Sökning: WFRF:(Lewis Sarah J.) > (2003-2004) > Genome scan meta-an...
Fältnamn | Indikatorer | Metadata |
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000 | 05460naa a2201057 4500 | |
001 | oai:DiVA.org:uu-72473 | |
003 | SwePub | |
008 | 050524s2003 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-724732 URI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lewis, Cathryn M4 aut |
245 | 1 0 | a Genome scan meta-analysis of schizophrenia and bipolar disorder, part II :b Schizophrenia |
264 | 1 | c 2003 |
338 | a print2 rdacarrier | |
520 | a Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across studies (R(avg)) and then weighted for sample size (N(sqrt)[affected casess]). A permutation test was used to compute the probability of observing, by chance, each bin's average rank (P(AvgRnk)) or of observing it for a bin with the same place (first, second, etc.) in the order of average ranks in each permutation (P(ord)). The GSMA produced significant genomewide evidence for linkage on chromosome 2q (PAvgRnk<.000417). Two aggregate criteria for linkage were also met (clusters of nominally significant P values that did not occur in 1,000 replicates of the entire data set with no linkage present): 12 consecutive bins with both P(AvgRnk) and P(ord)<.05, including regions of chromosomes 5q, 3p, 11q, 6p, 1q, 22q, 8p, 20q, and 14p, and 19 consecutive bins with P(ord)<.05, additionally including regions of chromosomes 16q, 18q, 10p, 15q, 6q, and 17q. There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
653 | a Bipolar Disorder/*genetics | |
653 | a Genome; Human | |
653 | a Genotype | |
653 | a Humans | |
653 | a Research Support; Non-U.S. Gov't | |
653 | a Research Support; U.S. Gov't; Non-P.H.S. | |
653 | a Research Support; U.S. Gov't; P.H.S. | |
653 | a Schizophrenia/*genetics | |
653 | a Neurobiology | |
653 | a Neurobiologi | |
653 | a Genetics | |
653 | a Genetik | |
700 | 1 | a Levinson, Douglas F4 aut |
700 | 1 | a Wise, Lesley H4 aut |
700 | 1 | a DeLisi, Lynn E4 aut |
700 | 1 | a Straub, Richard E4 aut |
700 | 1 | a Hovatta, Iiris4 aut |
700 | 1 | a Williams, Nigel M4 aut |
700 | 1 | a Schwab, Sibylle G4 aut |
700 | 1 | a Pulver, Ann E4 aut |
700 | 1 | a Faraone, Stephen V4 aut |
700 | 1 | a Brzustowicz, Linda M4 aut |
700 | 1 | a Kaufmann, Charles A4 aut |
700 | 1 | a Garver, David L4 aut |
700 | 1 | a Gurling, Hugh M D4 aut |
700 | 1 | a Lindholm, Evau Uppsala universitet,Evolutionsbiologi,Behavioral Genetics4 aut |
700 | 1 | a Coon, Hilary4 aut |
700 | 1 | a Moises, Hans W4 aut |
700 | 1 | a Byerley, William4 aut |
700 | 1 | a Shaw, Sarah H4 aut |
700 | 1 | a Mesen, Andrea4 aut |
700 | 1 | a Sherrington, Robin4 aut |
700 | 1 | a O'Neill, F Anthony4 aut |
700 | 1 | a Walsh, Dermot4 aut |
700 | 1 | a Kendler, Kenneth S4 aut |
700 | 1 | a Ekelund, Jesper4 aut |
700 | 1 | a Paunio, Tiina4 aut |
700 | 1 | a Lännqvist, Jouko4 aut |
700 | 1 | a Peltonen, Leena4 aut |
700 | 1 | a O'Donovan, Michael C4 aut |
700 | 1 | a Owen, Michael J4 aut |
700 | 1 | a Wildenauer, Dieter B4 aut |
700 | 1 | a Maier, Wolfgang4 aut |
700 | 1 | a Nestadt, Gerald4 aut |
700 | 1 | a Blouin, Jean-Louis4 aut |
700 | 1 | a Antonarakis, Stylianos E4 aut |
700 | 1 | a Mowry, Bryan J4 aut |
700 | 1 | a Silverman, Jeremy M4 aut |
700 | 1 | a Crowe, Raymond R4 aut |
700 | 1 | a Cloninger, C Robert4 aut |
700 | 1 | a Tsuang, Ming T4 aut |
700 | 1 | a Malaspina, Dolores4 aut |
700 | 1 | a Harkavy-Friedman, Jill M4 aut |
700 | 1 | a Svrakic, Dragan M4 aut |
700 | 1 | a Bassett, Anne S4 aut |
700 | 1 | a Holcomb, Jennifer4 aut |
700 | 1 | a Kalsi, Gursharan4 aut |
700 | 1 | a McQuillin, Andrew4 aut |
700 | 1 | a Brynjolfson, Jon4 aut |
700 | 1 | a Sigmundsson, Thordur4 aut |
700 | 1 | a Petursson, Hannes4 aut |
700 | 1 | a Jazin, Elenau Behavioral Genetics4 aut0 (Swepub:uu)elenjazi |
700 | 1 | a Zoëga, Tomas4 aut |
700 | 1 | a Helgason, Tomas4 aut |
710 | 2 | a Uppsala universitetb Evolutionsbiologi4 org |
773 | 0 | t American Journal of Human Geneticsg 73:1, s. 34-48q 73:1<34-48x 0002-9297x 1537-6605 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=12802786&dopt=Citation |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72473 |
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