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Sökning: WFRF:(Merritt Melissa A) > (2014) > Insulin-like growth...

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FältnamnIndikatorerMetadata
00005446naa a2200913 4500
001oai:DiVA.org:umu-88180
003SwePub
008140424s2014 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:128516338
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-881802 URI
0247 a https://doi.org/10.1002/ijc.285892 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1285163382 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Kaaks, Rudolf4 aut
2451 0a Insulin-like growth factor I and risk of breast cancer by age and hormone receptor status :b A prospective study within the EPIC cohort
264 c 2013-11-19
264 1b Wiley,c 2014
338 a print2 rdacarrier
520 a Experimental evidence shows cross-talk in mammary cells between estrogen, insulin-like growth factor I (IGF-I) and their respective receptors and possible synergistic effects of estrogen receptor (ER) activation and increased IGF-I signaling with regard to breast tumor development, and epidemiological evidence suggests that circulating IGF-I levels may be related more to the risk of ER-positive than ER-negative breast cancer. Using a case–control study nested within the prospective European EPIC cohort (938 breast cancer cases and 1,394 matched control subjects), we analyzed the relationships of prediagnostic serum IGF-I levels with the risk of estrogen and progesterone receptor-positive and -negative breast tumors. IGF-I levels were positively associated with the risk of ER+ breast tumors overall (pre- and postmenopausal women combined, odds ratio (OR)Q4-Q1 = 1.41 [95% confidence interval (CI) 1.01–1.98] for the highest vs. lowest quartile; OR = 1.17 [95% CI 1.04–1.33] per 1-standard deviation (SD) increase in IGF-I, ptrend = 0.01) and among women who were diagnosed with breast cancer at 50 years or older (ORQ3-Q1 = 1.38 [95% CI 1.01–1.89]; OR = 1.19 [95% CI 1.04–1.36] per 1-SD increase in IGF-I, ptrend = 0.01) but not with receptor-positive disease diagnosed at an earlier age. No statistically significant associations were observed for ER− breast tumors overall and by age at diagnosis. Tests for heterogeneity by receptor status of the tumor were not statistically significant, except for women diagnosed with breast cancer at 50 years or older (phet = 0.03 for ER+/PR+ vs. ER−/PR− disease). Our data add to a global body of evidence indicating that higher circulating IGF-I levels may increase risk specifically of receptor-positive, but not receptor-negative, breast cancer diagnosed at 50 years or older.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
653 a breast cancer
653 a estrogen receptor
653 a insulin-like growth factor I
653 a prospective cohort
653 a European Prospective Investigation into Cancer and Nutrition
7001 a Johnson, Theron4 aut
7001 a Tikk, Kaja4 aut
7001 a Sookthai, Disorn4 aut
7001 a Tjønneland, Anne4 aut
7001 a Roswall, Nina4 aut
7001 a Overvad, Kim4 aut
7001 a Clavel-Chapelon, Françoise4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Dossus, Laure4 aut
7001 a Rinaldi, Sabina4 aut
7001 a Romieu, Isabelle4 aut
7001 a Boeing, Heiner4 aut
7001 a Schütze, Madlen4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Lagiou, Pagona4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Palli, Domenico4 aut
7001 a Grioni, Sara4 aut
7001 a Tumino, Rosario4 aut
7001 a Sacerdote, Carlotta4 aut
7001 a Panico, Salvatore4 aut
7001 a Buckland, Genevieve4 aut
7001 a Argüelles, Marcial4 aut
7001 a Sánchez, María-José4 aut
7001 a Amiano, Pilar4 aut
7001 a Chirlaque, Maria-Dolores4 aut
7001 a Ardanaz, Eva4 aut
7001 a Bueno-de-Mesquita, H Bas4 aut
7001 a van Gils, Carla H4 aut
7001 a Peeters, Petra H4 aut
7001 a Andersson, Anneu Umeå universitet,Onkologi4 aut0 (Swepub:umu)ankr0012
7001 a Sund, Malin,d 1972-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Gram, Inger Torhild4 aut
7001 a Lund, Eiliv4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Wareham, Nick4 aut
7001 a Key, Timothy J4 aut
7001 a Travis, Ruth C4 aut
7001 a Merritt, Melissa A4 aut
7001 a Gunter, Marc J4 aut
7001 a Riboli, Elio4 aut
7001 a Lukanova, Annekatrinu Umeå universitet,Patologi4 aut0 (Swepub:umu)anlu0225
7102 a Umeå universitetb Onkologi4 org
7730 t International Journal of Cancerd : Wileyg 134:11, s. 2683-2690q 134:11<2683-2690x 0020-7136x 1097-0215
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.28589
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88180
8564 8u https://doi.org/10.1002/ijc.28589
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:128516338

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