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Sökning: WFRF:(Lanner Ulrike) > (2021) > Quorum sensing gove...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004017naa a2200493 4500
001oai:DiVA.org:liu-178449
003SwePub
008210824s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1784492 URI
0247 a https://doi.org/10.15252/embr.2021529722 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Striednig, Biancau Univ Zurich, Switzerland4 aut
2451 0a Quorum sensing governs a transmissive Legionella subpopulation at the pathogen vacuole periphery
264 c 2021-07-27
264 1b Wiley-Blackwell,c 2021
338 a electronic2 rdacarrier
500 a Funding Agencies|Swiss National Science Foundation (SNF)Swiss National Science Foundation (SNSF) [31003A_175557, 310030_200706]; SNF Ambizione fellowship [PZ00P3_161492, PZ00P3_185529]
520 a The Gram-negative bacterium Legionella pneumophila is the causative agent of Legionnaires disease and replicates in amoebae and macrophages within a distinct compartment, the Legionella-containing vacuole (LCV). The facultative intracellular pathogen switches between a replicative, non-virulent and a non-replicating, virulent/transmissive phase. Here, we show on a single-cell level that at late stages of infection, individual motile (P-flaA-GFP-positive) and virulent (P-ralF- and P-sidC-GFP-positive) L. pneumophila emerge in the cluster of non-growing bacteria within an LCV. Comparative proteomics of P-flaA-GFP-positive and P-flaA-GFP-negative L. pneumophila subpopulations reveals distinct proteomes with flagellar proteins or cell division proteins being preferentially produced by the former or the latter, respectively. Toward the end of an infection cycle (similar to 48 h), the P-flaA-GFP-positive L. pneumophila subpopulation emerges at the cluster periphery, predominantly escapes the LCV, and spreads from the bursting host cell. These processes are mediated by the Legionella quorum sensing (Lqs) system. Thus, quorum sensing regulates the emergence of a subpopulation of transmissive L. pneumophila at the LCV periphery, and phenotypic heterogeneity underlies the intravacuolar bi-phasic life cycle of L. pneumophila.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
653 a flagellum; pathogen vacuole; phenotypic heterogeneity; proteome; quorum sensing
7001 a Lanner, Ulrikeu Univ Basel, Switzerland4 aut
7001 a Niggli, Selinau Univ Zurich, Switzerland; Univ Zurich, Switzerland4 aut
7001 a Katic, Anau Univ Zurich, Switzerland4 aut
7001 a Vormittag, Simoneu Univ Zurich, Switzerland4 aut
7001 a Brülisauer, Sabrinau Univ Zurich, Switzerland4 aut
7001 a Hochstrasser, Ramonu Univ Zurich, Switzerland4 aut
7001 a Kaech, Andresu Univ Zurich, Switzerland4 aut
7001 a Welin, Amandau Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten4 aut0 (Swepub:liu)amawe34
7001 a Flieger, Antjeu Robert Koch Inst, Germany4 aut
7001 a Ziegler, Ursu Univ Zurich, Switzerland4 aut
7001 a Schmidt, Alexanderu Univ Basel, Switzerland4 aut
7001 a Hilbi, Hubertu Univ Zurich, Switzerland4 aut
7001 a Personnic, Nicolasu Univ Zurich, Switzerland4 aut
7102 a Univ Zurich, Switzerlandb Univ Basel, Switzerland4 org
7730 t EMBO Reportsd : Wiley-Blackwellg 22:9q 22:9x 1469-221Xx 1469-3178
8564 u https://liu.diva-portal.org/smash/get/diva2:1587357/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embr.202152972
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-178449
8564 8u https://doi.org/10.15252/embr.202152972

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