SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Ludvigsson Jonas F.)
 

Sökning: WFRF:(Ludvigsson Jonas F.) > Tumour necrosis fac...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008575naa a2200745 4500
001oai:lup.lub.lu.se:adef9445-08f0-4d3e-a5cc-b897f3105e60
003SwePub
008220302s2022 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-97265
009oai:DiVA.org:liu-182749
009oai:prod.swepub.kib.ki.se:148603714
0247 a https://lup.lub.lu.se/record/adef9445-08f0-4d3e-a5cc-b897f3105e602 URI
0247 a https://doi.org/10.1111/codi.160212 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-972652 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1827492 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1486037142 URI
040 a (SwePub)lud (SwePub)orud (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Eberhardson, Michaelu Karolinska Institutet,Linköpings universitet,Linköping University,Karolinska Institute,Department of Gastroenterology and Hepatology, University Hospital, Linköping, Sweden; Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken,Karolinska Inst, Sweden4 aut0 (Swepub:liu)miceb31
2451 0a Tumour necrosis factor inhibitors in Crohn's disease and the effect on surgery rates
264 c 2022-01-22
264 1b Wiley,c 2022
500 a Funding Agencies|Bengt Ihre Research Fellowship; Stockholm County Council ALFStockholm County Council [20180565, 20170720, 20190638]; SFO Young Scholar Award at Karolinska Institutet; Swedish Research CouncilSwedish Research CouncilEuropean Commission [2020-02002]; Swedish Society of Medicine; Bengt Ihre Fellowship; Stockholm County Council postdoctoral fellowship; Bengt Ihre Foundation
520 a Aim: Surgery is an important therapeutic option for Crohn's disease. The need for first bowel surgery seems to have decreased with the introduction of tumour necrosis factor inhibitors (TNFi; adalimumab or infliximab). However, the impact of TNFi on the need for intestinal surgery in Crohn's disease patients irrespective of prior bowel resection is not known. The aim of this work is to compare the incidence of bowel surgery in Crohn's disease patients who remain on TNFi treatment versus those who discontinue it. Method: We performed a nationwide register-based observational cohort study in Sweden of all incident and prevalent cases of Crohn's disease who started first-line TNFi treatment between 2006 and 2017. Patients were categorized according to TNFi treatment retention less than or beyond 1 year. The study cohort was evaluated with regard to incidence of bowel surgery from 12 months after the first ever TNFi dispensation. Results: We identified 5003 Crohn's disease patients with TNFi exposure: 3748 surgery naïve and 1255 with bowel surgery prior to TNFi initiation. Of these patients, 7% (n = 353) were subjected to abdominal surgery during the first 12 months after the start of TNFi and were subsequently excluded from the main analysis. A majority (62%) continued TNFi for 12 months or more. Treatment with TNFi for less than 12 months was associated with a significantly higher surgery rate compared with patients who continued on TNFi for 12 months or more (hazard ratio 1.26, 95% CI 1.09–1.46; p = 0.002). Conclusion: Treatment with TNFi for less than 12 months was associated with a higher risk of bowel surgery in Crohn's disease patients compared with those who continued TNFi for 12 months or more.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a biologics
7001 a Myrelid, Päru Linköpings universitet,Linköping University,Division of Surgery, Department of Biomedical and Clinical Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden; Department of Surgery, University Hospital, Linköping, Sweden,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US4 aut0 (Swepub:liu)parmy24
7001 a Söderling, Jonas K.u Karolinska Institutet,Karolinska Institute,Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut
7001 a Ekbom, Andersu Karolinska Institutet,Karolinska Institute,Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut
7001 a Everhov, Åsa H.u Karolinska Institutet,Karolinska Institute,Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden; Karolinska Inst, Sweden4 aut
7001 a Hedin, Charlotte R.H.u Karolinska Institutet,Karolinska Institute,Department of Medicine Solna, Karolinska Institutet, Stockholm, Swede; Division of Gastroenterology, Medical Unit Gastroenterology, Dermatovenereology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden4 aut
7001 a Neovius, Martinu Karolinska Institutet,Karolinska Institute,Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut
7001 a Ludvigsson, Jonas F.,d 1969-u Karolinska Institutet,Örebro universitet,Karolinska Institute,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA,Örebro University Hospital,Institutionen för medicinska vetenskaper,Region Örebro län,Karolinska Inst, Sweden; Orebro Univ Hosp, Sweden; Univ Nottingham, England; Columbia Univ Coll Phys & Surg, NY USA4 aut0 (Swepub:oru)jsln
7001 a Olén, Olau Karolinska Institutet,Karolinska Institute,Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden; Karolinska Inst, Sweden4 aut
7001 a Strid, Hans4 cre
7001 a Hjortswang, Henrik4 cre
7001 a Olsson, Malin4 cre
7001 a Björk, Jan4 cre
7001 a Bengtsson, Jonas L.4 cre
7001 a Halfvarson, Jonas4 cre
7001 a Andersson, Marie A.4 cre
7001 a Karling, Pontus4 cre
7001 a Rejler, Martin4 cre
7001 a Jäghult, Susanna4 cre
7001 a Fagerberg, Ulrika L.4 cre
7001 a Grip, Olofu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 cre0 (Swepub:lu)medf-ogr
7001 a Nordenvall, Caroline4 cre
7102 a Linköping Universityb Karolinska Institute4 org
7102 a SWIBREG Study Group
7730 t Colorectal Diseased : Wileyg 24:4, s. 470-483q 24:4<470-483x 1462-8910x 1463-1318
8564 u http://dx.doi.org/10.1111/codi.16021x freey FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/codi.16021
8564 u https://doi.org/10.1111/codi.16021y Fulltext
8564 u https://liu.diva-portal.org/smash/get/diva2:1636618/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://lup.lub.lu.se/record/adef9445-08f0-4d3e-a5cc-b897f3105e60
8564 8u https://doi.org/10.1111/codi.16021
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-97265
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-182749
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:148603714

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy