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Lack of Association...
Lack of Association between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts
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- Maple-Grødem, Jodi (författare)
- The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway
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- Paul, Kimberly C. (författare)
- Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States
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- Dalen, Ingvild (författare)
- Department of Research, Section of Biostatistics, Stavanger University Hospital, Stavanger, Norway
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- Ngo, Kathie J. (författare)
- Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States
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- Wong, Darice (författare)
- Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States; Clinical Neurogenomics Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA, Los Angeles, United States
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- Macleod, Angus D. (författare)
- Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
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- Counsell, Carl E. (författare)
- Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
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- Bäckström, David C, M.D. 1978- (författare)
- Umeå universitet,Neurovetenskaper,Department of Neurology, And Department of Neuroscience, Yale University School of Medicine, CT, New Haven, United States
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- Forsgren, Lars (författare)
- Umeå universitet,Neurovetenskaper
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- Tysnes, Ole-Bjørn (författare)
- Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway
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- Kusters, Cynthia D.J. (författare)
- Department of Human Genetics, University of California Los Angeles, CA, Los Angeles, United States
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- Fogel, Brent L. (författare)
- Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States; Clinical Neurogenomics Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA, Los Angeles, United States
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- Bronstein, Jeff M. (författare)
- Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States
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- Ritz, Beate (författare)
- Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States; Department of Epidemiology, UCLA Fielding School of Public Health, CA, Los Angeles, United States; Department of Biostatistics, UCLA Fielding School of Public Health, CA, Los Angeles, United States
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- Alves, Guido (författare)
- The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway; Department of Neurology, Stavanger University Hospital, Stavanger, Norway
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(creator_code:org_t)
- IOS Press, 2021
- 2021
- Engelska.
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Ingår i: Journal of Parkinson's Disease. - : IOS Press. - 1877-7171 .- 1877-718X. ; 11:4, s. 1569-1578
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson's disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on lacking whether patients with GBA-associated PD differ in their risk of developing motor complications compared to the general PD population.Objective: To evaluate the association of GBA carrier status with the development of LIDS and MFs from early PD.Methods: Motor complications were recorded prospectively in 884 patients with PD from four longitudinal cohorts using part IV of the UPDRS or MDS-UPDRS. Subjects were followed for up to 11 years and the associations of GBA mutations with the development of motor complications were assessed using parametric accelerated failure time models.Results: In 439 patients from Europe, GBA mutations were detected in 53 (12.1%) patients and a total of 168 cases of LIDs and 258 cases of MF were observed. GBA carrier status was not associated with the time to develop LIDs (HR 0.78, 95%CI 0.47 to 1.26, p = 0.30) or MF (HR 1.19, 95%CI 0.84 to 1.70, p = 0.33). In the American cohorts, GBA mutations were detected in 36 (8.1%) patients and GBA carrier status was also not associated with the progression to LIDs (HR 1.08, 95%CI 0.55 to 2.14, p = 0.82) or MF (HR 1.22, 95%CI 0.74 to 2.04, p = 0.43).Conclusion: This study does not provide evidence that GBA-carrier status is associated with a higher risk of developing motor complications. Publication of studies with null results is vital to develop an accurate summary of the clinical features that impact patients with GBA-associated PD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- dyskinesias
- GBA
- motor complications
- motor fluctuations
- Parkinson's disease
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- ref (ämneskategori)
- art (ämneskategori)
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Maple-Grødem, Jo ...
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Paul, Kimberly C ...
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Dalen, Ingvild
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Ngo, Kathie J.
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Wong, Darice
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Macleod, Angus D ...
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Counsell, Carl E ...
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Bäckström, David ...
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Forsgren, Lars
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Tysnes, Ole-Bjør ...
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Kusters, Cynthia ...
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Fogel, Brent L.
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Bronstein, Jeff ...
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Ritz, Beate
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Alves, Guido
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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Journal of Parki ...
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