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Overexpression of c...
Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients
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Tian, Chao (author)
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Zhou, Zong-Guang (author)
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Meng, Wen-Jian (author)
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- Sun, Xiao-Feng, 1959- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US
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Yu, Yong-Yang (author)
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Li, Li (author)
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Luo, Hong-Zhi (author)
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Yang, Lie (author)
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Zhou, Bin (author)
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Gu, Jun (author)
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: World Journal of Gastroenterology. - 1007-9327 .- 2219-2840. ; 13:28, s. 3878-3882
- Related links:
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https://urn.kb.se/re...
Abstract
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- Aim: To clarify the expression change of Wnt-induced secreted protein-1 (WISP-1) in human rectal cancer and to determine whether it is correlated with invasion and metastasis of human rectal cancer. Methods: Eighty-six paired samples of rectal cancer and surgically resected distant normal rectal tissue were collected and allocated into cancer group and control group respectively. WISP-1 mRNA was detected by relative quantitative real-time RT-PCR and WISP-1 protein was examined by immunohistochemical staining. Results: WISP-1 gene overexpression was found in 65% (56/86) primary rectal cancers, 2-30 times that of the level in normal matched rectal tissues (P = 0.001). The mRNA expression level was correlated with Duke's staging, histological differentiation grade and lymph node status. The WISP-1 protein expression was in accordance with mRNA expression level. The positive degree of immunohistochemical staining in the cancer group (1.40 ± 0.35) was different from that in control group (1.04 ± 0.08, P < 0.001). Moreover, in cancer group the positive staining degree in high-level mRNA cancers (1.46 ± 0.37, n = 56) was higher than that in low-level mRNA (1.28 ± 0.28, n = 30, P = 0.018). Conclusion: Aberrant levels of WISP-1 expression may play a role in rectal tumorigenesis. WISP-1 may be used as a specific clinical diagnosis and prognosis marker in rectal cancer. © 2007 WJG. All rights reserved.
Keyword
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Tian, Chao
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Zhou, Zong-Guang
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Meng, Wen-Jian
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Sun, Xiao-Feng, ...
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Yu, Yong-Yang
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Li, Li
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show more...
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Luo, Hong-Zhi
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Yang, Lie
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Zhou, Bin
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Gu, Jun
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World Journal of ...
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Linköping University