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  • Styrkarsdottir, UnnurdeCODE Genetics (author)

GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-05-03
  • Springer Science and Business Media LLC,2019

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:1dcd3cc7-b010-4fc7-b450-49acaa552500
  • https://lup.lub.lu.se/record/1dcd3cc7-b010-4fc7-b450-49acaa552500URI
  • https://doi.org/10.1038/s41467-019-09860-0DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Bone area is one measure of bone size that is easily derived from dual-energy X-ray absorptiometry (DXA) scans. In a GWA study of DXA bone area of the hip and lumbar spine (N ≥ 28,954), we find thirteen independent association signals at twelve loci that replicate in samples of European and East Asian descent (N = 13,608 – 21,277). Eight DXA area loci associate with osteoarthritis, including rs143384 in GDF5 and a missense variant in COL11A1 (rs3753841). The strongest DXA area association is with rs11614913[T] in the microRNA MIR196A2 gene that associates with lumbar spine area (P = 2.3 × 10 −42 , β = −0.090) and confers risk of hip fracture (P = 1.0 × 10 −8 , OR = 1.11). We demonstrate that the risk allele is less efficient in repressing miR-196a-5p target genes. We also show that the DXA area measure contributes to the risk of hip fracture independent of bone density.

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  • Gunnarsdottir, KristbjorgdeCODE Genetics (author)
  • Thorleifsson, GudmardeCODE Genetics (author)
  • Lund, Sigrun H.deCODE Genetics,University of Iceland (author)
  • Stefansdottir, LiljadeCODE Genetics (author)
  • Juliusson, KristinndeCODE Genetics (author)
  • Agustsdottir, Arna B.deCODE Genetics (author)
  • Zink, FloriandeCODE Genetics (author)
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  • Ivarsdottir, Erna V.deCODE Genetics (author)
  • Benonisdottir, StefaniadeCODE Genetics (author)
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  • Gylfason, ArnaldurdeCODE Genetics (author)
  • Norland, KristjandeCODE Genetics (author)
  • Trajanoska, KaterinaErasmus University Medical Center (author)
  • Boer, Cindy G.Erasmus University Medical Center (author)
  • Southam, LorraineWellcome Trust Centre for Human Genetics,Wellcome Trust Sanger Institute (author)
  • Leung, Jason C.S.Chinese University of Hong Kong (author)
  • Tang, Nelson L.S.Chinese University of Hong Kong (author)
  • Kwok, Timothy C.Y.Prince of Wales Hospital Hong Kong,Chinese University of Hong Kong (author)
  • Lee, Jenny S.W.Alice Ho Miu Ling Nethersole Hospital,Chinese University of Hong Kong (author)
  • Ho, Suzanne C.Chinese University of Hong Kong (author)
  • Byrjalsen, IngerNordic Bioscience AS (author)
  • Center, Jacqueline R.Garvan Institute of Medical Research,University of Notre Dame Australia,University of New South Wales (author)
  • Lee, Seung HunUniversity of Ulsan (author)
  • Koh, Jung MinUniversity of Ulsan (author)
  • Lohmander, L. StefanLund University,Lunds universitet,Lund OsteoArthritis Division - Nedbrytning av ledbrosk: en biologisk process som leder till artros,Forskargrupper vid Lunds universitet,Lund OsteoArthritis Division - Molecular marker research group,Lund University Research Groups(Swepub:lu)ort-slo (author)
  • Ho-Pham, Lan T.Ton Duc Thang University (author)
  • Nguyen, Tuan V.University of New South Wales,University of Technology Sydney,Garvan Institute of Medical Research (author)
  • Eisman, John A.Garvan Institute of Medical Research,University of Notre Dame Australia,University of New South Wales (author)
  • Woo, JeanChinese University of Hong Kong (author)
  • Leung, Ping C.Chinese University of Hong Kong (author)
  • Loughlin, JohnUniversity of Newcastle upon Tyne (author)
  • Zeggini, EleftheriaHelmholtz Zentrum München,Wellcome Trust Sanger Institute (author)
  • Christiansen, ClausNordic Bioscience AS (author)
  • Rivadeneira, FernandoErasmus University Medical Center (author)
  • van Meurs, JoyceErasmus University Medical Center (author)
  • Uitterlinden, Andre G.Erasmus University Medical Center (author)
  • Mogensen, BrynjolfurUniversity of Iceland,National University Hospital of Iceland (author)
  • Jonsson, HelgiNational University Hospital of Iceland,University of Iceland (author)
  • Ingvarsson, ThorvaldurUniversity of Akureyri,Akureyri Central Hospital,University of Iceland(Swepub:lu)extLU-875 (author)
  • Sigurdsson, GunnarUniversity of Iceland,National University Hospital of Iceland (author)
  • Benediktsson, RafnNational University Hospital of Iceland,University of Iceland (author)
  • Sulem, PatrickdeCODE Genetics (author)
  • Jonsdottir, IngileifUniversity of Iceland,National University Hospital of Iceland,deCODE Genetics (author)
  • Masson, GislideCODE Genetics (author)
  • Holm, HilmadeCODE Genetics (author)
  • Norddahl, Gudmundur L.deCODE Genetics (author)
  • Thorsteinsdottir, UnnurdeCODE Genetics,University of Iceland (author)
  • Gudbjartsson, Daniel F.deCODE Genetics,University of Iceland (author)
  • Stefansson, KarideCODE Genetics,University of Iceland (author)
  • deCODE GeneticsUniversity of Iceland (creator_code:org_t)

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  • In:Nature Communications: Springer Science and Business Media LLC10:12041-1723

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