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WFRF:(Lister T Andrew)
 

Sökning: WFRF:(Lister T Andrew) > (1992-1994) > Diagnosis of acute ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003281naa a2200421 4500
001oai:lup.lub.lu.se:41a841f9-4a61-4865-b972-5df99b8e9743
003SwePub
008160401s1992 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/11069202 URI
0247 a https://doi.org/10.1111/j.1365-2141.1992.tb06463.x2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Borrow, Julian4 aut
2451 0a Diagnosis of acute promyelocytic leukaemia by RT-PCR: detection of PML-RARA and RARA-PML fusion transcripts
264 1b Wiley,c 1992
520 a Acute promyelocytic leukaemia (APL; AML M3) is identified by a unique t(15;17) translocation which fuses the PML gene to the retinoic acid receptor alpha gene (RARA). Reverse transcription coupled with the polymerase chain reaction (RT-PCR) has been used to develop a diagnostic test for APL based on the PML-RARA fusion message. Separate PCR assays were designed to amplify either PML-RARA (15q+ derived) or RARA-PML (17q- derived) chimaeric transcripts. PML-RARA transcripts were detected in every case from a series of 18 APL patients with cytogenetically confirmed t(15;17) translocations, whereas RARA-PML messages were detected in only 67% (12/18) of these patients. This suggests that it is the 15q+ derivative which mediates leukaemogenesis. Furthermore the PCR approach (or Southern analysis) may be used to identify in which of the alternative PML introns the breakpoint occurs; 52% of cases (15/29 patients) utilize a 5' PML intron and 48% the 3' intron (14/29 cases). Neither the choice of PML intron nor the expression of the 17q- derivative could be correlated with the microgranular variant of APL (M3V), overall survival rate, age, sex or presence of coagulopathy. Finally, the fusion message is undetectable in five remission samples. This indicates a possible use for RT-PCR in monitoring remission patients for evidence of relapse.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
7001 a Goddard, Audrey D4 aut
7001 a Gibbons, Barbara4 aut
7001 a Katz, Fay4 aut
7001 a Swirsky, David4 aut
7001 a Fioretos, Thoasu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-tfi
7001 a Dube, Ian4 aut
7001 a Winfield, David A4 aut
7001 a Kingston, Judith4 aut
7001 a Hagemeijer, Anne4 aut
7001 a Rees, John K H4 aut
7001 a Lister, T Andrew4 aut
7001 a Solomon, Ellen4 aut
7102 a Avdelningen för klinisk genetikb Institutionen för laboratoriemedicin4 org
7730 t British Journal of Haematologyd : Wileyg 82:3, s. 529-540q 82:3<529-540x 0007-1048x 1365-2141
8564 u http://dx.doi.org/10.1111/j.1365-2141.1992.tb06463.xy FULLTEXT
8564 8u https://lup.lub.lu.se/record/1106920
8564 8u https://doi.org/10.1111/j.1365-2141.1992.tb06463.x

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