WFRF:(Medina Sanchez Jessica Danielly)
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Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation
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- Arasa, Jorge (author)
- Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
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- Collado-Diaz, Victor (author)
- Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
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- Kritikos, Ioannis (author)
- Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.
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- Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland Max Planck Inst Immunobiol & Epigenet, Freiburg, Germany.;Univ Freiburg, Fac Biol, Freiburg, Germany.;Int Max Planck Res Sch Immunobiol Epigenet & Meta, Freiburg, Germany. (creator_code:org_t)
- 2021-05-14
- 2021
- English.
- In: Journal of Experimental Medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 218:7
- Journal article (peer-reviewed)
Abstract
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- Dendritic cell (DC) migration to draining lymph nodes (dLNs) is a slow process that is believed to begin with DCs approaching and entering into afferent lymphatic capillaries. From capillaries, DCs slowly crawl into lymphatic collectors, where lymph flow induced by collector contraction supports DC detachment and thereafter rapid, passive transport to dLNs. Performing a transcriptomics analysis of dermal endothelial cells, we found that inflammation induces the degradation of the basement membrane (BM) surrounding lymphatic collectors and preferential up-regulation of the DC trafficking molecule VCAM-1 in collectors. In crawl-in experiments performed in ear skin explants, DCs entered collectors in a CCR7- and beta 1 integrin-dependent manner. In vivo, loss of beta 1-integrins in DCs or of VCAM-1 in lymphatic collectors had the greatest impact on DC migration to dLNs at early time points when migration kinetics favor the accumulation of rapidly migrating collector DCs rather than slower capillary DCs. Taken together, our findings identify collector entry as a critical mechanism enabling rapid DC migration to dLNs in inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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