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ADP-ribosyltransfer...
ADP-ribosyltransferases, an update on function and nomenclature
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- Lüscher, Bernhard (author)
- Rhein Westfal TH Aachen, Inst Biochem & Mol Biol, Aachen, Germany.
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- Ahel, Ivan (author)
- Univ Oxford, Sir William Dunn Sch Pathol, Oxford, England.
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- Altmeyer, Matthias (author)
- Univ Zurich, Dept Mol Mech Dis, Zurich, Switzerland.
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- Ashworth, Alan (author)
- UCSF Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA.
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- Bai, Peter (author)
- Univ Debrecen, Fac Med, Dept Med Chem, Debrecen, Hungary.
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- Chang, Paul (author)
- ARase Therapeut, Cambridge, MA USA.
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- Cohen, Michael (author)
- Oregon Hlth & Sci Univ, Dept Chem Physiol & Biochem, Portland, OR 97201 USA.
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- Corda, Daniela (author)
- CNR, Dept Biomed Sci, Rome, Italy.
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- Dantzer, Francoise (author)
- CNRS, BSC UMR7242, Illkirch Graffenstaden, France.
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- Daugherty, Matthew D. (author)
- Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA.
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- Dawson, Ted M. (author)
- Johns Hopkins Univ, Neuroregenerat & Stem Cell Programs, Inst Cell Engn, Sch Med, Baltimore, MD USA.
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- Dawson, Valina L. (author)
- Johns Hopkins Univ, Neuroregenerat & Stem Cell Programs, Inst Cell Engn, Sch Med, Baltimore, MD USA.
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- Deindl, Sebastian (author)
- Uppsala universitet,Molekylär systembiologi
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- Fehr, Anthony R. (author)
- Univ Kansas, Dept Mol Biosci, Lawrence, KS 66045 USA.
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- Feijs, Karla L. H. (author)
- Rhein Westfal TH Aachen, Inst Biochem & Mol Biol, Aachen, Germany.
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- Filippov, Dmitri V. (author)
- Leiden Univ, Leiden Inst Chem, Leiden, Netherlands.
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- Gagné, Jean-Philippe (author)
- Laval Univ, Dept Mol Biol Med Biochem & Pathol, Fac Med, Quebec City, PQ, Canada.
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- Grimaldi, Giovanna (author)
- CNR, Naples, Italy.
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- Guettler, Sebastian (author)
- Inst Canc Res ICR, Div Struct Biol, London, England.;Inst Canc Res ICR, Div Canc Biol, London, England.
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- Hoch, Nicolas C. (author)
- Univ Sao Paulo, Dept Biochem, Sao Paulo, Brazil.
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- Hottiger, Michael O. (author)
- Univ Zurich, Dept Mol Mech Dis, Zurich, Switzerland.
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- Korn, Patricia (author)
- Rhein Westfal TH Aachen, Inst Biochem & Mol Biol, Aachen, Germany.
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- Kraus, W. Lee (author)
- Univ Texas Southwestern Med Ctr, Cecil H & Ida Green Ctr Reprod Biol Sci, Dallas, TX USA.
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- Ladurner, Andreas (author)
- Ludwig Maximilians Univ Munchen, Dept Physiol Chem, Planegg Martinsried, Germany.
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- Lehtiö, Lari (author)
- Univ Oulu, Fac Biochem & Mol Med, Oulu, Finland.;Bioctr Oulu, Oulu, Finland.
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- Leung, Anthony K. L. (author)
- Johns Hopkins Univ, Dept Biochem & Mol Biol, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
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- Lord, Christopher J. (author)
- Inst Canc Res, Breast Canc Now Toby Robins Res Ctr, CRUK Gene Funct Lab, London, England.
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- Mangerich, Aswin (author)
- Univ Konstanz, Dept Biol, Constance, Germany.
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- Matic, Ivan (author)
- Max Planck Inst Biol Ageing, Cologne, Germany.;Univ Cologne, Cologne Excellence Cluster Stress Responses Agein, Cologne, Germany.
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- Matthews, Jason (author)
- Univ Oslo, Inst Basic Med Sci, Oslo, Norway.
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- Moldovan, George-Lucian (author)
- Penn State Univ, Dept Biochem & Mol Biol, Coll Med, Hershey, PA USA.
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- Moss, Joel (author)
- NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA.
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- Natoli, Gioacchino (author)
- European Inst Oncol IEO, Dept Expt Oncol, Milan, Italy.
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- Nielsen, Michael L. (author)
- Univ Copenhagen, Novo Nordisk Fdn, Fac Hlth & Med Sci, Prote Program,Ctr Prot Res, Copenhagen, Denmark.
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- Niepel, Mario (author)
- Ribon Therapeut, Cambridge, MA USA.
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- Nolte, Friedrich (author)
- Univ Klinikum Hamburg Eppendorf, Inst Immunol, Hamburg, Germany.
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- Pascal, John (author)
- Univ Montreal, Biochem & Mol Med, Montreal, PQ, Canada.
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- Paschal, Bryce M. (author)
- Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA USA.
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- Pawlowski, Krzysztof (author)
- Univ Texas Southwestern Med Ctr, Dept Mol Biol, Dallas, TX USA.
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- Poirier, Guy G. (author)
- Laval Univ, Dept Mol Biol Med Biochem & Pathol, Fac Med, Quebec City, PQ, Canada.
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- Smith, Susan (author)
- Univ Zurich, Dept Mol Mech Dis, Zurich, Switzerland.;NYU, Kimmel Ctr Biol & Med, Dept Pathol, Skirball Inst,Sch Med, New York, NY 10003 USA.
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- Timinszky, Gyula (author)
- Eotvos Lorand Res Network ELKH, Lendulet Lab DNA Damage & Nucl Dynam, Inst Genet, Biol Res Ctr, Szeged, Hungary.
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- Wang, Zhao-Qi (author)
- Leibniz Inst Aging, Fritz Lipmann Inst FLI, Jena, Germany.;Friedrich Schiller Univ Jena, Fac Biol Sci, Jena, Germany.
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- Yelamos, Jose (author)
- Hosp del Mar Med Res Inst IMIM, Canc Res Program, Barcelona, Spain.
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- Yu, Xiaochun (author)
- Westlake Univ, Sch Life Sci, Hangzhou, Peoples R China.
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- Zaja, Roko (author)
- Rhein Westfal TH Aachen, Inst Biochem & Mol Biol, Aachen, Germany.
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- Ziegler, Mathias (author)
- Univ Bergen, Dept Biomed, Bergen, Norway.
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Rhein Westfal TH Aachen, Inst Biochem & Mol Biol, Aachen, Germany Univ Oxford, Sir William Dunn Sch Pathol, Oxford, England. (creator_code:org_t)
- 2021-09-13
- 2022
- English.
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In: The FEBS Journal. - : John Wiley & Sons. - 1742-464X .- 1742-4658. ; 289:23, s. 7399-7410
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Abstract
Subject headings
Close
- ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for example, by DNA damage and viral infection and is involved in intra- and extracellular signaling, chromatin and transcriptional regulation, protein biosynthesis, and cell death. ADP-ribosylation is catalyzed by ADP-ribosyltransferases (ARTs), which transfer ADP-ribose from NAD+ onto substrates. The modification, which occurs as mono- or poly-ADP-ribosylation, is reversible due to the action of different ADP-ribosylhydrolases. Importantly, inhibitors of ARTs are approved or are being developed for clinical use. Moreover, ADP-ribosylhydrolases are being assessed as therapeutic targets, foremost as antiviral drugs and for oncological indications. Due to the development of novel reagents and major technological advances that allow the study of ADP-ribosylation in unprecedented detail, an increasing number of cellular processes and pathways are being identified that are regulated by ADP-ribosylation. In addition, characterization of biochemical and structural aspects of the ARTs and their catalytic activities have expanded our understanding of this protein family. This increased knowledge requires that a common nomenclature be used to describe the relevant enzymes. Therefore, in this viewpoint, we propose an updated and broadly supported nomenclature for mammalian ARTs that will facilitate future discussions when addressing the biochemistry and biology of ADP-ribosylation. This is combined with a brief description of the main functions of mammalian ARTs to illustrate the increasing diversity of mono- and poly-ADP-ribose mediated cellular processes.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- ADP-ribosylation
- MARylation
- PARP
- PARylation
- posttranslational modification
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lüscher, Bernhar ...
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Ahel, Ivan
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Altmeyer, Matthi ...
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Ashworth, Alan
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Bai, Peter
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Chang, Paul
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show more...
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Cohen, Michael
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Corda, Daniela
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Dantzer, Francoi ...
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Daugherty, Matth ...
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Dawson, Ted M.
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Dawson, Valina L ...
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Deindl, Sebastia ...
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Fehr, Anthony R.
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Feijs, Karla L. ...
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Filippov, Dmitri ...
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Gagné, Jean-Phil ...
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Grimaldi, Giovan ...
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Guettler, Sebast ...
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Hoch, Nicolas C.
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Hottiger, Michae ...
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Korn, Patricia
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Kraus, W. Lee
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Ladurner, Andrea ...
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Lehtiö, Lari
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Leung, Anthony K ...
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Lord, Christophe ...
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Mangerich, Aswin
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Matic, Ivan
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Matthews, Jason
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Moldovan, George ...
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Moss, Joel
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Natoli, Gioacchi ...
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Nielsen, Michael ...
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Niepel, Mario
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Nolte, Friedrich
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Pascal, John
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Paschal, Bryce M ...
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Pawlowski, Krzys ...
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Poirier, Guy G.
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Smith, Susan
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Timinszky, Gyula
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Wang, Zhao-Qi
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Yelamos, Jose
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Yu, Xiaochun
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Zaja, Roko
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Ziegler, Mathias
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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The FEBS Journal
- By the university
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Uppsala University