Sökning: WFRF:(Mallick Himel) > Multi-omics of the ...
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000 | 05283naa a2200973 4500 | |
001 | oai:DiVA.org:umu-160609 | |
003 | SwePub | |
008 | 190624s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1606092 URI |
024 | 7 | a https://doi.org/10.1038/s41586-019-1237-92 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lloyd-Price, Jason4 aut |
245 | 1 0 | a Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases |
264 | c 2019-05-29 | |
264 | 1 | b Nature Publishing Group,c 2019 |
338 | a print2 rdacarrier | |
520 | a Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect several million individuals worldwide. Crohn's disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular, genetic, and microbial levels. Individual contributing factors have been the focus of extensive research. As part of the Integrative Human Microbiome Project (HMP2 or iHMP), we followed 132 subjects for one year each to generate integrated longitudinal molecular profiles of host and microbial activity during disease (up to 24 time points each; in total 2,965 stool, biopsy, and blood specimens). Here we present the results, which provide a comprehensive view of functional dysbiosis in the gut microbiome during inflammatory bowel disease activity. We demonstrate a characteristic increase in facultative anaerobes at the expense of obligate anaerobes, as well as molecular disruptions in microbial transcription (for example, among clostridia), metabolite pools (acylcarnitines, bile acids, and short-chain fatty acids), and levels of antibodies in host serum. Periods of disease activity were also marked by increases in temporal variability, with characteristic taxonomic, functional, and biochemical shifts. Finally, integrative analysis identified microbial, biochemical, and host factors central to this dysregulation. The study's infrastructure resources, results, and data, which are available through the Inflammatory Bowel Disease Multi'omics Database (http://ibdmdb.org), provide the most comprehensive description to date of host and microbial activities in inflammatory bowel diseases. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
700 | 1 | a Arze, Cesar4 aut |
700 | 1 | a Ananthakrishnan, Ashwin N.4 aut |
700 | 1 | a Schirmer, Melanie4 aut |
700 | 1 | a Avila-Pacheco, Julian4 aut |
700 | 1 | a Poon, Tiffany W.4 aut |
700 | 1 | a Andrews, Elizabeth4 aut |
700 | 1 | a Ajami, Nadim J.4 aut |
700 | 1 | a Bonham, Kevin S.4 aut |
700 | 1 | a Brislawn, Colin J.4 aut |
700 | 1 | a Casero, David4 aut |
700 | 1 | a Courtney, Holly4 aut |
700 | 1 | a Gonzalez, Antonio4 aut |
700 | 1 | a Graeber, Thomas G.4 aut |
700 | 1 | a Hall, A. Brantley4 aut |
700 | 1 | a Lake, Kathleen4 aut |
700 | 1 | a Landers, Carol J.4 aut |
700 | 1 | a Mallick, Himel4 aut |
700 | 1 | a Plichta, Damian R.4 aut |
700 | 1 | a Prasad, Mahadev4 aut |
700 | 1 | a Rahnavard, Gholamali4 aut |
700 | 1 | a Sauk, Jenny4 aut |
700 | 1 | a Shungin, Dmitryu Umeå universitet,Institutionen för odontologi,Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA4 aut0 (Swepub:umu)dmsh0003 |
700 | 1 | a Vazquez-Baeza, Yoshiki4 aut |
700 | 1 | a White, Richard A., III4 aut |
700 | 1 | a Braun, Jonathan4 aut |
700 | 1 | a Denson, Lee A.4 aut |
700 | 1 | a Jansson, Janet K.4 aut |
700 | 1 | a Knight, Rob4 aut |
700 | 1 | a Kugathasan, Subra4 aut |
700 | 1 | a McGovern, Dermot P. B.4 aut |
700 | 1 | a Petrosino, Joseph F.4 aut |
700 | 1 | a Stappenbeck, Thaddeus S.4 aut |
700 | 1 | a Winter, Harland S.4 aut |
700 | 1 | a Clish, Clary B.4 aut |
700 | 1 | a Franzosa, Eric A.4 aut |
700 | 1 | a Vlamakis, Hera4 aut |
700 | 1 | a Xavier, Ramnik J.4 aut |
700 | 1 | a Huttenhower, Curtis4 aut |
700 | 1 | a Bishai, Jason4 aut |
700 | 1 | a Bullock, Kevin4 aut |
700 | 1 | a Deik, Amy4 aut |
700 | 1 | a Dennis, Courtney4 aut |
700 | 1 | a Kaplan, Jess L.4 aut |
700 | 1 | a Khalili, Hamed4 aut |
700 | 1 | a McIver, Lauren J.4 aut |
700 | 1 | a Moran, Christopher J.4 aut |
700 | 1 | a Nguyen, Long4 aut |
700 | 1 | a Pierce, Kerry A.4 aut |
700 | 1 | a Schwager, Randall4 aut |
700 | 1 | a Sirota-Madi, Alexandra4 aut |
700 | 1 | a Stevens, Betsy W.4 aut |
700 | 1 | a Tan, William4 aut |
700 | 1 | a ten Hoeve, Johanna J.4 aut |
700 | 1 | a Weingart, George4 aut |
700 | 1 | a Wilson, Robin G.4 aut |
700 | 1 | a Yajnik, Vijay4 aut |
710 | 2 | a Umeå universitetb Institutionen för odontologi4 org |
773 | 0 | t Natured : Nature Publishing Groupg 569:7758, s. 655-661q 569:7758<655-661x 0028-0836x 1476-4687 |
856 | 4 | u https://www.nature.com/articles/s41586-019-1237-9.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-160609 |
856 | 4 8 | u https://doi.org/10.1038/s41586-019-1237-9 |
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