Sökning: WFRF:(Merritt Melissa A) > (2014) > Insulin-like growth...
Fältnamn | Indikatorer | Metadata |
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000 | 05446naa a2200913 4500 | |
001 | oai:DiVA.org:umu-88180 | |
003 | SwePub | |
008 | 140424s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:128516338 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-881802 URI |
024 | 7 | a https://doi.org/10.1002/ijc.285892 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1285163382 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kaaks, Rudolf4 aut |
245 | 1 0 | a Insulin-like growth factor I and risk of breast cancer by age and hormone receptor status :b A prospective study within the EPIC cohort |
264 | c 2013-11-19 | |
264 | 1 | b Wiley,c 2014 |
338 | a print2 rdacarrier | |
520 | a Experimental evidence shows cross-talk in mammary cells between estrogen, insulin-like growth factor I (IGF-I) and their respective receptors and possible synergistic effects of estrogen receptor (ER) activation and increased IGF-I signaling with regard to breast tumor development, and epidemiological evidence suggests that circulating IGF-I levels may be related more to the risk of ER-positive than ER-negative breast cancer. Using a case–control study nested within the prospective European EPIC cohort (938 breast cancer cases and 1,394 matched control subjects), we analyzed the relationships of prediagnostic serum IGF-I levels with the risk of estrogen and progesterone receptor-positive and -negative breast tumors. IGF-I levels were positively associated with the risk of ER+ breast tumors overall (pre- and postmenopausal women combined, odds ratio (OR)Q4-Q1 = 1.41 [95% confidence interval (CI) 1.01–1.98] for the highest vs. lowest quartile; OR = 1.17 [95% CI 1.04–1.33] per 1-standard deviation (SD) increase in IGF-I, ptrend = 0.01) and among women who were diagnosed with breast cancer at 50 years or older (ORQ3-Q1 = 1.38 [95% CI 1.01–1.89]; OR = 1.19 [95% CI 1.04–1.36] per 1-SD increase in IGF-I, ptrend = 0.01) but not with receptor-positive disease diagnosed at an earlier age. No statistically significant associations were observed for ER− breast tumors overall and by age at diagnosis. Tests for heterogeneity by receptor status of the tumor were not statistically significant, except for women diagnosed with breast cancer at 50 years or older (phet = 0.03 for ER+/PR+ vs. ER−/PR− disease). Our data add to a global body of evidence indicating that higher circulating IGF-I levels may increase risk specifically of receptor-positive, but not receptor-negative, breast cancer diagnosed at 50 years or older. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
653 | a breast cancer | |
653 | a estrogen receptor | |
653 | a insulin-like growth factor I | |
653 | a prospective cohort | |
653 | a European Prospective Investigation into Cancer and Nutrition | |
700 | 1 | a Johnson, Theron4 aut |
700 | 1 | a Tikk, Kaja4 aut |
700 | 1 | a Sookthai, Disorn4 aut |
700 | 1 | a Tjønneland, Anne4 aut |
700 | 1 | a Roswall, Nina4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Clavel-Chapelon, Françoise4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christine4 aut |
700 | 1 | a Dossus, Laure4 aut |
700 | 1 | a Rinaldi, Sabina4 aut |
700 | 1 | a Romieu, Isabelle4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Schütze, Madlen4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Lagiou, Pagona4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Grioni, Sara4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Sacerdote, Carlotta4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Buckland, Genevieve4 aut |
700 | 1 | a Argüelles, Marcial4 aut |
700 | 1 | a Sánchez, María-José4 aut |
700 | 1 | a Amiano, Pilar4 aut |
700 | 1 | a Chirlaque, Maria-Dolores4 aut |
700 | 1 | a Ardanaz, Eva4 aut |
700 | 1 | a Bueno-de-Mesquita, H Bas4 aut |
700 | 1 | a van Gils, Carla H4 aut |
700 | 1 | a Peeters, Petra H4 aut |
700 | 1 | a Andersson, Anneu Umeå universitet,Onkologi4 aut0 (Swepub:umu)ankr0012 |
700 | 1 | a Sund, Malin,d 1972-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021 |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Gram, Inger Torhild4 aut |
700 | 1 | a Lund, Eiliv4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Wareham, Nick4 aut |
700 | 1 | a Key, Timothy J4 aut |
700 | 1 | a Travis, Ruth C4 aut |
700 | 1 | a Merritt, Melissa A4 aut |
700 | 1 | a Gunter, Marc J4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Lukanova, Annekatrinu Umeå universitet,Patologi4 aut0 (Swepub:umu)anlu0225 |
710 | 2 | a Umeå universitetb Onkologi4 org |
773 | 0 | t International Journal of Cancerd : Wileyg 134:11, s. 2683-2690q 134:11<2683-2690x 0020-7136x 1097-0215 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.28589 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88180 |
856 | 4 8 | u https://doi.org/10.1002/ijc.28589 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:128516338 |
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