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Sökning: WFRF:(Kopylov Uri) > (2023) > Idiopathic Thromboc...

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FältnamnIndikatorerMetadata
00006484naa a2200481 4500
001oai:DiVA.org:oru-102520
003SwePub
008221205s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1025202 URI
0247 a https://doi.org/10.1093/ecco-jcc/jjac1792 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mahajna, Husseinu Department of Gastroenterology, Sheba Medical Center, Ramat-Gan, Israel4 aut
2451 0a Idiopathic Thrombocytopenic Purpura associated with Inflammatory Bowel Disease :b a multi-centre ECCO CONFER case series
264 c 2022-12-02
264 1b Oxford University Press,c 2023
338 a print2 rdacarrier
520 a BACKGROUND: Idiopathic Thrombocytopenic Purpura (ITP) is an acquired haematological disorder with an incidence of 1 to 6 per 100,000/year. ITP and inflammatory bowel disease (IBD) comorbidity has been reported in the literature, but insights regarding the course, outcome and optimal management are limited by its rarity. The current study aimed to evaluate the clinical presentation and outcome of ITP in patients with IBD.METHODS: This multicentre retrospective case series was performed as part of the ECCO Collaborative Network of Exceptionally Rare case reports (CONFER) project. Cases of patients with ITP and IBD were collected by participating investigators. Clinical data were recorded in a standardised collection form.RESULTS: This report includes 32 patients with concurrent ITP and IBD:10 were females, median age was 32.0 [interquartile range (IQR) 20.5-39.5]. 14 patients had a diagnosis of Crohn's disease (CD) and the other 18 had of ulcerative colitis (UC). The diagnosis of IBD preceded the ITP in 26 patients (median time between diagnoses was 7.0 years [IQR, 1.5-9.5]). Among those patients, 17 patients were in clinical remission at ITP diagnosis. 13 patients were treated with mesalamine, 4 with oral corticosteroids, 1 with rectal corticosteroids, 2 with azathioprine, and 5 with anti-TNF agents. The median platelet count was 35,000/mmc (IQR, 10,000-70,000). 8 patients had rectal bleeding, 13 had skin purpura, 3 had epistaxis, 6 had mucosal petechiae, and 13 were asymptomatic. Regarding ITP treatment, 19 were treated with corticosteroids, 1 with Anti-RhD immunoglobulin, 12 with intravenous immunoglobulins (IVIG), 4 with thrombopoietin, 3 with rituximab and 6 patients eventually required splenectomy. 10 patients needed no treatment directed to the ITP.Three patients required colectomy during term long follow-up, due to IBD or cancer and not to massive bleeding as a complication of ITP. One patient of eight patients who presented with rectal bleeding required splenectomy, and none required urgent colectomy. Two patients died during the follow-up, one of them due to bleeding complication located in the upper gastrointestinal tract.Median follow-up time was 6.5 years [IQR, 3-10]. With long-term follow-up, all patients had platelet count above 50,000/mmc, and 24 were in IBD clinical remission.CONCLUSION: Most ITP cases in this case series occurred after the IBD diagnosis and responded well to regular ITP treatment. The course of the ITP in the IBD patients follows an expected course, including response to medical therapy and low rates of splenectomy.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
653 a IBD
653 a ITP
7001 a Verstockt, Bramu Dpt. Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Dpt. Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium4 aut
7001 a Bergemalm, Daniel,d 1977-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology4 aut0 (Swepub:oru)dbm
7001 a Castiglione, Fabianau Department of Clinical Medicine and Surgery, "Federico II" University of Naples, Naples, Italy4 aut
7001 a Rodríguez-Moranta, Fransiscou Gastroenterology Department, Hospital Universitario Bellvitge, Barcelona, Spain4 aut
7001 a Savarino, Edoardo Vincenzou Department of Surgery, Oncology and Gastroenterology, University of Padua, Italy; Gastroenterology Unit, Azienda Ospedale Università di Padova, Padua, Italy4 aut
7001 a Hoentjen, Franku Department of Gastroenterology, Radboud University Medical Center, Nijmegen, The Netherlands; Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Canada4 aut
7001 a Bessissow, Talatu Department of Gastroenterology, Royal Victoria Hospital, McGill University Health Center, Montreal, QC, Canada4 aut
7001 a Pokryszka, Jagodau Department of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria4 aut
7001 a Cremer, Annelineu Department of Gastroenterology, Erasme University Hospital, ULB, Brussels, Belgium4 aut
7001 a Eder, Piotru Department of Gastroenterology, Dietetics, and Internal Medicine, Poznań University of Medical Sciences, Poland4 aut
7001 a Truyens, Marieu IBD Unit, Department of Gastroenterology, Ghent University Hospital, 9000 Ghent, Belgium4 aut
7001 a Yerushalmy-Feler, Anatu Paediatric Gastroenterology Institute, "Dana-Dwek" Children's Hospital, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel4 aut
7001 a Garcia, Maria Joseu IBD Unit. Gastroenterology and Hepatology Department, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain4 aut
7001 a Kopylov, Uriu Department of Gastroenterology, Tel-Hashomer Sheba Medical Center, Ramat Gan, and Sackler Medical School, Tel Aviv, Israel4 aut
7102 a Department of Gastroenterology, Sheba Medical Center, Ramat-Gan, Israelb Dpt. Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Dpt. Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium4 org
7730 t Journal of Crohn's & Colitisd : Oxford University Pressg 17:5, s. 722-727q 17:5<722-727x 1873-9946x 1876-4479
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-102520
8564 8u https://doi.org/10.1093/ecco-jcc/jjac179

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