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FältnamnIndikatorerMetadata
00004082naa a2200397 4500
001oai:lup.lub.lu.se:c425b721-e539-4e88-8475-dd9c4af51632
003SwePub
008180122s2018 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/c425b721-e539-4e88-8475-dd9c4af516322 URI
0247 a https://doi.org/10.2337/dc17-13512 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Pareek, Mananu Odense University Hospital,Brigham and Women's Hospital / Harvard Medical School4 aut
2451 0a Enhanced predictive capability of a 1-hour oral glucose tolerance test : A prospective population-based cohort study
264 c 2017-11-14
264 1b American Diabetes Association,c 2018
300 a 7 s.
520 a OBJECTIVE To examine whether the 1-h blood glucose measurement would be a more suitable screening tool for assessing the risk of diabetes and its complications than the 2-h measurement. RESEARCH DESIGN AND METHODS We conducted a prospective population-based cohort study of 4,867men, randomly selected fromprespecified birth cohorts between 1921 and 1949,who underwent an oral glucose tolerance test with blood glucose measurements at 0, 1, and 2 h. Subjects were followed for up to 39 years, with registry-based recording of events. Discriminative abilities of elevated 1-h (≥8.6 mmol/L) versus 2-h (≥7.8 mmol/L) glucose for predicting incident type 2 diabetes, vascular complications, andmortality were compared using Kaplan-Meier analysis, Cox proportional hazards regression, and net reclassification improvement. RESULTS Median agewas 48 years (interquartile range [IQR] 48-49). During follow-up (median 33 years [IQR 24-37]), 636 (13%) developed type 2 diabetes. Elevated 1-h glucose was associatedwith incident diabetes (hazard ratio 3.40 [95% CI 2.90-3.98], P < 0.001) and provided better risk assessment than impaired glucose tolerance (Harrell concordance index 0.637 vs. 0.511, P < 0.001). Addition of a 1-hmeasurement in subjects stratified by fasting glucose provided greater net reclassification improvement than the addition of a 2-h measurement (0.214 vs. 0.016, respectively). Finally, the 1-h glucose was significantly associated with vascular complications and mortality. CONCLUSIONS The 1-h blood glucose level is a stronger predictor of future type 2 diabetes than the 2-h level and is associated with diabetes complications and mortality.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Bhatt, Deepak L.u Brigham and Women's Hospital / Harvard Medical School4 aut
7001 a Nielsen, Mette L.u Odense University Hospital4 aut
7001 a Jagannathan, Ramu New York University4 aut
7001 a Eriksson, Karl Fredriku Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-ker
7001 a Nilsson, Peter M.u Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-pni
7001 a Bergman, Michaelu New York University4 aut
7001 a Olsen, Michael H.u Odense University Hospital4 aut
7102 a Odense University Hospitalb Brigham and Women's Hospital / Harvard Medical School4 org
7730 t Diabetes Cared : American Diabetes Associationg 41:1, s. 171-177q 41:1<171-177x 0149-5992x 1935-5548
8564 u http://dx.doi.org/10.2337/dc17-1351y FULLTEXT
8564 u https://care.diabetesjournals.org/content/diacare/41/1/171.full.pdf
8564 8u https://lup.lub.lu.se/record/c425b721-e539-4e88-8475-dd9c4af51632
8564 8u https://doi.org/10.2337/dc17-1351

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