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CD4+ T cell-induced...
CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours
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- Kruse, Bastian (author)
- Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Buzzai, Anthony C. (author)
- Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Shridhar, Naveen (author)
- Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Braun, Andreas D. (author)
- Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Gellert, Susan (author)
- Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Knauth, Kristin (author)
- Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Pozniak, Joanna (author)
- VIB, Ctr Canc Biol, Lab Mol Canc Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium.
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- Peters, Johannes (author)
- Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Dittmann, Paulina (author)
- Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Mengoni, Miriam (author)
- Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- van der Sluis, Tetje Cornelia (author)
- Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Höhn, Simon (author)
- Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Antoranz, Asier (author)
- Katholieke Univ Leuven, Dept Imaging & Pathol, Translat Cell & Tissue Res, Leuven, Belgium.
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- Krone, Anna (author)
- Otto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Fu, Yan (author)
- Otto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Yu, Di, 1985- (author)
- Uppsala universitet,Cancerimmunterapi
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- Essand, Magnus (author)
- Uppsala universitet,Cancerimmunterapi
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- Geffers, Robert (author)
- Helmholtz Ctr Infect Res, Braunschweig, Germany.
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- Mougiakakos, Dimitrios (author)
- Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.;Otto von Guericke Univ, Dept Hematol, Univ Hosp, Magdeburg, Germany.
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- Kahlfuss, Sascha (author)
- Otto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Kashkar, Hamid (author)
- Univ Cologne, Inst Mol Immunol, Ctr Mol Med Cologne, Cologne, Germany.;Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany.
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- Gaffal, Evelyn (author)
- Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Bosisio, Francesca M. (author)
- UZ Leuven, Dept Pathol, Leuven, Belgium.
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- Bechter, Oliver (author)
- UZ Leuven, Dept Gen Med Oncol, Leuven, Belgium.
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- Rambow, Florian (author)
- Univ Hosp Essen, Inst Med IKIM, Dept Appl Computat Canc Res, Essen, Germany.;Univ Duisburg Essen, Essen, Germany.
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- Marine, Jean-Christophe (author)
- VIB, Ctr Canc Biol, Lab Mol Canc Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium.
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- Kastenmüller, Wolfgang (author)
- Inst Syst Immunol, Wurzburg, Germany.
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- Müller, Andreas J. (author)
- Otto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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- Tüting, Thomas (author)
- Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. VIB, Ctr Canc Biol, Lab Mol Canc Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium. (creator_code:org_t)
- Springer Nature, 2023
- 2023
- English.
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In: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687. ; 618:7967, s. 1033-1040
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Most clinically applied cancer immunotherapies rely on the ability of CD8+ cytolytic T cells to directly recognize and kill tumour cells1,2,3. These strategies are limited by the emergence of major histocompatibility complex (MHC)-deficient tumour cells and the formation of an immunosuppressive tumour microenvironment4,5,6. The ability of CD4+ effector cells to contribute to antitumour immunity independently of CD8+ T cells is increasingly recognized, but strategies to unleash their full potential remain to be identified7,8,9,10. Here, we describe a mechanism whereby a small number of CD4+ T cells is sufficient to eradicate MHC-deficient tumours that escape direct CD8+ T cell targeting. The CD4+ effector T cells preferentially cluster at tumour invasive margins where they interact with MHC-II+CD11c+ antigen-presenting cells. We show that T helper type 1 cell-directed CD4+ T cells and innate immune stimulation reprogramme the tumour-associated myeloid cell network towards interferon-activated antigen-presenting and iNOS-expressing tumouricidal effector phenotypes. Together, CD4+ T cells and tumouricidal myeloid cells orchestrate the induction of remote inflammatory cell death that indirectly eradicates interferon-unresponsive and MHC-deficient tumours. These results warrant the clinical exploitation of this ability of CD4+ T cells and innate immune stimulators in a strategy to complement the direct cytolytic activity of CD8+ T cells and natural killer cells and advance cancer immunotherapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nature
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- By the author/editor
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Kruse, Bastian
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Buzzai, Anthony ...
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Shridhar, Naveen
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Braun, Andreas D ...
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Gellert, Susan
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Knauth, Kristin
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show more...
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Pozniak, Joanna
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Peters, Johannes
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Dittmann, Paulin ...
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Mengoni, Miriam
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van der Sluis, T ...
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Höhn, Simon
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Antoranz, Asier
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Krone, Anna
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Fu, Yan
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Yu, Di, 1985-
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Essand, Magnus
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Geffers, Robert
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Mougiakakos, Dim ...
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Kahlfuss, Sascha
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Kashkar, Hamid
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Gaffal, Evelyn
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Bosisio, Frances ...
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Bechter, Oliver
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Rambow, Florian
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Marine, Jean-Chr ...
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Kastenmüller, Wo ...
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Müller, Andreas ...
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Tüting, Thomas
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
- Articles in the publication
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Nature
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Uppsala University