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WFRF:(Korat Andres V. Ardisson)
 

Sökning: WFRF:(Korat Andres V. Ardisson) > (2021) > n-3 Fatty Acid Biom...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009204naa a2200805 4500
001oai:DiVA.org:uu-446186
003SwePub
008210617s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4461862 URI
0247 a https://doi.org/10.2337/dc20-24262 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Qian, Franku Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard Med Sch, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.4 aut
2451 0a n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes :b An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies
264 c 2021-03-03
264 1b American Diabetes Association,c 2021
338 a print2 rdacarrier
520 a OBJECTIVE Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis.RESEARCH DESIGN AND METHODS For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a pre-specified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis.RESULTS A total of 16,693 incident T2D cases were identified during follow-up (median follow-up ranging from 2.5 to 21.2 years). In pooled multivariable analysis, per interquintile range (difference between the 90th and 10th percentiles for each fatty acid), EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively (all P < 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses.CONCLUSIONS Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Korat, Andres V. Ardissonu Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut
7001 a Imamura, Fumiakiu Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.4 aut
7001 a Marklund, Mattiu Uppsala universitet,Klinisk nutrition och metabolism,Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.;Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.4 aut0 (Swepub:uu)matma701
7001 a Tintle, Nathanu Dordt Univ, Dept Math & Stat, Sioux Ctr, SD USA.;Fatty Acid Res Inst, Sioux Falls, SD USA.4 aut
7001 a Virtanen, Jyrki K.u Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.4 aut
7001 a Zhou, Xiau Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.4 aut
7001 a Bassett, Julie K.u Canc Council Victoria, Melbourne, Vic, Australia.4 aut
7001 a Lai, Heidiu Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.;Imperial Coll London, London, England.4 aut
7001 a Hirakawa, Yoichirou Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan.4 aut
7001 a Chien, Kuo-Liongu Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan.;Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.4 aut
7001 a Wood, Alexis C.u USDA ARS, Childrens Nutr Res Ctr, Houston, TX USA.4 aut
7001 a Lankinen, Mariau Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.4 aut
7001 a Murphy, Rachel A.u Univ British Columbia, Vancouver, BC, Canada.4 aut
7001 a Samieri, Ceciliau Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France.4 aut
7001 a Pertiwi, Kamalitau Wageningen Univ, Div Human Nutr, Wageningen, Netherlands.4 aut
7001 a de Mello, Vanessa D.u Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.4 aut
7001 a Guan, Weihuau Univ Minnesota, Div Biostat, Minneapolis, MN USA.4 aut
7001 a Forouhi, Nita G.u Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.4 aut
7001 a Wareham, Nicku Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.4 aut
7001 a Hu, Frank B.4 aut
7001 a Risérus, Ulf,d 1967-u Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)ulfriser
7001 a Lind, Larsu Uppsala universitet,Klinisk nutrition och metabolism,Klinisk epidemiologi4 aut0 (Swepub:uu)larslind
7001 a Harris, William S.u Fatty Acid Res Inst, Sioux Falls, SD USA.;Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA.4 aut
7001 a Shadyab, Aladdin H.u Univ Calif San Diego, Sch Med, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA.4 aut
7001 a Robinson, Jennifer G.u Univ Iowa, Dept Epidemiol, Iowa City, IA USA.;Univ Iowa, Dept Med, Iowa City, IA 52242 USA.4 aut
7001 a Steffen, Lyn M.u Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.4 aut
7001 a Hodge, Allisonu Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.4 aut
7001 a Giles, Graham G.u Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia.4 aut
7001 a Ninomiya, Toshiharuu Kyushu Univ, Grad Sch Med Sci, Dept Epidemiol & Publ Hlth, Fukuoka, Japan.;Kyushu Univ, Ctr Cohort Studies, Grad Sch Med Sci, Fukuoka, Japan.4 aut
7001 a Uusitupa, Mattiu Fatty Acid Res Inst, Sioux Falls, SD USA.4 aut
7001 a Tuomilehto, Jaakkou Finnish Inst Hlth & Welf, Publ Hlth Promot Unit, Helsinki, Finland.;King Abdulaziz Univ, Diabet Res Grp, Jeddah, Saudi Arabia.4 aut
7001 a Lindstrom, Jaanau Finnish Inst Hlth & Welf, Publ Hlth Promot Unit, Helsinki, Finland.4 aut
7001 a Laakso, Markkuu Univ Eastern Finland, Inst Clin Med, Kuopio, Finland.4 aut
7001 a Siscovick, David S.u New York Acad Med, New York, NY USA.4 aut
7001 a Helmer, Catherineu Univ British Columbia, Vancouver, BC, Canada.4 aut
7001 a Geleijnse, Johanna M.u Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France.4 aut
7001 a Wu, Jason H. Y.u Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.4 aut
7001 a Fretts, Amandau Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.4 aut
7001 a Lemaitre, Rozenn N.u Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.4 aut
7001 a Micha, Renatau Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.4 aut
7001 a Mozaffarian, Dariushu Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.;Tufts Med Ctr, Div Cardiol, Boston, MA 02111 USA.4 aut
7001 a Sun, Qiu Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut
7102 a Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard Med Sch, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.b Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 org
7730 t Diabetes Cared : American Diabetes Associationg 44:5, s. 1133-1142q 44:5<1133-1142x 0149-5992x 1935-5548
8564 u https://care.diabetesjournals.org/content/diacare/44/5/1133.full.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-446186
8564 8u https://doi.org/10.2337/dc20-2426

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