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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008462naa a2200937 4500
001oai:DiVA.org:uu-497477
003SwePub
008230301s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4974772 URI
0247 a https://doi.org/10.1111/febs.161422 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lüscher, Bernhardu Rhein Westfal TH Aachen, Inst Biochem & Mol Biol, Aachen, Germany.4 aut
2451 0a ADP-ribosyltransferases, an update on function and nomenclature
264 c 2021-09-13
264 1b John Wiley & Sons,c 2022
338 a electronic2 rdacarrier
520 a ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for example, by DNA damage and viral infection and is involved in intra- and extracellular signaling, chromatin and transcriptional regulation, protein biosynthesis, and cell death. ADP-ribosylation is catalyzed by ADP-ribosyltransferases (ARTs), which transfer ADP-ribose from NAD+ onto substrates. The modification, which occurs as mono- or poly-ADP-ribosylation, is reversible due to the action of different ADP-ribosylhydrolases. Importantly, inhibitors of ARTs are approved or are being developed for clinical use. Moreover, ADP-ribosylhydrolases are being assessed as therapeutic targets, foremost as antiviral drugs and for oncological indications. Due to the development of novel reagents and major technological advances that allow the study of ADP-ribosylation in unprecedented detail, an increasing number of cellular processes and pathways are being identified that are regulated by ADP-ribosylation. In addition, characterization of biochemical and structural aspects of the ARTs and their catalytic activities have expanded our understanding of this protein family. This increased knowledge requires that a common nomenclature be used to describe the relevant enzymes. Therefore, in this viewpoint, we propose an updated and broadly supported nomenclature for mammalian ARTs that will facilitate future discussions when addressing the biochemistry and biology of ADP-ribosylation. This is combined with a brief description of the main functions of mammalian ARTs to illustrate the increasing diversity of mono- and poly-ADP-ribose mediated cellular processes.
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
653 a ADP-ribosylation
653 a MARylation
653 a PARP
653 a PARylation
653 a posttranslational modification
7001 a Ahel, Ivanu Univ Oxford, Sir William Dunn Sch Pathol, Oxford, England.4 aut
7001 a Altmeyer, Matthiasu Univ Zurich, Dept Mol Mech Dis, Zurich, Switzerland.4 aut
7001 a Ashworth, Alanu UCSF Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA.4 aut
7001 a Bai, Peteru Univ Debrecen, Fac Med, Dept Med Chem, Debrecen, Hungary.4 aut
7001 a Chang, Paulu ARase Therapeut, Cambridge, MA USA.4 aut
7001 a Cohen, Michaelu Oregon Hlth & Sci Univ, Dept Chem Physiol & Biochem, Portland, OR 97201 USA.4 aut
7001 a Corda, Danielau CNR, Dept Biomed Sci, Rome, Italy.4 aut
7001 a Dantzer, Francoiseu CNRS, BSC UMR7242, Illkirch Graffenstaden, France.4 aut
7001 a Daugherty, Matthew D.u Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA.4 aut
7001 a Dawson, Ted M.u Johns Hopkins Univ, Neuroregenerat & Stem Cell Programs, Inst Cell Engn, Sch Med, Baltimore, MD USA.4 aut
7001 a Dawson, Valina L.u Johns Hopkins Univ, Neuroregenerat & Stem Cell Programs, Inst Cell Engn, Sch Med, Baltimore, MD USA.4 aut
7001 a Deindl, Sebastianu Uppsala universitet,Molekylär systembiologi4 aut0 (Swepub:uu)sebde386
7001 a Fehr, Anthony R.u Univ Kansas, Dept Mol Biosci, Lawrence, KS 66045 USA.4 aut
7001 a Feijs, Karla L. H.u Rhein Westfal TH Aachen, Inst Biochem & Mol Biol, Aachen, Germany.4 aut
7001 a Filippov, Dmitri V.u Leiden Univ, Leiden Inst Chem, Leiden, Netherlands.4 aut
7001 a Gagné, Jean-Philippeu Laval Univ, Dept Mol Biol Med Biochem & Pathol, Fac Med, Quebec City, PQ, Canada.4 aut
7001 a Grimaldi, Giovannau CNR, Naples, Italy.4 aut
7001 a Guettler, Sebastianu Inst Canc Res ICR, Div Struct Biol, London, England.;Inst Canc Res ICR, Div Canc Biol, London, England.4 aut
7001 a Hoch, Nicolas C.u Univ Sao Paulo, Dept Biochem, Sao Paulo, Brazil.4 aut
7001 a Hottiger, Michael O.u Univ Zurich, Dept Mol Mech Dis, Zurich, Switzerland.4 aut
7001 a Korn, Patriciau Rhein Westfal TH Aachen, Inst Biochem & Mol Biol, Aachen, Germany.4 aut
7001 a Kraus, W. Leeu Univ Texas Southwestern Med Ctr, Cecil H & Ida Green Ctr Reprod Biol Sci, Dallas, TX USA.4 aut
7001 a Ladurner, Andreasu Ludwig Maximilians Univ Munchen, Dept Physiol Chem, Planegg Martinsried, Germany.4 aut
7001 a Lehtiö, Lariu Univ Oulu, Fac Biochem & Mol Med, Oulu, Finland.;Bioctr Oulu, Oulu, Finland.4 aut
7001 a Leung, Anthony K. L.u Johns Hopkins Univ, Dept Biochem & Mol Biol, Bloomberg Sch Publ Hlth, Baltimore, MD USA.4 aut
7001 a Lord, Christopher J.u Inst Canc Res, Breast Canc Now Toby Robins Res Ctr, CRUK Gene Funct Lab, London, England.4 aut
7001 a Mangerich, Aswinu Univ Konstanz, Dept Biol, Constance, Germany.4 aut
7001 a Matic, Ivanu Max Planck Inst Biol Ageing, Cologne, Germany.;Univ Cologne, Cologne Excellence Cluster Stress Responses Agein, Cologne, Germany.4 aut
7001 a Matthews, Jasonu Univ Oslo, Inst Basic Med Sci, Oslo, Norway.4 aut
7001 a Moldovan, George-Lucianu Penn State Univ, Dept Biochem & Mol Biol, Coll Med, Hershey, PA USA.4 aut
7001 a Moss, Joelu NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA.4 aut
7001 a Natoli, Gioacchinou European Inst Oncol IEO, Dept Expt Oncol, Milan, Italy.4 aut
7001 a Nielsen, Michael L.u Univ Copenhagen, Novo Nordisk Fdn, Fac Hlth & Med Sci, Prote Program,Ctr Prot Res, Copenhagen, Denmark.4 aut
7001 a Niepel, Mariou Ribon Therapeut, Cambridge, MA USA.4 aut
7001 a Nolte, Friedrichu Univ Klinikum Hamburg Eppendorf, Inst Immunol, Hamburg, Germany.4 aut
7001 a Pascal, Johnu Univ Montreal, Biochem & Mol Med, Montreal, PQ, Canada.4 aut
7001 a Paschal, Bryce M.u Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA USA.4 aut
7001 a Pawlowski, Krzysztofu Univ Texas Southwestern Med Ctr, Dept Mol Biol, Dallas, TX USA.4 aut
7001 a Poirier, Guy G.u Laval Univ, Dept Mol Biol Med Biochem & Pathol, Fac Med, Quebec City, PQ, Canada.4 aut
7001 a Smith, Susanu Univ Zurich, Dept Mol Mech Dis, Zurich, Switzerland.;NYU, Kimmel Ctr Biol & Med, Dept Pathol, Skirball Inst,Sch Med, New York, NY 10003 USA.4 aut
7001 a Timinszky, Gyulau Eotvos Lorand Res Network ELKH, Lendulet Lab DNA Damage & Nucl Dynam, Inst Genet, Biol Res Ctr, Szeged, Hungary.4 aut
7001 a Wang, Zhao-Qiu Leibniz Inst Aging, Fritz Lipmann Inst FLI, Jena, Germany.;Friedrich Schiller Univ Jena, Fac Biol Sci, Jena, Germany.4 aut
7001 a Yelamos, Joseu Hosp del Mar Med Res Inst IMIM, Canc Res Program, Barcelona, Spain.4 aut
7001 a Yu, Xiaochunu Westlake Univ, Sch Life Sci, Hangzhou, Peoples R China.4 aut
7001 a Zaja, Rokou Rhein Westfal TH Aachen, Inst Biochem & Mol Biol, Aachen, Germany.4 aut
7001 a Ziegler, Mathiasu Univ Bergen, Dept Biomed, Bergen, Norway.4 aut
7102 a Rhein Westfal TH Aachen, Inst Biochem & Mol Biol, Aachen, Germany.b Univ Oxford, Sir William Dunn Sch Pathol, Oxford, England.4 org
7730 t The FEBS Journald : John Wiley & Sonsg 289:23, s. 7399-7410q 289:23<7399-7410x 1742-464Xx 1742-4658
8564 u https://doi.org/10.1111/febs.16142y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1740444/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.16142
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-497477
8564 8u https://doi.org/10.1111/febs.16142

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