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Sökning: WFRF:(Lemnge Martha) > (2012) > Biomarkers of Plasm...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003736naa a2200469 4500
001oai:DiVA.org:su-86295
003SwePub
008130111s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-862952 URI
0247 a https://doi.org/10.1371/journal.pone.00487632 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Boström, Stéphanie,d 1985-u Stockholms universitet,Wenner-Grens institut4 aut0 (Swepub:su)stbo7601
2451 0a Biomarkers of Plasmodium falciparum infection during pregnancy in women living in Northeastern Tanzania
264 c 2012-11-14
264 1b Public Library of Science (PLoS),c 2012
338 a print2 rdacarrier
520 a In pregnant women, Plasmodium falciparum infections are an important cause of maternal morbidity as well as fetal and neonatal mortality. Erythrocytes infected by these malaria-causing parasites accumulate through adhesive interactions in placental intervillous spaces, thus evading detection in peripheral blood smears. Sequestered infected erythrocytes induce inflammation, offering the possibility of detecting inflammatory mediators in peripheral blood that could act as biomarkers of placental infection. In a longitudinal, prospective study in Tanzania, we quantified a range of different cytokines, chemokines and angiogenic factors in peripheral plasma samples, taken on multiple sequential occasions during pregnancy up to and including delivery, from P. falciparum-infected women and matched uninfected controls. The results show that during healthy, uninfected pregnancies the levels of most of the panel of molecules we measured were largely unchanged except at delivery. In women with P. falciparum, however, both comparative and longitudinal assessments consistently showed that the levels of IL-10 and IP-10 increased significantly whilst that of RANTES decreased significantly, regardless of gestational age at the time the infection was detected. ROC curve analysis indicated that a combination of increased IL-10 and IP-10 levels and decreased RANTES levels might be predictive of P. falciparum infections. In conclusion, our data suggest that host biomarkers in peripheral blood may represent useful diagnostic markers of P. falciparum infection during pregnancy, but placental histology results would need to be included to verify these findings.
650 7a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng
653 a immunologi
653 a Immunology
7001 a Ibitokou, Samad4 aut
7001 a Oesterholt, Mayke4 aut
7001 a Schmiegelow, Christentze4 aut
7001 a Persson, Jan-Olovu Stockholms universitet,Matematiska institutionen4 aut0 (Swepub:su)japer
7001 a Minja, Daniel4 aut
7001 a Lusingu, John4 aut
7001 a Lemnge, Martha4 aut
7001 a Fievet, Nadine4 aut
7001 a Deloron, Philippe4 aut
7001 a Luty, Adrian J. F.4 aut
7001 a Troye-Blomberg, Maritau Stockholms universitet,Wenner-Grens institut4 aut0 (Swepub:su)marita
7102 a Stockholms universitetb Wenner-Grens institut4 org
7730 t PLOS ONEd : Public Library of Science (PLoS)g 7:11, s. e48763-q 7:11<e48763-x 1932-6203
8564 u https://doi.org/10.1371/journal.pone.0048763y Fulltext
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048763&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-86295
8564 8u https://doi.org/10.1371/journal.pone.0048763

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