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Plasma lipidome and...
Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial
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- Toledo, Estefania (author)
- Universidad de Navarra,University of Navarra
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- Wittenbecher, Clemens, 1981 (author)
- Harvard School of Public Health, United States,Chalmers tekniska högskola,Chalmers University of Technology
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- Razquin, Cristina (author)
- Universidad de Navarra,University of Navarra
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- Ruiz-Canela, Miguel (author)
- Universidad de Navarra,University of Navarra
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- Clish, Clary B. (author)
- Broad Institute
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- Liang, Liming (author)
- Harvard School of Public Health, United States,Harvard School of Public Health, United States
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Alonso, Alvaro (author)
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Hernández-Alonso, Pablo (author)
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- Becerra-Tomás, Nerea (author)
- Universitat de Valencia
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Arós-Borau, Fernando (author)
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- Corella, Dolores (author)
- Universitat de Valencia
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Ros, Emilio (author)
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- Estruch, Ramon (author)
- Universitat de Barcelona,University of Barcelona
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- García-Rodríguez, Antonio (author)
- Universidad De Malaga,University of Malaga
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Fitó, Montse (author)
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Lapetra, José (author)
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Fiol, Miquel (author)
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Alonso-Gómez, Angel (author)
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Serra-Majem, Luis (author)
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- Deik, Amy (author)
- Broad Institute
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Salas-Salvadó, Jordi (author)
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- Hu, Frank B. (author)
- Harvard School of Public Health, United States,Brigham and Women's Hospital
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- Martínez-González, Miguel A. (author)
- Harvard School of Public Health, United States,Universidad de Navarra,University of Navarra
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Journal of Physiology and Biochemistry. - 1138-7548 .- 1877-8755. ; 79:2, s. 355-364
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Abstract
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- The potential role of the lipidome in atrial fibrillation (AF) development is still widely unknown. We aimed to assess the association between lipidome profiles of the Prevención con Dieta Mediterránea (PREDIMED) trial participants and incidence of AF. We conducted a nested case–control study (512 incident centrally adjudicated AF cases and 735 controls matched by age, sex, and center). Baseline plasma lipids were profiled using a Nexera X2 U-HPLC system coupled to an Exactive Plus orbitrap mass spectrometer. We estimated the association between 216 individual lipids and AF using multivariable conditional logistic regression and adjusted the p values for multiple testing. We also examined the joint association of lipid clusters with AF incidence. Hitherto, we estimated the lipidomics network, used machine learning to select important network-clusters and AF-predictive lipid patterns, and summarized the joint association of these lipid patterns weighted scores. Finally, we addressed the possible interaction by the randomized dietary intervention. Forty-one individual lipids were associated with AF at the nominal level (p < 0.05), but no longer after adjustment for multiple-testing. However, the network-based score identified with a robust data-driven lipid network showed a multivariable-adjusted ORper+1SD of 1.32 (95% confidence interval: 1.16–1.51; p < 0.001). The score included PC plasmalogens and PE plasmalogens, palmitoyl-EA, cholesterol, CE 16:0, PC 36:4;O, and TG 53:3. No interaction with the dietary intervention was found. A multilipid score, primarily made up of plasmalogens, was associated with an increased risk of AF. Future studies are needed to get further insights into the lipidome role on AF. Current Controlled Trials number, ISRCTN35739639.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Metabolomics
- Atrial fibrillation
- Dietary intervention
- Lipidomics
- Nested case–control study
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Toledo, Estefani ...
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Wittenbecher, Cl ...
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Razquin, Cristin ...
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Ruiz-Canela, Mig ...
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Clish, Clary B.
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Liang, Liming
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show more...
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Alonso, Alvaro
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Hernández-Alonso ...
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Becerra-Tomás, N ...
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Arós-Borau, Fern ...
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Corella, Dolores
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Ros, Emilio
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Estruch, Ramon
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García-Rodríguez ...
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Fitó, Montse
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Lapetra, José
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Fiol, Miquel
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Alonso-Gómez, An ...
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Serra-Majem, Lui ...
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Deik, Amy
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Salas-Salvadó, J ...
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Hu, Frank B.
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Martínez-Gonzále ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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Journal of Physi ...
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Chalmers University of Technology