Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe

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Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe

Fidler, Miranda M. (author): University of Birmingham

Reulen, Raoul C. (author): University of Birmingham

Winter, David L. (author): University of Birmingham

Allodji, Rodrigue S. (author): National Institute for Health and Medical Research, France

Bagnasco, Francesca (author): Gaslini Children's Hospital

Bárdi, Edit (author): Semmelweis University,Kepler University Hospital Linz

Bautz, Andrea (author): Danish Cancer Society

Bright, Chloe J. (author): University of Birmingham

Byrne, Julianne (author): Boyne Research Institute

Feijen, Elizabeth A M (author): Emma Children’s Hospital

Garwicz, Stanislaw (author): Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine

Grabow, Desiree (author)

Gudmundsdottir, Thorgerdur (author)

Guha, Joyeeta (author): University of Birmingham

Haddy, Nadia (author)

Jankovic, Momcilo (author)

Kaatsch, Peter (author)

Kaiser, Melanie (author)

Kuonen, Rahel (author)

Linge, Helena (author): Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine

Maule, Milena (author)

Merletti, Franco (author)

Øfstaas, Hilde (author)

Ronckers, Cecile M. (author)

Skinner, Roderick (author)

Teepen, Jop (author)

Terenziani, Monica (author)

Vu-Bezin, Giao (author)

Wesenberg, Finn (author)

Wiebe, Thomas (author): Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine

Jakab, Zsuzsanna (author)

Haupt, Riccardo (author)

Lähteenmäki, Päivi M (author)

Zaletel, Lorna Zadravec (author)

Kuehni, Claudia E. (author)

Winther, Jeanette F (author)

De Vathaire, Florent (author)

Kremer, Leontien C. M. (author)

Hjorth, Lars (author): Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine

Hawkins, Michael M. (author)

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(creator_code:org_t)

2017-09-26
2018
English.
In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 1460-2105 .- 0027-8874. ; 110:2

Related links:: http://dx.doi.org/10... (free); show more...; https://academic.oup...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Introduction: We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For the first time, we satisfactorily address the risks beyond 40 years from diagnosis and beyond 40 years of age among all survivors.Methods: This largest-ever assembled cohort comprises 69 460 five-year survivors of cancer diagnosed before age 20 years. Standardized incidence ratios, absolute excess risks, and multivariable-adjusted relative risks and relative excess risks were calculated. All statistical tests were two-sided.Results: Overall, survivors were 21.65 times (95% confidence interval = 18.97 to 24.60 times) more likely to be diagnosed with a subsequent primary bone cancer than expected from the general population. The greatest excess numbers of bone cancers were observed after retinoblastoma, bone sarcoma, and soft tissue sarcoma. The excess number of bone cancers declined linearly with both years since diagnosis and attained age (all P < .05). Beyond 40 years from diagnosis and age 40 years, there were at most 0.45 excess bone cancers among all survivors per 10 000 person-years at risk; beyond 30 years from diagnosis and age 30 years, there were at most 5.02 excess bone cancers after each of retinoblastoma, bone sarcoma, and soft tissue sarcoma, per 10 000 person-years at risk.Conclusions: For all survivors combined and the cancer groups with the greatest excess number of bone cancers, the excess numbers observed declined with both age and years from diagnosis. These results provide novel, reliable, and unbiased information about risks and risk factors among long-term survivors of childhood and adolescent cancer.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

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