Sökning: WFRF:(Laitinen Kirsi) > (2020-2024) > Loading enhances gl...
Fältnamn | Indikatorer | Metadata |
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000 | 03742naa a2200409 4500 | |
001 | oai:gup.ub.gu.se/337893 | |
003 | SwePub | |
008 | 240717s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3378932 URI |
024 | 7 | a https://doi.org/10.1210/clinem/dgae3442 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bellman, Jakob4 aut |
245 | 1 0 | a Loading enhances glucose uptake in muscles, bones, and bone marrow of lower extremities in humans. |
264 | 1 | c 2024 |
520 | a Increased standing time has been associated with improved health, but the underlying mechanism is unclear.We herein investigate if increased weight loading increases energy demand and thereby glucose uptake (GU) locally in bone and/or muscle in the lower extremities.In this single-center clinical trial with randomized crossover design (ClinicalTrials.gov ID, NCT05443620), we enrolled 10 men with body mass index (BMI) between 30 and 35kg/m2. Participants were treated with both high load (standing with weight vest weighing 11% of body weight) and no load (sitting) on the lower extremities. GU was measured using whole-body quantitative positron emission tomography/computed tomography (PET/CT) imaging. The primary endpoint was the change in GU ratio between loaded bones (i.e. femur and tibia) and non-loaded bones (i.e. humerus).High load increased the GU ratio between lower and upper extremities in cortical diaphyseal bone (e.g. femur/humerus ratio increased by 19%, p=0.029), muscles (e.g. m. quadriceps femoris/m. triceps brachii ratio increased by 28%, p=0.014) and in certain bone marrow regions (femur/humerus diaphyseal bone marrow region ratio increased by 17%, p=0.041). Unexpectedly, we observed the highest GU in the bone marrow region of vertebral bodies, but its GU was not affected by high load.Increased weight-bearing loading enhances GU in muscles, cortical bone, and bone marrow of the exposed lower extremities. This could be interpreted as increased local energy demand in bone and muscle caused by increased loading. The physiological importance of the increased local GU by static loading remains to be determined. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Sjöros, Tanja4 aut |
700 | 1 | a Hägg, Daniel,d 1974u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xhagda |
700 | 1 | a Atencio Herre, Erika4 aut |
700 | 1 | a Hieta, Janina4 aut |
700 | 1 | a Eskola, Olli4 aut |
700 | 1 | a Laitinen, Kirsi4 aut |
700 | 1 | a Nuutila, Pirjo4 aut |
700 | 1 | a Jansson, John-Olov4 aut |
700 | 1 | a Jansson, Per-Anders4 aut |
700 | 1 | a Kalliokoski, Kari4 aut |
700 | 1 | a Roivainen, Anne4 aut |
700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl |
710 | 2 | a Göteborgs universitetb Centre for Bone and Arthritis Research4 org |
773 | 0 | t The Journal of clinical endocrinology and metabolismx 1945-7197 |
856 | 4 8 | u https://gup.ub.gu.se/publication/337893 |
856 | 4 8 | u https://doi.org/10.1210/clinem/dgae344 |
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