Dick, D.
- Dikeos, D.
- Dina, C.
- Dmitrzak-Weglarz ...
- Docampo Martinez ...
- Duncan, L.
- Egberts, K.
- Ehrlich, S.
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- Esko, T.
- Estivill, X.
- Farmer, A.
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- Fichter, M.
- Fischer, K.
- Föcker, M.
- Foretova, L.
- Forstner, A.
- Forzan, M.
- Franklin, C.
- Gallinger, S.
- Gaspar, H.
- Giegling, I.
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- Gonidakis, F.
- Gordon, S.
- Gorwood, P.
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- Grove, J.
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- Landén, M.
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- Le Hellard, S.
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- Levitan, R.
- Li, D.
- Lichtenstein, P.
- Lilenfeld, L.
- Lin, B. D.
- Lissowska, J.
- Luykx, J.
- Magistretti, P.
- Maj, M.
- Mannik, K.
- Marsal, S.
- Marshall, C.
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- Mattheisen, M.
- Mattingsdal, M.
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- McGuffin, P.
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