WFRF:(Kramm CM)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03593naa a2200793 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:151504311 | |
| 003 | SwePub | |
| 008 | 240701s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1515043112 URI |
| 024 | 7 | a https://doi.org/10.1038/s41698-022-00335-y2 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Peterziel, H4 aut |
| 245 | 1 0 | a Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM |
| 264 | c 2022-12-27 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2022 |
| 520 | a The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a library of 75–78 clinically relevant drugs. We included 132 viable tumor samples from 35 pediatric oncology centers in seven countries. DSP was conducted on multicellular fresh tumor tissue spheroid cultures in 384-well plates with an overall mean processing time of three weeks. In 89 cases (67%), sufficient viable tissue was received; 69 (78%) passed internal quality controls. The DSP results matched the identified molecular targets, including BRAF, ALK, MET, and TP53 status. Drug vulnerabilities were identified in 80% of cases lacking actionable (very) high-evidence molecular events, adding value to the molecular data. Striking parallels between clinical courses and the DSP results were observed in selected patients. Overall, DSP in clinical real-time is feasible in international multicenter precision oncology programs. | |
| 700 | 1 | a Jamaladdin, N4 aut |
| 700 | 1 | a ElHarouni, D4 aut |
| 700 | 1 | a Gerloff, XF4 aut |
| 700 | 1 | a Herter, S4 aut |
| 700 | 1 | a Fiesel, P4 aut |
| 700 | 1 | a Berker, Y4 aut |
| 700 | 1 | a Blattner-Johnson, M4 aut |
| 700 | 1 | a Schramm, K4 aut |
| 700 | 1 | a Jones, BC4 aut |
| 700 | 1 | a Reuss, D4 aut |
| 700 | 1 | a Turunen, L4 aut |
| 700 | 1 | a Friedenauer, A4 aut |
| 700 | 1 | a Holland-Letz, T4 aut |
| 700 | 1 | a Sill, M4 aut |
| 700 | 1 | a Weiser, L4 aut |
| 700 | 1 | a Previti, C4 aut |
| 700 | 1 | a Balasubramanian, G4 aut |
| 700 | 1 | a Gerber, NU4 aut |
| 700 | 1 | a Gojo, J4 aut |
| 700 | 1 | a Hutter, C4 aut |
| 700 | 1 | a Ora, I4 aut |
| 700 | 1 | a Lohi, O4 aut |
| 700 | 1 | a Kattamis, A4 aut |
| 700 | 1 | a de Wilde, B4 aut |
| 700 | 1 | a Westermann, F4 aut |
| 700 | 1 | a Tippelt, S4 aut |
| 700 | 1 | a Graf, N4 aut |
| 700 | 1 | a Nathrath, M4 aut |
| 700 | 1 | a Sparber-Sauer, M4 aut |
| 700 | 1 | a Sehested, A4 aut |
| 700 | 1 | a Kramm, CM4 aut |
| 700 | 1 | a Dirksen, U4 aut |
| 700 | 1 | a Kallioniemi, Ou Karolinska Institutet4 aut |
| 700 | 1 | a Pfister, SM4 aut |
| 700 | 1 | a van Tilburg, CM4 aut |
| 700 | 1 | a Jones, DTW4 aut |
| 700 | 1 | a Saarela, J4 aut |
| 700 | 1 | a Pietiaeinen, V4 aut |
| 700 | 1 | a Jaeger, N4 aut |
| 700 | 1 | a Schlesner, M4 aut |
| 700 | 1 | a Kopp-Schneider, A4 aut |
| 700 | 1 | a Oppermann, S4 aut |
| 700 | 1 | a Milde, T4 aut |
| 700 | 1 | a Witt, O4 aut |
| 700 | 1 | a Oehme, I4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t NPJ precision oncologyd : Springer Science and Business Media LLCg 6:1, s. 94-q 6:1<94-x 2397-768X |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:151504311 |
| 856 | 4 8 | u https://doi.org/10.1038/s41698-022-00335-y |
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- Gerber, NU
- Gojo, J
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- Westermann, F
- Tippelt, S
- Graf, N
- Nathrath, M
- Sparber-Sauer, M
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- Dirksen, U
- Kallioniemi, O
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