WFRF:(Lindsten T.)
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Interaction by cholestyramine on the uptake of hydrocortisone in the gastrointestinal tract.
- Johansson, C (author)
- Adamsson, U (author)
-
- Stierner, Ulrika, 1952 (author)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Lindsten, T (author)
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- (creator_code:org_t)
- 1978
- 1978
- English.
- In: Acta medica Scandinavica. - 0001-6101. ; 204:6, s. 509-12
- Journal article (peer-reviewed)
Abstract
Subject headings
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- An absolute reduction of the plasma cortisol levels and a delay of the peak concentrations were recorded in 10 healthy subjects, when a bile-sequestering anionic exchange resin, cholestyramine, was given prior to a single oral hydrocortisone dose, indicating that the resin interferes with the uptake of a neutral sterol in the human gastrointestinal tract. The possibility of a direct binding of drug to resin is supported by the affinity of hydrocortisone to cholestyramine in vitro, which was uninfluenced by the presence of sodium taurocholate. Cholestyramine significantly delayed the gastric emptying of a glucose solution, indicating that the resin not only decreases but also delays hydrocortisone absorption. Careful supervision is recommended when treatment with cholestyramine is given concomitant to neutral sterol drugs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Cholestyramine Resin
- administration & dosage
- pharmacology
- Dose-Response Relationship
- Drug
- Drug Interactions
- Gastric Emptying
- drug effects
- Humans
- Hydrocortisone
- administration & dosage
- blood
- metabolism
- Intestinal Absorption
- drug effects
- Taurocholic Acid
- pharmacology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- University of Gothenburg
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