Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study

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Fältnamn	Indikatorer	Metadata
000		07078naa a2201249 4500
001		oai:DiVA.org:uu-368147
003		SwePub
008		181204s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:140739136
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3681472 URI
024	7	a https://doi.org/10.1158/1055-9965.EPI-18-00792 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1407391362 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Adams, Charleenu MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; University of Bristol, Bristol, United Kingdom.4 aut
245	1 0	a Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study
264	1	b American Association for Cancer Research (AACR),c 2019
338		a print2 rdacarrier
520		a BACKGROUND: Whether associations between circulating metabolites and prostate cancer are causal is unknown. We report on the largest study of metabolites and prostate cancer (2,291 cases and 2,661 controls) and appraise causality for a subset of the prostate cancer-metabolite associations using two-sample Mendelian randomization (MR).MATERIALS AND METHODS: The case-control portion of the study was conducted in nine UK centres with men aged 50-69 years who underwent prostate-specific antigen (PSA) screening for prostate cancer within the Prostate testing for cancer and Treatment (ProtecT) trial. Two data sources were used to appraise causality: a genome-wide association study (GWAS) of metabolites in 24,925 participants and a GWAS of prostate cancer in 44,825 cases and 27,904 controls within the Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium.RESULTS: Thirty-five metabolites were strongly associated with prostate cancer (p <0.0014, multiple-testing threshold). These fell into four classes: i) lipids and lipoprotein subclass characteristics (total cholesterol and ratios, cholesterol esters and ratios, free cholesterol and ratios, phospholipids and ratios, and triglyceride ratios); ii) fatty acids and ratios; iii) amino acids; iv) and fluid balance. Fourteen top metabolites were proxied by genetic variables, but MR indicated these were not causal.CONCLUSIONS: We identified 35 circulating metabolites associated with prostate cancer presence, but found no evidence of causality for those 14 testable with MR. Thus, the 14 MR-tested metabolites are unlikely to be mechanistically important in prostate cancer risk.IMPACT: The metabolome provides a promising set of biomarkers that may aid prostate cancer classification.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
700	1	a Richmond, Rebecca C.4 aut
700	1	a Santos Ferreira, Diana L4 aut
700	1	a Spiller, Wes4 aut
700	1	a Tan, Vanessa Y4 aut
700	1	a Zheng, Jie4 aut
700	1	a Wurtz, Peter4 aut
700	1	a Donovan, Jenny L4 aut
700	1	a Hamdy, Freddie C4 aut
700	1	a Neal, David E4 aut
700	1	a Lane, J Athene4 aut
700	1	a Davey Smith, George4 aut
700	1	a Relton, Caroline L4 aut
700	1	a Eeles, Rosalind A4 aut
700	1	a Henderson, Brian E4 aut
700	1	a Haiman, Christopher A4 aut
700	1	a Kote-Jarai, Zsofia4 aut
700	1	a Schumacher, Fredrick R4 aut
700	1	a Amin Al Olama, Ali4 aut
700	1	a Benlloch, Sara4 aut
700	1	a Muir, Kenneth4 aut
700	1	a Berndt, Sonja I4 aut
700	1	a Conti, David V4 aut
700	1	a Wiklund, Fredriku Karolinska Institutet,Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.4 aut
700	1	a Chanock, Stephen J4 aut
700	1	a Gapstur, Susan M4 aut
700	1	a Stevens, Victoria L4 aut
700	1	a Tangen, Catherine M4 aut
700	1	a Batra, Jyotsna4 aut
700	1	a Clements, Judith A4 aut
700	1	a Grönberg, Henriku Karolinska Institutet,Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.4 aut
700	1	a Pashayan, Nora4 aut
700	1	a Schleutker, Johanna4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Wolk, Alicjau Karolinska Institutet,Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.4 aut0 (Swepub:uu)alwol516
700	1	a West, Catharine M L4 aut
700	1	a Mucci, Lorelei A4 aut
700	1	a Cancel-Tassin, Geraldine4 aut
700	1	a Koutros, Stella4 aut
700	1	a Sørensen, Karina D4 aut
700	1	a Maehle, Lovise4 aut
700	1	a Travis, Ruth C4 aut
700	1	a Hamilton, Robert4 aut
700	1	a Ingles, Sue Ann4 aut
700	1	a Rosenstein, Barry S4 aut
700	1	a Lu, Yong-Jie4 aut
700	1	a Giles, Graham G4 aut
700	1	a Kibel, Adam S4 aut
700	1	a Vega, Ana4 aut
700	1	a Kogevinas, Manolis4 aut
700	1	a Penney, Kathryn L4 aut
700	1	a Park, Jong Y4 aut
700	1	a Stanford, Janet L4 aut
700	1	a Cybulski, Cezary4 aut
700	1	a Nordestgaard, Borge G4 aut
700	1	a Brenner, Hermann4 aut
700	1	a Maier, Christiane4 aut
700	1	a Kim, Jeri4 aut
700	1	a John, Esther M4 aut
700	1	a Teixeira, Manuel R4 aut
700	1	a Neuhausen, Susan L4 aut
700	1	a DeRuyck, Kim4 aut
700	1	a Razack, Azad4 aut
700	1	a Newcomb, Lisa F4 aut
700	1	a Lessel, Davor4 aut
700	1	a Kaneva, Radka P4 aut
700	1	a Usmani, Nawaid4 aut
700	1	a Claessens, Frank4 aut
700	1	a Townsend, Paul4 aut
700	1	a Gago Dominguez, Manuela4 aut
700	1	a Roobol, Monique J4 aut
700	1	a Menegaux, Florence4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Cannon-Albright, Lisa A4 aut
700	1	a Pandha, Hardev4 aut
700	1	a Thibodeau, Stephen N4 aut
700	1	a Martin, Richard M4 aut
710	2	a Karolinska Institutetb MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; University of Bristol, Bristol, United Kingdom.4 org
773	0	t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Research (AACR)g 28:1, s. 208-216q 28:1<208-216x 1055-9965x 1538-7755
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-368147
856	4 8	u https://doi.org/10.1158/1055-9965.EPI-18-0079
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:140739136

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Av författaren/redakt...: Adams, Charleen; Richmond, Rebecc ...; Santos Ferreira, ...; Spiller, Wes; Tan, Vanessa Y; Zheng, Jie; visa fler...; Wurtz, Peter; Donovan, Jenny L; Hamdy, Freddie C; Neal, David E; Lane, J Athene; Davey Smith, Geo ...; Relton, Caroline ...; Eeles, Rosalind ...; Henderson, Brian ...; Haiman, Christop ...; Kote-Jarai, Zsof ...; Schumacher, Fred ...; Amin Al Olama, A ...; Benlloch, Sara; Muir, Kenneth; Berndt, Sonja I; Conti, David V; Wiklund, Fredrik; Chanock, Stephen ...; Gapstur, Susan M; Stevens, Victori ...; Tangen, Catherin ...; Batra, Jyotsna; Clements, Judith ...; Grönberg, Henrik; Pashayan, Nora; Schleutker, Joha ...; Albanes, Demetri ...; Wolk, Alicja; West, Catharine ...; Mucci, Lorelei A; Cancel-Tassin, G ...; Koutros, Stella; Sørensen, Karina ...; Maehle, Lovise; Travis, Ruth C; Hamilton, Robert; Ingles, Sue Ann; Rosenstein, Barr ...; Lu, Yong-Jie; Giles, Graham G; Kibel, Adam S; Vega, Ana; Kogevinas, Manol ...; Penney, Kathryn ...; Park, Jong Y; Stanford, Janet ...; Cybulski, Cezary; Nordestgaard, Bo ...; Brenner, Hermann; Maier, Christian ...; Kim, Jeri; John, Esther M; Teixeira, Manuel ...; Neuhausen, Susan ...; DeRuyck, Kim; Razack, Azad; Newcomb, Lisa F; Lessel, Davor; Kaneva, Radka P; Usmani, Nawaid; Claessens, Frank; Townsend, Paul; Gago Dominguez, ...; Roobol, Monique ...; Menegaux, Floren ...; Khaw, Kay-Tee; Cannon-Albright, ...; Pandha, Hardev; Thibodeau, Steph ...; Martin, Richard ...; visa färre...

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