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Sökning: WFRF:(Manan L) > (2017) > Single and multiple...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004761naa a2200421 4500
001oai:lup.lub.lu.se:22b2a23d-52e6-4913-99bc-702342c29468
003SwePub
008170831s2017 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/22b2a23d-52e6-4913-99bc-702342c294682 URI
0247 a https://doi.org/10.1177/20474873177170652 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Pareek, Mananu Odense University Hospital4 aut
2451 0a Single and multiple cardiovascular biomarkers in subjects without a previous cardiovascular event
264 c 2017-06-23
264 1b Oxford University Press (OUP),c 2017
520 a Aims To assess the incremental value of biomarkers, including N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), growth differentiation factor 15 (GDF-15), and procollagen type 1 N-terminal propeptide (P1NP), in predicting incident cardiovascular events and mortality among asymptomatic individuals from the general population, beyond traditional risk factors, including fasting glucose and renal function (cystatin C), medication use, and echocardiographic measures. Methods and results Prospective population-based cohort study of 1324 subjects without a previous cardiovascular event, who underwent baseline echocardiography and biomarker assessment between 2002 and 2006. The clinical endpoint was the composite of myocardial infarction, invasively treated stable/unstable ischemic heart disease, heart failure, stroke, or all-cause mortality. Predictive capabilities were evaluated using Cox proportional-hazards regression, Harrell's concordance index (C-index), and net reclassification improvement. Median age was 66 (interquartile range: 60-70) years, and 413 (31%) were female. During median 8.6 (interquartile range: 8.1-9.2) follow-up years, 368 (28%) composite events occurred. NT-proBNP, hs-TnT, GDF-15, and IL-6 were significantly associated with outcome, independently of traditional risk factors, medications, and echocardiography ( p < 0.05 for all). Separate addition of NT-proBNP and GDF-15 to traditional risk factors, medications, and echocardiographic measurements provided significant improvements in discriminative ability (NT-proBNP: C-index 0.714 vs. 0.703, p = 0.03; GDF-15: C-index 0.721 vs. 0.703, p = 0.02). Both biomarkers remained significant predictors of outcome upon inclusion in the same model ( p < 0.05 for both). Conclusions NT-proBNP and GDF-15 each enhance prognostication beyond traditional risk factors, glucose levels, renal function, and echocardiography in individuals without known cardiovascular disease.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Bhatt, Deepak Lu Harvard Medical School4 aut
7001 a Vaduganathan, Muthiahu Harvard Medical School4 aut
7001 a Biering-Sørensen, Toru University of Copenhagen4 aut
7001 a Qamar, Armanu Harvard Medical School4 aut
7001 a Diederichsen, Axel Cpu Odense University Hospital4 aut
7001 a Møller, Jacob Eiferu Odense University Hospital4 aut
7001 a Hindersson, Peteru Aalborg University Hospital4 aut
7001 a Leosdottir, Margrétu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-mle
7001 a Magnusson, Martinu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-mma
7001 a Nilsson, Peter Mu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-pni
7001 a Olsen, Michael H.u Holbæk Hospital4 aut
7102 a Odense University Hospitalb Harvard Medical School4 org
7730 t European Journal of Preventive Cardiologyd : Oxford University Press (OUP)g , s. 1648-1659q <1648-1659x 2047-4881x 2047-4873
8564 u http://dx.doi.org/10.1177/2047487317717065y FULLTEXT
8564 8u https://lup.lub.lu.se/record/22b2a23d-52e6-4913-99bc-702342c29468
8564 8u https://doi.org/10.1177/2047487317717065

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