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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004833naa a2200601 4500
001oai:lup.lub.lu.se:f7b25941-20c9-40ab-adc5-a3a9cc8161d6
003SwePub
008230706s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/f7b25941-20c9-40ab-adc5-a3a9cc8161d62 URI
0247 a https://doi.org/10.1016/j.xcrm.2023.1010932 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Nakayasu, Ernesto Su Pacific Northwest National Laboratory4 aut
2451 0a Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity
264 1c 2023
520 a Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study to identify biomarkers predictive of T1D development. Untargeted proteomics of 2,252 samples from 184 individuals identify 376 regulated proteins, showing alteration of complement, inflammatory signaling, and metabolic proteins even prior to autoimmunity onset. Extracellular matrix and antigen presentation proteins are differentially regulated in individuals who progress to T1D vs. those that remain in autoimmunity. Targeted proteomics measurements of 167 proteins in 6,426 samples from 990 individuals validate 83 biomarkers. A machine learning analysis predicts if individuals would remain in autoimmunity or develop T1D 6 months before autoantibody appearance, with areas under receiver operating characteristic curves of 0.871 and 0.918, respectively. Our study identifies and validates biomarkers, highlighting pathways affected during T1D development.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
7001 a Bramer, Lisa Mu Pacific Northwest National Laboratory4 aut
7001 a Ansong, Charlesu Pacific Northwest National Laboratory4 aut
7001 a Schepmoes, Athena Au Pacific Northwest National Laboratory4 aut
7001 a Fillmore, Thomas Lu Pacific Northwest National Laboratory4 aut
7001 a Gritsenko, Marina Au Pacific Northwest National Laboratory4 aut
7001 a Clauss, Therese Ru Pacific Northwest National Laboratory4 aut
7001 a Gao, Yuqianu Pacific Northwest National Laboratory4 aut
7001 a Piehowski, Paul Du Pacific Northwest National Laboratory4 aut
7001 a Stanfill, Bryan Au Pacific Northwest National Laboratory4 aut
7001 a Engel, Dave Wu Pacific Northwest National Laboratory4 aut
7001 a Orton, Daniel Ju Pacific Northwest National Laboratory4 aut
7001 a Moore, Ronald Ju Pacific Northwest National Laboratory4 aut
7001 a Qian, Wei-Junu Pacific Northwest National Laboratory4 aut
7001 a Sechi, Salvatoreu National Institutes of Health, United States4 aut
7001 a Frohnert, Brigitte Iu University of Colorado-Denver4 aut
7001 a Toppari, Jormau University of Turku,Turku University Hospital4 aut
7001 a Ziegler, Anette-Gu Technical University of Munich,Helmholtz Zentrum München4 aut
7001 a Lernmark, Åkeu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-ale
7001 a Hagopian, Williamu Pacific Northwest Research Institute4 aut
7001 a Akolkar, Beenau National Institutes of Health, United States4 aut
7001 a Smith, Richard Du Pacific Northwest National Laboratory4 aut
7001 a Rewers, Marian Ju University of Colorado-Denver4 aut
7001 a Webb-Robertson, Bobbie-Jo Mu Pacific Northwest National Laboratory4 aut
7001 a Metz, Thomas Ou Pacific Northwest National Laboratory4 aut
7102 a Pacific Northwest National Laboratoryb National Institutes of Health, United States4 org
7102 a TEDDY Study Group
7730 t Cell Reports Medicineg 4:7q 4:7x 2666-3791
8564 u http://dx.doi.org/10.1016/j.xcrm.2023.101093x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/f7b25941-20c9-40ab-adc5-a3a9cc8161d6
8564 8u https://doi.org/10.1016/j.xcrm.2023.101093

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