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Adolescents with ob...
Adolescents with obesity treated with exenatide maintain endogenous GLP-1, reduce DPP-4, and improve glycemic control
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- Stenlid, Rasmus (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för kvinnors och barns hälsa,Uppsala Univ, Childrens Hosp, Dept Pediat Obes, Uppsala, Sweden.
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- Cerenius, Sara Y. (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Wen, Quan (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Aydin, Banu K. (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Institutionen för medicinsk cellbiologi
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- Manell, Hannes (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Childrens Hosp, Dept Pediat Obes, Uppsala, Sweden.
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- Chowdhury, Azazul Islam (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Kristinsson, Hjalti (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Ciba, Iris (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Childrens Hosp, Dept Pediat Obes, Uppsala, Sweden.
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- Gjessing, Erik S. (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Moerwald, Katharina (author)
- Paracelsus Med Univ, Dept Pediat, Salzburg, Austria.;Paracelsus Med Univ, Obes Res Unit, Salzburg, Austria.
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- Gomahr, Julian (author)
- Paracelsus Med Univ, Dept Pediat, Salzburg, Austria.;Paracelsus Med Univ, Obes Res Unit, Salzburg, Austria.
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- Heu, Verena (author)
- Paracelsus Med Univ, Dept Pediat, Salzburg, Austria.;Paracelsus Med Univ, Obes Res Unit, Salzburg, Austria.
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- Weghuber, Daniel (author)
- Paracelsus Med Univ, Dept Pediat, Salzburg, Austria.;Paracelsus Med Univ, Obes Res Unit, Salzburg, Austria.
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- Forslund, Anders, 1961- (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Childrens Hosp, Dept Pediat Obes, Uppsala, Sweden.
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- Bergsten, Peter (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Childrens Hosp, Dept Pediat Obes, Uppsala, Sweden.
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(creator_code:org_t)
- Frontiers Media S.A. 2023
- 2023
- English.
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In: Frontiers in Endocrinology. - : Frontiers Media S.A.. - 1664-2392. ; 14
- Related links:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Background: GLP-1 receptor agonists (GLP-1RA) are increasingly used to treat adolescent obesity. However, the effect on endogenous GLP-1 secretory patterns following treatment in adolescents is unknown. The GLP-1RA exenatide was shown to significantly lower BMI and 2-hour glucose in adolescents with obesity, in the placebo-controlled, randomized controlled trial Combat-JUDO. The aim of this study was to evaluate effects of weekly injections of 2 mg exenatide extended release on secretory patterns of endogenous hormones during OGTT.Subjects and Measurements: This study was a pre-planned sub-study of the Combat-JUDO trial, set at the Pediatric clinic at Uppsala University Hospital, Sweden and Paracelsus Medical University, Austria. 44 adolescents with obesity were included and randomized 1:1 to treatment:placebo. 19 patients in the treatment group and 18 in the placebo group completed the trial. Before and after treatment, GLP-1, glucose, insulin, glucagon and glicentin levels were measured during OGTT; DPP-4 and proinsulin were measured at fasting. A per-protocol approach was used in the analyses.Results: Exenatide treatment did not affect GLP-1 levels during OGTT. Treatment significantly lowered DPP-4, proinsulin and the proinsulin-to-insulin ratio at fasting, increased glicentin levels but did not affect insulin, C-peptide or glucagon levels during OGTT.Conclusion: Weekly s.c. injections with 2 mg of exenatide maintains endogenous total GLP-1 levels and lowers circulating DPP-4 levels. This adds an argument in favor of using exenatide in the treatment of pediatric obesity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- obesity
- GLP-1
- GLP-1 receptor analog
- exenatide
- pediatrics
- glycemic control
- GLP-1 receptor agonist
- treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Stenlid, Rasmus
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Cerenius, Sara Y ...
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Wen, Quan
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Aydin, Banu K.
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Manell, Hannes
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Chowdhury, Azazu ...
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Kristinsson, Hja ...
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Ciba, Iris
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Gjessing, Erik S ...
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Moerwald, Kathar ...
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Gomahr, Julian
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Heu, Verena
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Weghuber, Daniel
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Forslund, Anders ...
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Bergsten, Peter
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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