WFRF:(Lazarevic V)
Sökning: WFRF:(Lazarevic V) > (2010-2014) > Microbiome of prebi...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04781naa a2200697 4500 | |
| 001 | oai:gup.ub.gu.se/205506 | |
| 003 | SwePub | |
| 008 | 240528s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2055062 URI |
| 024 | 7 | a https://doi.org/10.1038/ismej.2014.452 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Everard, A.4 aut |
| 245 | 1 0 | a Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity |
| 264 | c 2014-04-03 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2014 |
| 520 | a The gut microbiota is involved in metabolic and immune disorders associated with obesity and type 2 diabetes. We previously demonstrated that prebiotic treatment may significantly improve host health by modulating bacterial species related to the improvement of gut endocrine, barrier and immune functions. An analysis of the gut metagenome is needed to determine which bacterial functions and taxa are responsible for beneficial microbiota-host interactions upon nutritional intervention. We subjected mice to prebiotic (Pre) treatment under physiological (control diet: CT) and pathological conditions (high-fat diet: HFD) for 8 weeks and investigated the production of intestinal antimicrobial peptides and the gut microbiome. HFD feeding significantly decreased the expression of regenerating islet-derived 3-gamma (Reg3g) and phospholipase A2 group-II (PLA2g2) in the jejunum. Prebiotic treatment increased Reg3g expression (by similar to 50-fold) and improved intestinal homeostasis as suggested by the increase in the expression of intectin, a key protein involved in intestinal epithelial cell turnover. Deep metagenomic sequencing analysis revealed that HFD and prebiotic treatment significantly affected the gut microbiome at different taxonomic levels. Functional analyses based on the occurrence of clusters of orthologous groups (COGs) of proteins also revealed distinct profiles for the HFD, Pre, HFD-Pre and CT groups. Finally, the gut microbiota modulations induced by prebiotics counteracted HFD-induced inflammation and related metabolic disorders. Thus, we identified novel putative taxa and metabolic functions that may contribute to the development of or protection against the metabolic alterations observed during HFD feeding and HFD-Pre feeding. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a metagenomic | |
| 653 | a gut microbiota | |
| 653 | a type 2 diabetes | |
| 653 | a antimicrobial peptides | |
| 653 | a Reg3g | |
| 653 | a prebiotics | |
| 653 | a LIPOPOLYSACCHARIDE-BINDING PROTEIN | |
| 653 | a DIET-INDUCED OBESITY | |
| 653 | a GUT | |
| 653 | a MICROBIOTA | |
| 653 | a INSULIN-RESISTANCE | |
| 653 | a INTESTINAL EPITHELIUM | |
| 653 | a INFLAMMATION | |
| 653 | a HOMEOSTASIS | |
| 653 | a DISEASE | |
| 653 | a ENDOTOXEMIA | |
| 653 | a METABOLISM | |
| 653 | a Ecology | |
| 653 | a Microbiology | |
| 653 | a ATES OF AMERICA | |
| 653 | a V110 | |
| 653 | a P9066 | |
| 653 | a ATES OF AMERICA | |
| 653 | a V109 | |
| 653 | a P594 | |
| 700 | 1 | a Lazarevic, V.4 aut |
| 700 | 1 | a Gaia, N.4 aut |
| 700 | 1 | a Johansson, Mariau Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut |
| 700 | 1 | a Ståhlman, Marcus,d 1975u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xstahm |
| 700 | 1 | a Bäckhed, Fredrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory4 aut0 (Swepub:gu)xbafre |
| 700 | 1 | a Delzenne, N. M.4 aut |
| 700 | 1 | a Schrenzel, J.4 aut |
| 700 | 1 | a Francois, P.4 aut |
| 700 | 1 | a Cani, P. D.4 aut |
| 710 | 2 | a Göteborgs universitetb Wallenberglaboratoriet4 org |
| 773 | 0 | t Isme Journald : Springer Science and Business Media LLCg 8:10, s. 2116-2130q 8:10<2116-2130x 1751-7362x 1751-7370 |
| 856 | 4 | u https://www.nature.com/articles/ismej201445.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/205506 |
| 856 | 4 8 | u https://doi.org/10.1038/ismej.2014.45 |
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