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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 21895naa a2201417 4500 | |
| 001 | oai:DiVA.org:umu-218042 | |
| 003 | SwePub | |
| 008 | 231214s2024 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2180422 URI |
| 024 | 7 | a https://doi.org/10.1038/s41416-023-02489-32 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Watts, Eleanor L.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States4 aut |
| 245 | 1 0 | a Observational and genetic associations between cardiorespiratory fitness and cancer :b a UK Biobank and international consortia study |
| 264 | 1 | b Springer Nature,c 2024 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Background: The association of fitness with cancer risk is not clear.Methods: We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of lung, colorectal, endometrial, breast, and prostate cancer in a subset of UK Biobank participants who completed a submaximal fitness test in 2009-12 (N = 72,572). We also investigated relationships using two-sample Mendelian randomisation (MR), odds ratios (ORs) were estimated using the inverse-variance weighted method.Results: After a median of 11 years of follow-up, 4290 cancers of interest were diagnosed. A 3.5 ml O2⋅min−1⋅kg−1 total-body mass increase in fitness (equivalent to 1 metabolic equivalent of task (MET), approximately 0.5 standard deviation (SD)) was associated with lower risks of endometrial (HR = 0.81, 95% CI: 0.73–0.89), colorectal (0.94, 0.90–0.99), and breast cancer (0.96, 0.92–0.99). In MR analyses, a 0.5 SD increase in genetically predicted O2⋅min−1⋅kg−1 fat-free mass was associated with a lower risk of breast cancer (OR = 0.92, 95% CI: 0.86–0.98). After adjusting for adiposity, both the observational and genetic associations were attenuated.Discussion: Higher fitness levels may reduce risks of endometrial, colorectal, and breast cancer, though relationships with adiposity are complex and may mediate these relationships. Increasing fitness, including via changes in body composition, may be an effective strategy for cancer prevention. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Gonzales, Tomas I.u MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom4 aut |
| 700 | 1 | a Strain, Tessau MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom4 aut |
| 700 | 1 | a Saint-Maurice, Pedro F.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States4 aut |
| 700 | 1 | a Bishop, D. Timothyu Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom4 aut |
| 700 | 1 | a Chanock, Stephen J.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States4 aut |
| 700 | 1 | a Johansson, Mattiasu Genomics Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France4 aut |
| 700 | 1 | a Keku, Temitope O.u Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States4 aut |
| 700 | 1 | a Le Marchand, Loicu University of Hawaii Cancer Center, HI, Honolulu, United States4 aut |
| 700 | 1 | a Moreno, Victoru Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine and University of Barcelona Institute for Complex Systems (UBICS), University of Barcelona, Barcelona, Spain; ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain4 aut |
| 700 | 1 | a Newcomb, Polly A.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States4 aut |
| 700 | 1 | a Newton, Christina C.u Department of Population Science, American Cancer Society, GA, Atlanta, United States4 aut |
| 700 | 1 | a Pai, Rish K.u Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States4 aut |
| 700 | 1 | a Purdue, Mark P.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States4 aut |
| 700 | 1 | a Ulrich, Cornelia M.u Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut |
| 700 | 1 | a Smith-Byrne, Karlu Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut |
| 700 | 1 | a van Guelpen, Bethanyu Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi4 aut0 (Swepub:umu)beyvan99 |
| 700 | 1 | a Eeles, Rosalind A.u The Institute of Cancer Research, London, United Kingdom; Royal Marsden NHS Foundation Trust, London, United Kingdom4 aut |
| 700 | 1 | a Haiman, Christopher A.u Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Kote-Jarai, Zsofiau The Institute of Cancer Research, London, United Kingdom4 aut |
| 700 | 1 | a Schumacher, Fredrick R.u Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States; Seidman Cancer Center, University Hospitals, OH, Cleveland, United States4 aut |
| 700 | 1 | a Benlloch, Sarau The Institute of Cancer Research, London, United Kingdom; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom4 aut |
| 700 | 1 | a Olama, Ali Amin Alu Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom; University of Cambridge, Department of Clinical Neurosciences, Stroke Research Group, R3, Box 83, Cambridge Biomedical Campus, Cambridge, United Kingdom4 aut |
| 700 | 1 | a Muir, Kenneth R.u Division of Population Health, Health Services Research and Primary Care, University of Manchester, Oxford Road, Manchester, United Kingdom4 aut |
| 700 | 1 | a Berndt, Sonja I.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MD, Bethesda, United States4 aut |
| 700 | 1 | a Conti, David V.u Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Wiklund, Fredriku Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden4 aut |
| 700 | 1 | a Chanock, Stephen J.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MD, Bethesda, United States4 aut |
| 700 | 1 | a Wang, Yingu Department of Population Science, American Cancer Society, 250 Williams Street, GA, Atlanta, United States4 aut |
| 700 | 1 | a Tangen, Catherine M.u SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
| 700 | 1 | a Batra, Jyotsnau Translational Research Institute, QLD, Brisbane, Australia; Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, QLD, Brisbane, Australia4 aut |
| 700 | 1 | a Clements, Judith A.u Translational Research Institute, QLD, Brisbane, Australia; Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, QLD, Brisbane, Australia4 aut |
| 700 | 1 | a Grönberg, Henriku Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MD, Bethesda, United States4 aut |
| 700 | 1 | a Pashayan, Norau Department of Applied Health Research, University College London, London, United Kingdom; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, United Kingdom4 aut |
| 700 | 1 | a Schleutker, Johannau Institute of Biomedicine, University of Turku, Turku, Finland; Department of Medical Genetics, Genomics, Laboratory Division, Turku University Hospital, PO Box 52, Turku, Finland4 aut |
| 700 | 1 | a Albanes, Demetriusu Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States4 aut |
| 700 | 1 | a Weinstein, Stephanie J.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States4 aut |
| 700 | 1 | a Wolk, Alicjau Department of Surgical Sciences, Uppsala University, Uppsala, Sweden4 aut |
| 700 | 1 | a West, Catharine M. L.u Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, United Kingdom4 aut |
| 700 | 1 | a Mucci, Lorelei A.u Department of Epidemiology, Harvard T. H. Chan School of Public Health, MA, Boston, United States4 aut |
| 700 | 1 | a Cancel-Tassin, Géraldineu CeRePP, Tenon Hospital, Paris, France; Sorbonne Universite, GRC n° 5, AP-HP, Tenon Hospital, 4 rue de la Chine, Paris, France4 aut |
| 700 | 1 | a Koutros, Stellau Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States4 aut |
| 700 | 1 | a Sørensen, Karina Dalsgaardu Department of Molecular Medicine, Aarhus University Hospital, Palle Juul-Jensen Boulevard 99, Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark4 aut |
| 700 | 1 | a Grindedal, Eli Marieu Department of Medical Genetics, Oslo University Hospital, Oslo, Norway4 aut |
| 700 | 1 | a Neal, David E.u Nuffield Department of Surgical Sciences, University of Oxford, Room 6603, Level 6, John Radcliffe Hospital, Headley Way, Headington, Oxford, United Kingdom; University of Cambridge, Department of Oncology, Box 279, Addenbrooke’s Hospital, Hills Road, Cambridge, United Kingdom; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom4 aut |
| 700 | 1 | a Hamdy, Freddie C.u Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; Faculty of Medical Science, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom4 aut |
| 700 | 1 | a Donovan, Jenny L.u Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom4 aut |
| 700 | 1 | a Travis, Ruth C.u Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut |
| 700 | 1 | a Hamilton, Robert J.u Department. of Surgical Oncology, Princess Margaret Cancer Centre, ON, Toronto, Canada; Department. of Surgery (Urology), University of Toronto, ON, Toronto, Canada4 aut |
| 700 | 1 | a Ingles, Sue Annu Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Rosenstein, Barry S.u Department of Radiation Oncology and Department of Genetics and Genomic Sciences, Box 1236, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, NY, New York, United States4 aut |
| 700 | 1 | a Lu, Yong-Jieu Centre for Cancer Biomarker and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, United Kingdom4 aut |
| 700 | 1 | a Giles, Graham G.u Cancer Epidemiology Division, Cancer Council Victoria, 615 St Kilda Road, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Grattan Street, VIC, Parkville, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia4 aut |
| 700 | 1 | a MacInnis, Robert J.u Cancer Epidemiology Division, Cancer Council Victoria, 615 St Kilda Road, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Grattan Street, VIC, Parkville, Australia4 aut |
| 700 | 1 | a Kibel, Adam S.u Division of Urologic Surgery, Brigham and Women’s Hospital, 75 Francis Street, MA, Boston, United States4 aut |
| 700 | 1 | a Vega, Anau Fundación Pública Galega Medicina Xenómica, Santiago de Compostela, Compostela, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Compostela, Spain; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Barcelona, Spain4 aut |
| 700 | 1 | a Kogevinas, Manolisu ISGlobal, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain4 aut |
| 700 | 1 | a Penney, Kathryn L.u Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School, MA, Boston, United States4 aut |
| 700 | 1 | a Park, Jong Y.u Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive, FL, Tampa, United States4 aut |
| 700 | 1 | a Stanford, Janet L.u Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States4 aut |
| 700 | 1 | a Cybulski, Cezaryu International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland4 aut |
| 700 | 1 | a Nordestgaard, Børge G.u Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Herlev, Denmark4 aut |
| 700 | 1 | a Nielsen, Sune F.u Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Herlev, Denmark4 aut |
| 700 | 1 | a Brenner, Hermannu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg, Germany4 aut |
| 700 | 1 | a Maier, Christianeu Humangenetik Tuebingen, Paul-Ehrlich-Str 23, Tuebingen, Germany4 aut |
| 700 | 1 | a Kim, Jeriu The University of Texas M. D. Anderson Cancer Center, Department of Genitourinary Medical Oncology, 1515 Holcombe Blvd., TX, Houston, United States4 aut |
| 700 | 1 | a John, Esther M.u Departments of Epidemiology & Population Health and of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, CA, Stanford, United States4 aut |
| 700 | 1 | a Teixeira, Manuel R.u Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal; School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal4 aut |
| 700 | 1 | a Neuhausen, Susan L.u Department of Population Sciences, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, CA, Duarte, United States4 aut |
| 700 | 1 | a De Ruyck, Kimu Ghent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences, Proeftuinstraat 86, Gent, Belgium4 aut |
| 700 | 1 | a Razack, Azadu Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia4 aut |
| 700 | 1 | a Newcomb, Lisa F.u Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Urology, University of Washington, 1959 NE Pacific Street, Box 356510, WA, Seattle, United States4 aut |
| 700 | 1 | a Lessel, Davoru Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut |
| 700 | 1 | a Kaneva, Radkau Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, 2 Zdrave Str, Sofia, Bulgaria4 aut |
| 700 | 1 | a Usmani, Nawaidu Department of Oncology, Cross Cancer Institute, University of Alberta, 11560 University Avenue, AB, Edmonton, Canada; Division of Radiation Oncology, Cross Cancer Institute, 11560 University Avenue, AB, Edmonton, Canada4 aut |
| 700 | 1 | a Claessens, Franku Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium4 aut |
| 700 | 1 | a Townsend, Paul A.u Division of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, Univeristy of Manchester, Manchester, United Kingdom; The University of Surrey, Surrey, Guildford, United Kingdom4 aut |
| 700 | 1 | a Castelao, Jose Estebanu Genetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur (IISGS), Vigo (Pontevedra), Spain4 aut |
| 700 | 1 | a Roobol, Monique J.u Department of Urology, Erasmus University Medical Center, Cancer Institute, Rotterdam, Netherlands4 aut |
| 700 | 1 | a Menegaux, Florenceu “Exposome and Heredity”, CESP (UMR 1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France4 aut |
| 700 | 1 | a Khaw, Kay-Teeu Clinical Gerontology Unit, University of Cambridge, Cambridge, United Kingdom4 aut |
| 700 | 1 | a Cannon-Albright, Lisau Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, UT, Salt Lake City, United States; George E. Wahlen Department of Veterans Affairs Medical Center, UT, Salt Lake City, United States4 aut |
| 700 | 1 | a Pandha, Hardevu The University of Surrey, Surrey, Guildford, United Kingdom4 aut |
| 700 | 1 | a Thibodeau, Stephen N.u Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States4 aut |
| 700 | 1 | a Hunter, David J.u Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut |
| 700 | 1 | a Kraft, Peteru Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, MA, Boston, United States4 aut |
| 700 | 1 | a Blot, William J.u Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 800, TN, Nashville, United States; International Epidemiology Institute, MD, Rockville, United States4 aut |
| 700 | 1 | a Riboli, Eliou Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom4 aut |
| 700 | 1 | a Day, Felix R.u MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom4 aut |
| 700 | 1 | a Wijndaele, Katrienu MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom4 aut |
| 700 | 1 | a Wareham, Nicholas J.u MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom4 aut |
| 700 | 1 | a Matthews, Charles E.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States4 aut |
| 700 | 1 | a Moore, Steven C.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States4 aut |
| 700 | 1 | a Brage, Sorenu MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom4 aut |
| 710 | 2 | a Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United Statesb MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom4 org |
| 773 | 0 | t British Journal of Cancerd : Springer Natureg 130, s. 114-124q 130<114-124x 0007-0920x 1532-1827 |
| 856 | 4 | u https://doi.org/10.1038/s41416-023-02489-3y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1819631/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-218042 |
| 856 | 4 8 | u https://doi.org/10.1038/s41416-023-02489-3 |
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