VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

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Fältnamn	Indikatorer	Metadata
000		06305naa a2200721 4500
001		oai:DiVA.org:uu-105750
003		SwePub
008		090608s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:118626170
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1057502 URI
024	7	a https://doi.org/10.1073/pnas.08130611062 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1186261702 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Zhang, Fanu National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA4 aut
245	1 0	a VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
264		c 2009-04-14
264	1	b Proceedings of the National Academy of Sciences,c 2009
338		a print2 rdacarrier
520		a VEGF-B, a homolog of VEGF discovered a long time ago, has not been considered an important target in antiangiogenic therapy. Instead, it has received little attention from the field. In this study, using different animal models and multiple types of vascular cells, we revealed that although VEGF-B is dispensable for blood vessel growth, it is critical for their survival. Importantly, the survival effect of VEGF-B is not only on vascular endothelial cells, but also on pericytes, smooth muscle cells, and vascular stem/progenitor cells. In vivo, VEGF-B targeting inhibited both choroidal and retinal neovascularization. Mechanistically, we found that the vascular survival effect of VEGF-B is achieved by regulating the expression of many vascular prosurvival genes via both NP-1 and VEGFR-1. Our work thus indicates that the function of VEGF-B in the vascular system is to act as a "survival," rather than an "angiogenic" factor and that VEGF-B inhibition may offer new therapeutic opportunities to treat neovascular diseases.
653		a Apoptosis
653		a vascular survival
653		a ocular neovascularization
653		a MEDICINE
653		a MEDICIN
700	1	a Tang, Zhongshuu National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA4 aut
700	1	a Hou, Xuu National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA4 aut
700	1	a Lennartsson, Johanu Uppsala universitet,Ludwiginstitutet för cancerforskning4 aut0 (Swepub:uu)johalenn
700	1	a Li, Yangu National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA4 aut
700	1	a Koch, Alexander W.u Neurodegeneration Labs, Protein Chemistry, Genentech, Inc. San Francisco, CA 94080, USA4 aut
700	1	a Scotney, Pierreu CSL Limited, Parkville, Victoria 3052, Australia4 aut
700	1	a Lee, Chunsiku National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA4 aut
700	1	a Arjunan, Pachiappanu National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA4 aut
700	1	a Dong, Lijinu National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA4 aut
700	1	a Kumar, Anilu National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA4 aut
700	1	a Rissanen, Tuomas T.u Department of Biotechnology and Molecular Medicine, University of Kuopio, FIN-70211, Kuopio, Finland4 aut
700	1	a Wang, Binu Department of Radiology, Medical Imaging Centre of the Affiliated Hospital, Weifang Medical University, Weifang 261042, China4 aut
700	1	a Nagai, Nobuou Department of Physiology, Kinki University School of Medicine, Osaka 589-8511, Japan4 aut
700	1	a Fons, Pierreu Sanofi-Aventis Recherche, Cardiovascular-Thrombosis Research Department, 31036 Toulouse Cedex, France4 aut
700	1	a Fariss, Robertu National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA4 aut
700	1	a Zhang, Yongqingu TRIAD Technology Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA4 aut
700	1	a Wawrousek, Ericu National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA4 aut
700	1	a Tansey, Gingeru National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA4 aut
700	1	a Raber, Jamesu National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA4 aut
700	1	a Fong, Guo-Huau Center for Vascular Biology, University of Connecticut, Farmington, CT 06030, USA4 aut
700	1	a Ding, Haou Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada MB R3E 3P54 aut
700	1	a Greenberg, David A.u Buck Institute for Age Research, Novato, CA 94945, USA4 aut
700	1	a Becker, Kevin G.u TRIAD Technology Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA4 aut
700	1	a Herbert, Jean-Marcu Sanofi-Aventis Recherche, Cardiovascular-Thrombosis Research Department, 31036 Toulouse Cedex, France4 aut
700	1	a Nash, Andrewu CSL Limited, Parkville, Victoria 3052, Australia4 aut
700	1	a Yla-Herttuala, Seppou Department of Biotechnology and Molecular Medicine, University of Kuopio, FIN-70211, Kuopio, Finland4 aut
700	1	a Cao, Yihaiu Karolinska Institutet4 aut
700	1	a Watts, Ryan J.u Neurodegeneration Labs, Protein Chemistry, Genentech, Inc. San Francisco, CA 94080; dCSL Limited, Parkville, Victoria 3052, Australia4 aut
700	1	a Li, Xuriu National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA4 aut
710	2	a National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USAb Ludwiginstitutet för cancerforskning4 org
773	0	t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 106:15, s. 6152-6157q 106:15<6152-6157x 0027-8424x 1091-6490
856	4	u https://www.pnas.org/content/pnas/106/15/6152.full.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105750
856	4 8	u https://doi.org/10.1073/pnas.0813061106
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:118626170

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