A screening method to spot biomarkers that may warn of serious events in a chronic disease - illustrated by cardiological CLARICOR trial data

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A screening method to spot biomarkers that may warn of serious events in a chronic disease - illustrated by cardiological CLARICOR trial data

Winkel, Per (författare): Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Hilden, Jørgen (författare): Department of Public Health Research, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark.

Jakobsen, Janus Christian (författare): Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

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Lindschou, Jane (författare): Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Jensen, Gorm Boje (författare): Department of Cardiology, Hvidovre Hospital, Copenhagen University Hospital, Copenhagen, Denmark.

Kjøller, Erik (författare): Department of Cardiology S, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.

Sajadieh, Ahmad (författare): Department of Cardiology, Bispebjerg Hospital, University Hospital, Copenhagen, Denmark

Kastrup, Jens (författare): Department of Cardiology B, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Kolmos, Hans Jørn (författare): Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark.

Larsson, Anders (författare): Uppsala universitet,Klinisk kemi

Ärnlöv, Johan (författare): Karolinska Institutet,Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institute, Huddinge, Sweden.

Bjerre, Mette (författare): Department of Clinical Medicine, The Medical Research Laboratory, Aarhus University, Aarhus, Denmark.

Gluud, Christian (författare): Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

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Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Department of Public Health Research, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark. (creator_code:org_t)

2021-08-12
2021
Engelska.
Ingår i: Clinical Chemistry and Laboratory Medicine. - : Walter de Gruyter. - 1434-6621 .- 1437-4331. ; 59:11, s. 1852-1860

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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OBJECTIVES: To develop a crude screening method for detecting biomarkers which frequently exhibit a rise (or fall) in level prior to a serious event (e.g. a stroke) in patients with a chronic disease, signalling that the biomarker may have an alarm-raising or prognostic potential. The subsequent assessment of the marker's clinical utility requires costly, difficult longitudinal studies. Therefore, initial screening of candidate-biomarkers is desirable.METHODS: The method exploits a cohort of patients with biomarkers measured at entry and with recording of first serious event during follow-up. Copying those individual records onto a common timeline where a specific event occurs on the same day (Day 0) for all patients, the baseline biomarker level, when plotted against the patient's entry time on the revised timeline, will have a positive (negative) regression slope if biomarker levels generally rise (decline) the closer one gets to the event. As an example, we study 1,958 placebo-treated patients with stable coronary artery disease followed for nine years in the CLARICOR trial (NCT00121550), examining 11 newer biomarkers.RESULTS: Rising average serum levels of cardiac troponin T and of N-terminal pro-B-type natriuretic peptide were seen prior to a fatal cardiovascular outcome. C-reactive protein rose prior to non-cardiovascular death. Glomerular filtration rate, seven lipoproteins, and nine newer cardiological biomarkers did not show convincing changes.CONCLUSIONS: For early detection of biomarkers with an alarm-raising potential in chronic diseases, we proposed the described easy procedure. Using only baseline biomarker values and clinical course of participants with coronary heart disease, we identified the same cardiovascular biomarkers as those previously found containing prognostic information using longitudinal or survival analysis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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biomarkers
cardiology
control charts
personalized medicine
reverse alignment

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Av författaren/redakt...: Winkel, Per; Hilden, Jørgen; Jakobsen, Janus ...; Lindschou, Jane; Jensen, Gorm Boj ...; Kjøller, Erik; visa fler...; Sajadieh, Ahmad; Kastrup, Jens; Kolmos, Hans Jør ...; Larsson, Anders; Ärnlöv, Johan; Bjerre, Mette; Gluud, Christian; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

Artiklar i publikationen: Clinical Chemist ...

Av lärosätet: Uppsala universitet; Karolinska Institutet

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