Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients

Aim: To clarify the expression change of Wnt-induced secreted protein-1 (WISP-1) in human rectal cancer and to determine whether it is correlated with invasion and metastasis of human rectal cancer. Methods: Eighty-six paired samples of rectal cancer and surgically resected distant normal rectal tissue were collected and allocated into cancer group and control group respectively. WISP-1 mRNA was detected by relative quantitative real-time RT-PCR and WISP-1 protein was examined by immunohistochemical staining. Results: WISP-1 gene overexpression was found in 65% (56/86) primary rectal cancers, 2-30 times that of the level in normal matched rectal tissues (P = 0.001). The mRNA expression level was correlated with Duke's staging, histological differentiation grade and lymph node status. The WISP-1 protein expression was in accordance with mRNA expression level. The positive degree of immunohistochemical staining in the cancer group (1.40 ± 0.35) was different from that in control group (1.04 ± 0.08, P < 0.001). Moreover, in cancer group the positive staining degree in high-level mRNA cancers (1.46 ± 0.37, n = 56) was higher than that in low-level mRNA (1.28 ± 0.28, n = 30, P = 0.018). Conclusion: Aberrant levels of WISP-1 expression may play a role in rectal tumorigenesis. WISP-1 may be used as a specific clinical diagnosis and prognosis marker in rectal cancer. © 2007 WJG. All rights reserved.

Zhou, Zong-Guang (författare)
Meng, Wen-Jian (författare)
Sun, Xiao-Feng,1959-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US(Swepub:liu)xiasu45 (författare)
Yu, Yong-Yang (författare)
Li, Li (författare)
Luo, Hong-Zhi (författare)
Yang, Lie (författare)
Zhou, Bin (författare)
Gu, Jun (författare)
Linköpings universitetHälsouniversitetet (creator_code:org_t)

Av författaren/redakt...: Tian, Chao; Zhou, Zong-Guang; Meng, Wen-Jian; Sun, Xiao-Feng, ...; Yu, Yong-Yang; Li, Li; visa fler...; Luo, Hong-Zhi; Yang, Lie; Zhou, Bin; Gu, Jun; visa färre...

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