Effects on neonatal exposure to the flame retardant tetrabrombisphenol-A, aluminum diethylphosphinate or zinc stannate on long-term, potentiation and synaptic protein levels in mice

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Hendriks, Hester S.Utrecht University, Utrecht, Netherlands. (author)

Effects on neonatal exposure to the flame retardant tetrabrombisphenol-A, aluminum diethylphosphinate or zinc stannate on long-term, potentiation and synaptic protein levels in mice

Article/chapterEnglish2015

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2014-09-25
Springer Nature,2015
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LIBRIS-ID:oai:DiVA.org:uu-240598
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-240598URI
https://doi.org/10.1007/s00204-014-1366-8DOI

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Language:English
Summary in:English

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De två första författarna har bidragit i lika hög grad
Brominated flame retardants such as tetrabromobisphenol-A (TBBPA) may exert (developmental) neurotoxic effects. However, data on (neuro)toxicity of halogen-free flame retardants (HFFRs) are scarce. Recent in vitro studies indicated a high neurotoxic potential for some HFFRs, e.g., zinc stannate (ZS), whereas the neurotoxic potential of other HFFRs, such as aluminum diethylphosphinate (Alpi), appears low. However, the in vivo (neuro)toxicity of these compounds is largely unknown. We therefore investigated effects of neonatal exposure to TBBPA, Alpi or ZS on synaptic plasticity in mouse hippocampus. Male C57bl/6 mice received a single oral dose of 211 µmol/kg bw TBBPA, Alpi or ZS on postnatal day (PND) 10. On PND 17–19, effects on hippocampal synaptic plasticity were investigated using ex vivo extracellular field recordings. Additionally, we measured levels of postsynaptic proteins involved in long-term potentiation (LTP) as well as flame retardant concentrations in brain, muscle and liver tissues. All three flame retardants induced minor, but insignificant, effects on LTP. Additionally, TBBPA induced a minor decrease in post-tetanic potentiation. Despite these minor effects, expression of selected synaptic proteins involved in LTP was not affected. The flame retardants could not be measured in significant amounts in the brains, suggesting low bioavailability and/or rapid elimination/metabolism. We therefore conclude that a single neonatal exposure on PND 10 to TBBPA, Alpi or ZS does affect neurodevelopment and synaptic plasticity only to a small extent in mice. Additional data, in particular on persistence, bioaccumulation and (in vivo) toxicity, following prolonged (developmental) exposure are required for further (human) risk assessment.

Subject headings and genre

NATURVETENSKAP Geovetenskap och miljövetenskap Miljövetenskap hsv//swe
NATURAL SCIENCES Earth and Related Environmental Sciences Environmental Sciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
Flame retardants; Developmental neurotoxicity; Hippocampal synaptic plasticity; Tetrabromobisphenol-A (TBBPA); Aluminum diethylphosphinate (Alpi); Zinc stannate (ZS)
Biology with specialization in Environmental Toxicology
Biologi med inriktning mot miljötoxikologi

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Koolen, Lucas A. E.Utrecht University, Utrecht, Netherlands. (author)
Dingemans, Milou M. L.Utrecht University, Utrecht, Netherlands. (author)
Viberg, HenrikUppsala universitet,Miljötoxikologi(Swepub:uu)henrvibe (author)
Lee, IwaUppsala universitet,Miljötoxikologi(Swepub:uu)iwaiw246 (author)
Leonards, Pim E.G.VU University, Amsterdam, Netherlands. (author)
Ramakers, Geert M.J.University Medical Center Utrecht, Utrecht, Netherlands. (author)
Westerink, Remco H.S.Utrecht University, Utrecht, Netherlands. (author)
Utrecht University, Utrecht, Netherlands.Miljötoxikologi (creator_code:org_t)

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In:Archives of Toxicology: Springer Nature89:12, s. 2345-23540340-57611432-0738

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