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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004739naa a2200493 4500
001oai:DiVA.org:uu-449342
003SwePub
008210723s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4493422 URI
0247 a https://doi.org/10.1084/jem.202014132 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Arasa, Jorgeu Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.4 aut
2451 0a Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation
264 c 2021-05-14
264 1b Rockefeller University Press,c 2021
338 a print2 rdacarrier
520 a Dendritic cell (DC) migration to draining lymph nodes (dLNs) is a slow process that is believed to begin with DCs approaching and entering into afferent lymphatic capillaries. From capillaries, DCs slowly crawl into lymphatic collectors, where lymph flow induced by collector contraction supports DC detachment and thereafter rapid, passive transport to dLNs. Performing a transcriptomics analysis of dermal endothelial cells, we found that inflammation induces the degradation of the basement membrane (BM) surrounding lymphatic collectors and preferential up-regulation of the DC trafficking molecule VCAM-1 in collectors. In crawl-in experiments performed in ear skin explants, DCs entered collectors in a CCR7- and beta 1 integrin-dependent manner. In vivo, loss of beta 1-integrins in DCs or of VCAM-1 in lymphatic collectors had the greatest impact on DC migration to dLNs at early time points when migration kinetics favor the accumulation of rapidly migrating collector DCs rather than slower capillary DCs. Taken together, our findings identify collector entry as a critical mechanism enabling rapid DC migration to dLNs in inflammation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
7001 a Collado-Diaz, Victoru Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.4 aut
7001 a Kritikos, Ioannisu Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.4 aut
7001 a Medina-Sanchez, Jessica Daniellyu Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.4 aut
7001 a Friess, Mona Carinau Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.4 aut
7001 a Sigmund, Elena Carolineu Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.4 aut
7001 a Schineis, Philippu Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.4 aut
7001 a Hunter, Morgan Campbellu Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.4 aut
7001 a Tacconi, Carlottau Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.4 aut
7001 a Paterson, Neilu Max Planck Inst Immunobiol & Epigenet, Freiburg, Germany.;Univ Freiburg, Fac Biol, Freiburg, Germany.;Int Max Planck Res Sch Immunobiol Epigenet & Meta, Freiburg, Germany.4 aut
7001 a Nagasawa, Takashiu Osaka Univ, Grad Sch Frontier Biosci, Lab Stem Cell Biol & Dev Immunol, Osaka, Japan.;Osaka Univ, Grad Sch Med, Osaka, Japan.4 aut
7001 a Kiefer, Friedemannu Max Planck Inst Mol Biomed, Munster, Germany.;Westfalische Wilhelms Univ Munster, European Inst Mol Imaging, Munster, Germany.4 aut
7001 a Mäkinen, Taijau Uppsala universitet,Vaskulärbiologi4 aut0 (Swepub:uu)taima352
7001 a Detmar, Michaelu Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.4 aut
7001 a Moser, Markusu Max Planck Inst Biochem, Martinsried, Germany.;Tech Univ Munich, Inst Expt Hematol, Munich, Germany.4 aut
7001 a Laemmermann, Timu Max Planck Inst Immunobiol & Epigenet, Freiburg, Germany.4 aut
7001 a Halin, Corneliau Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.4 aut
7102 a Swiss Fed Inst Technol, Inst Pharmaceut Sci, Zurich, Switzerland.b Max Planck Inst Immunobiol & Epigenet, Freiburg, Germany.;Univ Freiburg, Fac Biol, Freiburg, Germany.;Int Max Planck Res Sch Immunobiol Epigenet & Meta, Freiburg, Germany.4 org
7730 t Journal of Experimental Medicined : Rockefeller University Pressg 218:7q 218:7x 0022-1007x 1540-9538
8564 u https://doi.org/10.1084/jem.20201413
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-449342
8564 8u https://doi.org/10.1084/jem.20201413

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