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Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study.
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- Winblad, Bengt (author)
- Karolinska Institutet
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- Andreasen, Niels (author)
- Karolinska Institutet
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- Minthon, Lennart (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Floesser, Annette (author)
- Imbert, Georges (author)
- Dumortier, Thomas (author)
- Maguire, R Paul (author)
- Lundmark, Joens (author)
- Staufenbiel, Matthias (author)
- Orgogozo, Jean-Marc (author)
- Graf, Ana (author)
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- (creator_code:org_t)
- 2012
- 2012
- English.
- In: Lancet neurology. - 1474-4465. ; 11:7, s. 597-604
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Immunotherapy targeting the amyloid β (Aβ) peptide is a potential strategy to slow the progression of Alzheimer's disease. We aimed to assess the safety and tolerability of CAD106, a novel active Aβ immunotherapy for patients with Alzheimer's disease, designed to induce N-terminal Aβ-specific antibodies without an Aβ-specific T-cell response.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Aged
- Aged
- 80 and over
- Alzheimer Disease
- blood
- drug therapy
- immunology
- Amyloid beta-Peptides
- immunology
- Antibody Formation
- drug effects
- Biological Markers
- blood
- Double-Blind Method
- Female
- Humans
- Immunoglobulin G
- blood
- Immunotherapy
- Male
- Middle Aged
- Treatment Outcome
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Winblad, Bengt
- Andreasen, Niels
- Minthon, Lennart
- Floesser, Annett ...
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- Dumortier, Thoma ...
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- Maguire, R Paul
- Blennow, Kaj, 19 ...
- Lundmark, Joens
- Staufenbiel, Mat ...
- Orgogozo, Jean-M ...
- Graf, Ana
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
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- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Neurology
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- Lancet neurology
- By the university
- University of Gothenburg
- Karolinska Institutet
- Lund University
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