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Sökning: WFRF:(Lo Tsz Yan Milly) > (2018) > Visualizing Cerebro...

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FältnamnIndikatorerMetadata
00006268naa a2200565 4500
001oai:DiVA.org:uu-425415
003SwePub
008201119s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4254152 URI
0247 a https://doi.org/10.1007/978-3-319-65798-1_572 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a kon2 swepub-publicationtype
1001 a Flechet, Marineu Univ Hosp Leuven, Dept Intens Care Med, Leuven, Belgium.;Univ Klinikum Tubingen, Klin Neurochirurg, Tubingen, Germany.;Univ Glasgow, Sch Math & Stat, Glasgow, Lanark, Scotland.;NHS Greater Glasgow & Clyde, Dept Clin Phys & Bioengn, Glasgow, Lanark, Scotland.;Univ Hosp Leuven, Dept Neurosurg, Leuven, Lanark, Belgium.4 aut
2451 0a Visualizing Cerebrovascular Autoregulation Insults and Their Association with Outcome in Adult and Paediatric Traumatic Brain Injury
264 c 2018-03-01
264 1a Cham :b Springer Nature,c 2018
338 a print2 rdacarrier
520 a Objective: The aim of this study is to assess visually the impact of duration and intensity of cerebrovascular autoregulation insults on 6-month neurological outcome in severe traumatic brain injury.Material and methods: Retrospective analysis of prospectively collected minute-by-minute intracranial pressure (ICP) and mean arterial blood pressure data of 259 adult and 99 paediatric traumatic brain injury (TBI) patients from multiple European centres. The relationship of the 6-month Glasgow Outcome Scale with cerebrovascular autoregulation insults (defined as the low-frequency autoregulation index above a certain threshold during a certain time) was visualized in a colour-coded plot. The analysis was performed separately for autoregulation insults occurring with cerebral perfusion pressure (CPP) below 50 mmHg, with ICP above 25 mmHg and for the subset of adult patients that did not undergo decompressive craniectomy.Results: The colour-coded plots showed a time-intensity-dependent association with outcome for cerebrovascular autoregulation insults in adult and paediatric TBI patients. Insults with a low-frequency autoregulation index above 0.2 were associated with worse outcomes and below -0.6 with better outcomes, with and approximately exponentially decreasing transition curve between the two intensity thresholds. All insults were associated with worse outcomes when CPP was below 50 mmHg or ICP was above 25 mmHg.Conclusions: The colour-coded plots indicate that cerebrovascular autoregulation is disturbed in a dynamic manner, such that duration and intensity play a role in the determination of a zone associated with better neurological outcome.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a Traumatic brain injury
653 a Cerebrovascular autoregulation
653 a Autoregulation index
653 a Visualization
653 a Adults
653 a Children
7001 a Meyfroidt, Geertu Univ Hosp Leuven, Dept Intens Care Med, Leuven, Belgium.;Univ Klinikum Tubingen, Klin Neurochirurg, Tubingen, Germany.;Univ Glasgow, Sch Math & Stat, Glasgow, Lanark, Scotland.;NHS Greater Glasgow & Clyde, Dept Clin Phys & Bioengn, Glasgow, Lanark, Scotland.;Univ Hosp Leuven, Dept Neurosurg, Leuven, Lanark, Belgium.4 aut
7001 a Piper, Ianu Southern Gen Hosp, Dept Clin Phys, Glasgow, Lanark, Scotland.4 aut
7001 a Citerio, Giuseppeu San Gerardo Hosp, Monza, Italy.4 aut
7001 a Chambers, Iainu James Cook Univ Hosp, Med Phys, Middlesbroughnza, England.4 aut
7001 a Jones, Patricia A.u Royal Hosp Sick Children, Dept Paediat Neurol, Edinburgh, Midlothian, Scotland.4 aut
7001 a Lo, Tsz-Yan Millyu Royal Hosp Sick Children, Dept Paediat Intens Care, Edinburgh, Midlothian, Scotland.4 aut
7001 a Enblad, Peru Uppsala universitet,Enblad: Neurokirurgi4 aut0 (Swepub:uu)perenbla
7001 a Nilsson, Pelleu Uppsala universitet,Enblad: Neurokirurgi4 aut0 (Swepub:uu)pellnils
7001 a Feyen, Bartu Antwerp Univ Hosp, Dept Neurosurg, Edegem, Belgium.4 aut
7001 a Jorens, Philippeu Antwerp Univ Hosp, Dept Intens Care Med, Edegem, Belgium.4 aut
7001 a Maas, Andrewu Antwerp Univ Hosp, Dept Neurosurg, Edegem, Belgium.4 aut
7001 a Schuhmann, Martin U.u Univ Klinikum Tubingen, Klin Neurochirurg, Tubingen, Germany.4 aut
7001 a Donald, Robu Univ Glasgow, Sch Math & Stat, Glasgow, Lanark, Scotland.4 aut
7001 a Moss, Laurau NHS Greater Glasgow & Clyde, Dept Clin Phys & Bioengn, Glasgow, Lanark, Scotland.4 aut
7001 a Van den Berghe, Greetu Univ Hosp Leuven, Dept Intens Care Med, Leuven, Belgium.;Univ Klinikum Tubingen, Klin Neurochirurg, Tubingen, Germany.;Univ Glasgow, Sch Math & Stat, Glasgow, Lanark, Scotland.;NHS Greater Glasgow & Clyde, Dept Clin Phys & Bioengn, Glasgow, Lanark, Scotland.;Univ Hosp Leuven, Dept Neurosurg, Leuven, Lanark, Belgium.4 aut
7001 a Depreitere, Bartu Univ Hosp Leuven, Dept Neurosurg, Leuven, Lanark, Belgium.4 aut
7001 a Guiza, Fabianu Univ Hosp Leuven, Dept Intens Care Med, Leuven, Belgium.;Univ Klinikum Tubingen, Klin Neurochirurg, Tubingen, Germany.;Univ Glasgow, Sch Math & Stat, Glasgow, Lanark, Scotland.;NHS Greater Glasgow & Clyde, Dept Clin Phys & Bioengn, Glasgow, Lanark, Scotland.;Univ Hosp Leuven, Dept Neurosurg, Leuven, Lanark, Belgium.4 aut
7102 a Univ Hosp Leuven, Dept Intens Care Med, Leuven, Belgium.;Univ Klinikum Tubingen, Klin Neurochirurg, Tubingen, Germany.;Univ Glasgow, Sch Math & Stat, Glasgow, Lanark, Scotland.;NHS Greater Glasgow & Clyde, Dept Clin Phys & Bioengn, Glasgow, Lanark, Scotland.;Univ Hosp Leuven, Dept Neurosurg, Leuven, Lanark, Belgium.b Southern Gen Hosp, Dept Clin Phys, Glasgow, Lanark, Scotland.4 org
7730 t Intracranial pressure &amp; neuromonitoring XVId Cham : Springer Natureg , s. 291-295q <291-295z 9783319657981z 9783319657974
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-425415
8564 8u https://doi.org/10.1007/978-3-319-65798-1_57

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