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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003661naa a2200445 4500
001oai:prod.swepub.kib.ki.se:1932846
003SwePub
008240701s2000 | |||||||||||000 ||eng|
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19328462 URI
0247 a https://doi.org/10.1097/00004647-200002000-000032 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Abi-Dargham, A4 aut
2451 0a Measurement of striatal and extrastriatal dopamine D1 receptor binding potential with [11C]NNC 112 in humans: validation and reproducibility
264 c 2016-08-31
264 1b SAGE Publications,c 2000
520 a To evaluate the postulated role of extrastriatal D1 receptors in human cognition and psychopathology requires an accurate and reliable method for quantification of these receptors in the living human brain. [11C]NNC 112 is a promising novel radiotracer for positron emission tomography imaging of the D1 receptor. The goal of this study was to develop and evaluate methods to derive D1 receptor parameters in striatal and extrastriatal regions of the human brain with [11C]NNC 112. Six healthy volunteers were studied twice. Two methods of analysis (kinetic and graphical) were applied to 12 regions (neocortical, limbic, and subcortical regions) to derive four outcome measures: total distribution volume, distribution volume ratio, binding potential (BP), and specific-to-nonspecific equilibrium partition coefficient ( k3/ k4). Both kinetic and graphic analyses provided BP and k3/ k4 values in good agreement with the known distribution of D1 receptors (striatum > limbic regions = neocortical regions > thalamus). The identifiability of outcome measures derived by kinetic analysis was excellent. Time-stability analysis indicated that 90 minutes of data collection generated stable outcome measures. Derivation of BP and k3/ k4 by kinetic analysis was highly reliable, with intraclass correlation coefficients (ICCs) of 0.90 ± 0.06 (mean ± SD of 12 regions) and 0.84 ± 0.11, respectively. The reliability of these parameters derived by graphical analysis was lower, with ICCs of 0.72 ± 0.17 and 0.58 ± 0.21, respectively. Noise analysis revealed a noise-dependent bias in the graphical but not the kinetic analysis. In conclusion, kinetic analysis of [11C]NNC 112 uptake provides an appropriate method with which to derive D1 receptor parameters in regions with both high (striatal) and low (extrastriatal) D1 receptor density.
7001 a Martinez, D4 aut
7001 a Mawlawi, O4 aut
7001 a Simpson, N4 aut
7001 a Hwang, DR4 aut
7001 a Slifstein, M4 aut
7001 a Anjilvel, S4 aut
7001 a Pidcock, J4 aut
7001 a Guo, NN4 aut
7001 a Lombardo, I4 aut
7001 a Mann, JJ4 aut
7001 a Van Heertum, R4 aut
7001 a Foged, C4 aut
7001 a Halldin, Cu Karolinska Institutet4 aut
7001 a Laruelle, M4 aut
7102 a Karolinska Institutet4 org
7730 t Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolismd : SAGE Publicationsg 20:2, s. 225-243q 20:2<225-243x 0271-678X
7730 t Journal of Cerebral Blood Flow & Metabolismd : SAGE Publicationsg 20:2, s. 225-243q 20:2<225-243x 1559-7016
8564 u https://journals.sagepub.com/doi/pdf/10.1097/00004647-200002000-00003
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1932846
8564 8u https://doi.org/10.1097/00004647-200002000-00003

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