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Sökning: WFRF:(Koh Jung Min) > (2019) > GWAS of bone size y...

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FältnamnIndikatorerMetadata
00006778naa a2200937 4500
001oai:lup.lub.lu.se:1dcd3cc7-b010-4fc7-b450-49acaa552500
003SwePub
008190520s2019 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/1dcd3cc7-b010-4fc7-b450-49acaa5525002 URI
0247 a https://doi.org/10.1038/s41467-019-09860-02 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Styrkarsdottir, Unnuru deCODE Genetics4 aut
2451 0a GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures
264 c 2019-05-03
264 1b Springer Science and Business Media LLC,c 2019
520 a Bone area is one measure of bone size that is easily derived from dual-energy X-ray absorptiometry (DXA) scans. In a GWA study of DXA bone area of the hip and lumbar spine (N ≥ 28,954), we find thirteen independent association signals at twelve loci that replicate in samples of European and East Asian descent (N = 13,608 – 21,277). Eight DXA area loci associate with osteoarthritis, including rs143384 in GDF5 and a missense variant in COL11A1 (rs3753841). The strongest DXA area association is with rs11614913[T] in the microRNA MIR196A2 gene that associates with lumbar spine area (P = 2.3 × 10 −42 , β = −0.090) and confers risk of hip fracture (P = 1.0 × 10 −8 , OR = 1.11). We demonstrate that the risk allele is less efficient in repressing miR-196a-5p target genes. We also show that the DXA area measure contributes to the risk of hip fracture independent of bone density.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng
7001 a Stefansson, Olafur A.u deCODE Genetics4 aut
7001 a Gunnarsdottir, Kristbjorgu deCODE Genetics4 aut
7001 a Thorleifsson, Gudmaru deCODE Genetics4 aut
7001 a Lund, Sigrun H.u deCODE Genetics,University of Iceland4 aut
7001 a Stefansdottir, Liljau deCODE Genetics4 aut
7001 a Juliusson, Kristinnu deCODE Genetics4 aut
7001 a Agustsdottir, Arna B.u deCODE Genetics4 aut
7001 a Zink, Florianu deCODE Genetics4 aut
7001 a Halldorsson, Gisli H.u deCODE Genetics4 aut
7001 a Ivarsdottir, Erna V.u deCODE Genetics4 aut
7001 a Benonisdottir, Stefaniau deCODE Genetics4 aut
7001 a Jonsson, Hakonu deCODE Genetics4 aut
7001 a Gylfason, Arnalduru deCODE Genetics4 aut
7001 a Norland, Kristjanu deCODE Genetics4 aut
7001 a Trajanoska, Katerinau Erasmus University Medical Center4 aut
7001 a Boer, Cindy G.u Erasmus University Medical Center4 aut
7001 a Southam, Lorraineu Wellcome Trust Centre for Human Genetics,Wellcome Trust Sanger Institute4 aut
7001 a Leung, Jason C.S.u Chinese University of Hong Kong4 aut
7001 a Tang, Nelson L.S.u Chinese University of Hong Kong4 aut
7001 a Kwok, Timothy C.Y.u Prince of Wales Hospital Hong Kong,Chinese University of Hong Kong4 aut
7001 a Lee, Jenny S.W.u Alice Ho Miu Ling Nethersole Hospital,Chinese University of Hong Kong4 aut
7001 a Ho, Suzanne C.u Chinese University of Hong Kong4 aut
7001 a Byrjalsen, Ingeru Nordic Bioscience AS4 aut
7001 a Center, Jacqueline R.u Garvan Institute of Medical Research,University of Notre Dame Australia,University of New South Wales4 aut
7001 a Lee, Seung Hunu University of Ulsan4 aut
7001 a Koh, Jung Minu University of Ulsan4 aut
7001 a Lohmander, L. Stefanu Lund University,Lunds universitet,Lund OsteoArthritis Division - Nedbrytning av ledbrosk: en biologisk process som leder till artros,Forskargrupper vid Lunds universitet,Lund OsteoArthritis Division - Molecular marker research group,Lund University Research Groups4 aut0 (Swepub:lu)ort-slo
7001 a Ho-Pham, Lan T.u Ton Duc Thang University4 aut
7001 a Nguyen, Tuan V.u University of New South Wales,University of Technology Sydney,Garvan Institute of Medical Research4 aut
7001 a Eisman, John A.u Garvan Institute of Medical Research,University of Notre Dame Australia,University of New South Wales4 aut
7001 a Woo, Jeanu Chinese University of Hong Kong4 aut
7001 a Leung, Ping C.u Chinese University of Hong Kong4 aut
7001 a Loughlin, Johnu University of Newcastle upon Tyne4 aut
7001 a Zeggini, Eleftheriau Helmholtz Zentrum München,Wellcome Trust Sanger Institute4 aut
7001 a Christiansen, Clausu Nordic Bioscience AS4 aut
7001 a Rivadeneira, Fernandou Erasmus University Medical Center4 aut
7001 a van Meurs, Joyceu Erasmus University Medical Center4 aut
7001 a Uitterlinden, Andre G.u Erasmus University Medical Center4 aut
7001 a Mogensen, Brynjolfuru University of Iceland,National University Hospital of Iceland4 aut
7001 a Jonsson, Helgiu National University Hospital of Iceland,University of Iceland4 aut
7001 a Ingvarsson, Thorvalduru University of Akureyri,Akureyri Central Hospital,University of Iceland4 aut0 (Swepub:lu)extLU-875
7001 a Sigurdsson, Gunnaru University of Iceland,National University Hospital of Iceland4 aut
7001 a Benediktsson, Rafnu National University Hospital of Iceland,University of Iceland4 aut
7001 a Sulem, Patricku deCODE Genetics4 aut
7001 a Jonsdottir, Ingileifu University of Iceland,National University Hospital of Iceland,deCODE Genetics4 aut
7001 a Masson, Gisliu deCODE Genetics4 aut
7001 a Holm, Hilmau deCODE Genetics4 aut
7001 a Norddahl, Gudmundur L.u deCODE Genetics4 aut
7001 a Thorsteinsdottir, Unnuru deCODE Genetics,University of Iceland4 aut
7001 a Gudbjartsson, Daniel F.u deCODE Genetics,University of Iceland4 aut
7001 a Stefansson, Kariu deCODE Genetics,University of Iceland4 aut
7102 a deCODE Geneticsb University of Iceland4 org
7730 t Nature Communicationsd : Springer Science and Business Media LLCg 10:1q 10:1x 2041-1723
8564 u http://dx.doi.org/10.1038/s41467-019-09860-0x freey FULLTEXT
8564 u https://www.nature.com/articles/s41467-019-09860-0.pdf
8564 8u https://lup.lub.lu.se/record/1dcd3cc7-b010-4fc7-b450-49acaa552500
8564 8u https://doi.org/10.1038/s41467-019-09860-0

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