WFRF:(Li Xingru)
Sökning: WFRF:(Li Xingru) > (2012-2014) > Prognostic signific...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03661naa a2200469 4500 | |
| 001 | oai:DiVA.org:umu-100163 | |
| 003 | SwePub | |
| 008 | 150224s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1001632 URI |
| 024 | 7 | a https://doi.org/10.1002/cam4.2442 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Andersson, Charlottau Umeå universitet,Patologi4 aut0 (Swepub:umu)chan0062 |
| 245 | 1 0 | a Prognostic significance of specific anti-WT1 IgG antibody level in plasma in patients with ovarian carcinoma |
| 264 | c 2014-04-08 | |
| 264 | 1 | b Wiley,c 2014 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Ovarian carcinoma (OC) has a poor prognosis and lack early effective screening markers. Wilm's tumor gene 1 (WT1) is overexpressed in OCs. Therefore, it is of great interest to investigate whether WT1-specific antibody (Ab) measurements in plasma can serve as a biomarker of anti-OC response, and is of importance in relation to patient prognosis. Peripheral blood samples were obtained from a total of 103 women with ovarian tumors with median being 1 day (range 0-48 days) before operation. WT1 IgG Ab levels were evaluated using enzyme-linked immunosorbent assay (ELISA). Immunohistochemical analysis of WT1 protein expression was performed on OC tissue samples. We found that low-WT1 Ab level in plasma was related to improved survival in patients diagnosed at stages III-IV and grade 3 carcinomas. Positive WT1 protein staining on OC tissue samples had a negative impact on survival in the entire cohort, both overall survival (OS) (P = 0.046) and progression-free survival (PFS) (P = 0.006), but not in the serous OC subtype. Combining WT1 IgG Ab levels and WT1 staining, patients with high-WT1 IgG Ab levels in plasma and positive WT1 protein staining in cancer tissues had shorter survival, with a significant association in PFS (P = 0.016). These results indicated that WT1 Ab measurements in plasma and WT1 staining in tissue specimens could be useful as biomarkers for patient outcome in the high-risk subtypes of OCs for postoperative individualized therapy. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a Ovarian carcinoma | |
| 653 | a prognosis | |
| 653 | a WT1 | |
| 653 | a WT1 IgG antibody | |
| 700 | 1 | a Oji, Yusuke4 aut |
| 700 | 1 | a Ohlson, Ninau Umeå universitet,Patologi4 aut0 (Swepub:umu)niaohn95 |
| 700 | 1 | a Wang, Sihanu Umeå universitet,Patologi4 aut0 (Swepub:umu)siwa0003 |
| 700 | 1 | a Li, Xingruu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)xili0010 |
| 700 | 1 | a Ottander, Ulrikau Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)ulaotr95 |
| 700 | 1 | a Lundin, Evau Umeå universitet,Patologi4 aut0 (Swepub:umu)evlu0001 |
| 700 | 1 | a Sugiyama, Haruo4 aut |
| 700 | 1 | a Li, Aihongu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)liai0001 |
| 710 | 2 | a Umeå universitetb Patologi4 org |
| 773 | 0 | t Cancer Medicined : Wileyg 3:4, s. 909-918q 3:4<909-918x 2045-7634 |
| 856 | 4 | u https://doi.org/10.1002/cam4.244y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:790413/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.244 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100163 |
| 856 | 4 8 | u https://doi.org/10.1002/cam4.244 |
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