WFRF:(Larsson Rolf)
Sökning: WFRF:(Larsson Rolf) > (2005-2009) > Effects on blood co...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03655naa a2200385 4500 | |
| 001 | oai:DiVA.org:uu-95970 | |
| 003 | SwePub | |
| 008 | 070525s2006 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-959702 URI |
| 024 | 7 | a https://doi.org/10.1080/095371006007465572 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Christensen, Kjeldu Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi4 aut |
| 245 | 1 0 | a Effects on blood compatibility in vitro by combining a direct P2Y(12) receptor inhibitor and heparin coating of stents |
| 264 | c 2009-07-07 | |
| 264 | 1 | b Informa UK Limited,c 2006 |
| 338 | a print2 rdacarrier | |
| 520 | a The effect of the direct platelet P2Y12 receptor inhibitor, AR-C69931MX, on activation of blood induced by stents with and without heparin coating was investigated using a whole blood Chandler loop model in vitro . Stents were deployed in Chandler loops. Fresh human blood with heparin and AR-C69931MX was rotated for 1 h at 37°C and used for measurements of platelets, microparticles, thrombin-antithrombin complex (TAT), fibrinogen binding to platelets, P-selectin expression by platelets, CD11b, Prothrombin Fragment F1+2, FXIa-AT, FXIIa-AT, C3a, sC5b-9 and stent score. In the first experiment there were four study groups with unmodified stents: 1a, no AR-C69931MX; 1b, 250 nmol/L; 1c, 750 nmol/L; 1d, 2250 nmol/L of AR-C69931MX. In the second experiment the concentration of AR-C69931MX was 500 nmol/L: 2a; tubings without stent; 2b; tubings with heparin-coated stent; 2c; tubings with unmodified stents. Heparin-coated stents were used in the third experiment: 3a; no AR-C69931MX; 3b; 500 nmol/L of AR-C69931MX. In the first experiment there were significant differences in all parameters analysed except for C3a, and stent score when the group with no AR-C69931MX was compared to all the groups with AR-C69931MX. In the second experiment there were significant differences in platelet count, TAT, FXIa-AT, FXIIa-AT and stent score when unmodified stents were compared to loops with no stents and partly to loops with heparin-coated stents. In the third experiment there was a significant reduction in generation of TAT, stent score and better preservation of platelet number by combining the platelet inhibitor and heparin-coated stents as compared to heparin-coated stents alone. The conclusion is that the direct P2Y12 receptor inhibitor AR-C69931MX reduced the different aspects of activation of blood induced by both unmodified and heparin-coated stents. | |
| 653 | a Heparin coating | |
| 653 | a Platelets | |
| 653 | a Purin receptor blockade | |
| 653 | a Stents | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Larsson, Rolfu Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi4 aut0 (Swepub:uu)rolflars |
| 700 | 1 | a Emanuelsson, Håkan4 aut |
| 700 | 1 | a Elgue, Gracielau Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi4 aut0 (Swepub:uu)gracelgu |
| 700 | 1 | a Larsson, Andersu Uppsala universitet,Institutionen för medicinska vetenskaper,Biokemisk struktur och funktion4 aut0 (Swepub:uu)andlarss |
| 710 | 2 | a Uppsala universitetb Institutionen för onkologi, radiologi och klinisk immunologi4 org |
| 773 | 0 | t Plateletsd : Informa UK Limitedg 17:5, s. 318-327q 17:5<318-327x 0953-7104x 1369-1635 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-95970 |
| 856 | 4 8 | u https://doi.org/10.1080/09537100600746557 |
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