WFRF:(Kornmark Louise)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03622naa a2200397 4500 | |
| 001 | oai:DiVA.org:liu-16750 | |
| 003 | SwePub | |
| 008 | 090213s2009 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-167502 URI |
| 024 | 7 | a https://doi.org/10.1016/j.atherosclerosis.2008.03.0272 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Li, Weiu Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)weili19 |
| 245 | 1 0 | a Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis |
| 264 | 1 | b Elsevier BV,c 2009 |
| 338 | a print2 rdacarrier | |
| 520 | a Objective: Human atherosclerotic lesions overexpress elastolytic and collagenolytic cathepsins with unclear pathological implications. The aim of this study was to investigate the relationship among expression of cathepsin L. macrophage apoptosis in coronary artery disease (CAD) patients, clinical symptoms and plaque severity Of human carotid atheroma.Methods and results: Quantitative immunohistochemical analysis of human carotid atherosclerotic lesions (n = 49) showed that expression of lysosomal cathepsin L was significantly increased in atherosclerotic plaques with formation of the necrotic core and rupture of the cap. In those Plaques, cathepsin L was associated mainly with CD68-positive macrophages, whereas significant lower levels of smooth muscle cell actin were detected. The expression of cathepsin L in these plaques was also correlated with apoptosis and the stress protein ferritin. Plaques from symptomatic patients showed greater increased levels of cathepsin L than those front asymptomatic patients. Human monocyte-derived macrophages from CAD patients (n = 7) showed significantly higher levels of cathepsin L, cellular lipids and apoptosis versus cells from matched healthy donors (n = 7). 7Beta-hydroxycholesterol significantly enhanced cathepsin L in cells from healthy donors but not in Cells from CAD patients. Moreover. macrophage apoptosis was significantly correlated with expression of cathepsin L in cell nuclei and membranes.Conclusion: The results Suggest that cathepsin L is involved in death of macrophages necrotic Core formation and development of atherosclerotic plaque instability. Macrophage lysosomal cathepsin L and related apoptosis may be potential targets for modulation or imaging of vulnerable plaques in human atherosclerosis. | |
| 653 | a Atherosclerosis | |
| 653 | a Apoptosis | |
| 653 | a Cathepsin L | |
| 653 | a Lipid | |
| 653 | a Macrophage | |
| 653 | a Oxysterol | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Kornmark, Louiseu Linköpings universitet,Experimentell patologi,Hälsouniversitetet4 aut |
| 700 | 1 | a Jonasson, Lenau Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken4 aut0 (Swepub:liu)lenjo59 |
| 700 | 1 | a Forssell, Claesu Linköpings universitet,Kärlkirurgi,Hälsouniversitetet4 aut |
| 700 | 1 | a Yuan, Ximingu Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken4 aut0 (Swepub:liu)ximyu81 |
| 710 | 2 | a Linköpings universitetb Avdelningen för cellbiologi4 org |
| 773 | 0 | t Atherosclerosisd : Elsevier BVg 202:1, s. 92-102q 202:1<92-102x 0021-9150x 1879-1484 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16750 |
| 856 | 4 8 | u https://doi.org/10.1016/j.atherosclerosis.2008.03.027 |
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- Li, Wei
- Kornmark, Louise
- Jonasson, Lena
- Forssell, Claes
- Yuan, Ximing
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- Atherosclerosis
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