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The histone chapero...
The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence
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Jenull, Sabrina (author)
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Mair, Theresia (author)
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Tscherner, Michael (author)
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Penninger, Philipp (author)
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Zwolanek, Florian (author)
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- Silao, Fitz-Gerald S. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Martinez de San Vicente, Kontxi (author)
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Riedelberger, Michael (author)
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Bandari, Naga C. (author)
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Shivarathri, Raju (author)
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Petryshyn, Andriy (author)
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Chauhan, Neeraj (author)
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Zacchi, Lucia F. (author)
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Leibundgut Landmann, Salomé (author)
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- Ljungdahl, Per O. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Kuchler, Karl (author)
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 36:3
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https://doi.org/10.1...
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Abstract
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- Adaptation to changing environments and immune evasion is pivotal for fitness of pathogens. Yet, the underlying mechanisms remain largely unknown. Adaptation is governed by dynamic transcriptional re-programming, which is tightly connected to chromatin architecture. Here, we report a pivotal role for the HIR histone chaperone complex in modulating virulence of the human fungal pathogen Candida albicans. Genetic ablation of HIR function alters chromatin accessibility linked to aberrant transcriptional responses to protein as nitrogen source. This accelerates metabolic adaptation and increases the release of extracellular proteases, which enables scavenging of alternative nitrogen sources. Furthermore, HIR controls fungal virulence, as HIR1 deletion leads to differential recognition by immune cells and hypervirulence in a mouse model of systemic infection. This work provides mechanistic insights into chromatin-coupled regulatory mechanisms that fine-tune pathogen gene expression and virulence. Furthermore, the data point toward the requirement of refined screening approaches to exploit chromatin modifications as antifungal strategies.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jenull, Sabrina
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Mair, Theresia
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Tscherner, Micha ...
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Penninger, Phili ...
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Zwolanek, Floria ...
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Silao, Fitz-Gera ...
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show more...
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Martinez de San ...
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Riedelberger, Mi ...
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Bandari, Naga C.
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Shivarathri, Raj ...
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Petryshyn, Andri ...
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Chauhan, Neeraj
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Zacchi, Lucia F.
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Leibundgut Landm ...
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Ljungdahl, Per O ...
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Kuchler, Karl
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Cell Reports
- By the university
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Stockholm University