Search: WFRF:(McBride D)
> (2020-2023) >
Immunomodulatory Mi...
Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis
-
McBride, D. A. (author)
-
Kerr, M. D. (author)
-
Johnson, W. T. (author)
-
show more...
-
- Nguyen, Anders, 1995 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
-
Zoccheddu, M. (author)
-
Yao, M. N. (author)
-
Prideaux, E. B. (author)
-
Dorn, N. C. (author)
-
Wang, W. (author)
-
- Svensson, Mattias N D (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
-
Bottini, N. (author)
-
Shah, N. J. (author)
-
show less...
-
(creator_code:org_t)
- 2023-03-08
- 2023
- English.
-
In: Advanced Science. - : Wiley. - 2198-3844. ; 10:11
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Disease modifying antirheumatic drugs (DMARDs) have improved the prognosis of autoimmune inflammatory arthritides but a large fraction of patients display partial or nonresponsiveness to front-line DMARDs. Here, an immunoregulatory approach based on sustained joint-localized release of all-trans retinoic acid (ATRA), which modulates local immune activation and enhances disease-protective T cells and leads to systemic disease control is reported. ATRA imprints a unique chromatin landscape in T cells, which is associated with an enhancement in the differentiation of naive T cells into anti-inflammatory regulatory T cells (T-reg) and suppression of T-reg destabilization. Sustained release poly-(lactic-co-glycolic) acid (PLGA)-based biodegradable microparticles encapsulating ATRA (PLGA-ATRA MP) are retained in arthritic mouse joints after intra-articular (IA) injection. IA PLGA-ATRA MP enhance migratory T-reg which in turn reduce inflammation and modify disease in injected and uninjected joints, a phenotype that is also reproduced by IA injection of T-reg. PLGA-ATRA MP reduce proteoglycan loss and bone erosions in the SKG and collagen-induced arthritis mouse models of autoimmune arthritis. Strikingly, systemic disease modulation by PLGA-ATRA MP is not associated with generalized immune suppression. PLGA-ATRA MP have the potential to be developed as a disease modifying agent for autoimmune arthritis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- immune engineering
- regulatory T cells
- rheumatoid arthritis
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
McBride, D. A.
-
Kerr, M. D.
-
Johnson, W. T.
-
Nguyen, Anders, ...
-
Zoccheddu, M.
-
Yao, M. N.
-
show more...
-
Prideaux, E. B.
-
Dorn, N. C.
-
Wang, W.
-
Svensson, Mattia ...
-
Bottini, N.
-
Shah, N. J.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
- Articles in the publication
-
Advanced Science
- By the university
-
University of Gothenburg