The brain is a source of S100B increase during endotoxemia in the pig

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Larsson Matts) > (2010-2014) > The brain is a sour...

1 of 16
Previous record
Next record
To hitlist

The brain is a source of S100B increase during endotoxemia in the pig

Lipcsey, Miklos (author): Uppsala universitet,Anestesiologi och intensivvård

Olovsson, Matts (author): Uppsala universitet,Obstetrik & gynekologi,Klinisk och experimentell reproduktionsbiologi/Olovsson

Larsson, Erik (author): Uppsala universitet,Institutionen för genetik och patologi

Einarsson, Roland (author)

Abdul Qadhr, Goran (author): Uppsala universitet,Enheten för radiologi

Sjölin, Jan (author): Uppsala universitet,Infektionssjukdomar

Larsson, Anders (author): Uppsala universitet,Klinisk kemi

show less...

(creator_code:org_t)

2010
2010
English.
In: Anesthesia and Analgesia. - 0003-2999 .- 1526-7598. ; 110:1, s. 174-180

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

BACKGROUND:Cerebral dysfunction frequently complicates septic shock. A marker of cerebral dysfunction could be of significant value in managing sedated septic patients. Plasma S100 (S100B) proteins increase in sepsis. S100B is present not only in the brain but also in other tissues. The source of this protein has not been investigated in sepsis. Our aim in this study was to determine whether the brain is an important source of S100B in an experimental sepsis model.METHODS:Twenty-seven pigs were anesthetized and randomized to either infusion of endotoxin at the rate of 1 µg · kg-1 · h-1 (n = 19) or saline (n = 8). Catheters were inserted into a cervical artery and the superior sagittal sinus. Blood samples were collected from both sites and physiologic data were registered before the start of the endotoxin infusion and hourly during the experiment. After 6 h, the animals were killed and brain tissue samples were taken from the left hemisphere. S100B in plasma was measured by enzyme-linked immunosorbent assay. Brain tissue samples were stained with biotinylated S100B antibodies.RESULTS: In the endotoxemic animals, the arterial S100B concentration increased to 442 ± 33 and 421 ± 24 ng/L at 1 and 2 h, respectively, vs 306 ± 28 and 261 ± 25 ng/L in controls (P = 0.018 and 0.00053, respectively). Mean superior sagittal sinus S100B concentrations were higher than mean arterial concentrations at all time points in the endotoxemic animals; however, significance was only reached at 2 h (P = 0.033). The focal glial S100B expression was more intense in the endotoxemic pigs than in controls (P = 0.0047).CONCLUSIONS:Our results support the hypothesis that the brain is an important source of S100B in endotoxemia even though there may be other sources. These findings make S100B a candidate as a marker of cerebral dysfunction in septic shock.

Keyword

MEDICINE
MEDICIN

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

Anesthesia and Analgesia (Search for host publication in LIBRIS)

To the university's database

1 of 16
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Lipcsey, Miklos; Olovsson, Matts; Larsson, Erik; Einarsson, Rolan ...; Abdul Qadhr, Gor ...; Sjölin, Jan; show more...; Larsson, Anders; show less...

Articles in the publication: Anesthesia and A ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se