Sökning: WFRF:(Levison Steven W) > (2011) > Pitfalls in the Que...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04042naa a2200445 4500 | |
001 | oai:gup.ub.gu.se/147459 | |
003 | SwePub | |
008 | 240528s2011 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/1474592 URI |
024 | 7 | a https://doi.org/10.1159/0003331092 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gressens, Pierre4 aut |
245 | 1 0 | a Pitfalls in the Quest of Neuroprotectants for the Perinatal Brain. |
264 | c 2011-09-30 | |
264 | 1 | b S. Karger AG,c 2011 |
520 | a Sick preterm and term newborns are highly vulnerable to neural injury, and thus there has been a major search for new, safe and efficacious neuroprotective interventions in recent decades. Preclinical studies are essential to select candidate drugs for clinical trials in humans. This article focuses on 'negative' preclinical studies, i.e. studies where significant differences cannot be detected. Such findings are critical to inform both clinical and preclinical investigators, but historically they have been difficult to publish. A significant amount of time and resources is lost when negative results or nonpromising therapeutics are replicated in separate laboratories because these negative results were not shared with the research community in an open and accessible format. In this article, we discuss approaches to strengthen conclusions from negative preclinical studies and, conversely, to reduce false-negative preclinical evaluations of potential therapeutic compounds. Without being exhaustive, we address three major issues in conducting and interpreting preclinical experiments, including: (a) the choice of animal models, (b) the experimental design, and (c) issues concerning statistical analyses of the experiments. This general introduction is followed by synopses of negative data obtained from studies of three potential therapeutics for perinatal brain injury: (1) the somatostatin analog octreotide, (2) an AMPA/kainate receptor antagonist, topiramate, and (3) a pyruvate derivative, ethyl pyruvate. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
700 | 1 | a Le Verche, Virginia4 aut |
700 | 1 | a Fraser, Mhoyra4 aut |
700 | 1 | a Rousset, Catherine I4 aut |
700 | 1 | a Schwendimann, Leslie4 aut |
700 | 1 | a Bennet, Laura4 aut |
700 | 1 | a George, Sherly A4 aut |
700 | 1 | a Wang, Xiaoyang,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation4 aut0 (Swepub:gu)xwanxi |
700 | 1 | a Mallard, Carina,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xmallc |
700 | 1 | a Tilley, Barbara C4 aut |
700 | 1 | a Dournaud, Pascal4 aut |
700 | 1 | a Gunn, Alistair Jan4 aut |
700 | 1 | a Hagberg, Henrik,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xhaghe |
700 | 1 | a Levison, Steven W4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering4 org |
773 | 0 | t Developmental neuroscienced : S. Karger AGg 33:3-4, s. 189-198q 33:3-4<189-198x 1421-9859x 0378-5866 |
856 | 4 | u https://www.karger.com/Article/Pdf/333109 |
856 | 4 8 | u https://gup.ub.gu.se/publication/147459 |
856 | 4 8 | u https://doi.org/10.1159/000333109 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.