Comparative analysis of metazoan chromatin organization

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Fältnamn	Indikatorer	Metadata
000		06069naa a2201225 4500
001		oai:DiVA.org:umu-93483
003		SwePub
008		140923s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-934832 URI
024	7	a https://doi.org/10.1038/nature134152 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Ho, Joshua W. K.4 aut
245	1 0	a Comparative analysis of metazoan chromatin organization
264		c 2014-08-27
264	1	b Springer Science and Business Media LLC,c 2014
338		a print2 rdacarrier
520		a Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosophila melanogaster have contributed substantially to our understanding of molecular mechanisms of genome function in humans, and have revealed conservation of chromatin components and mechanisms(1-3). Nevertheless, the three organisms have markedly different genome sizes, chromosome architecture and gene organization. On human and fly chromosomes, for example, pericentric heterochromatin flanks single centromeres, whereas worm chromosomes have dispersed heterochromatin-like regions enriched in the distal chromosomal 'arms', and centromeres distributed along their lengths(4,5). To systematically investigate chromatin organization and associated gene regulation across species, we generated and analysed a large collection of genome-wide chromatin data sets from cell lines and developmental stages in worm, fly and human. Here we present over 800 new data sets from our ENCODE and modENCODE consortia, bringing the total to over 1,400. Comparison of combinatorial patterns of histone modifications, nuclear lamina-associated domains, organization of large-scale topological domains, chromatin environment at promoters and enhancers, nucleosome positioning, and DNA replication patterns reveals many conserved features of chromatin organization among the three organisms. We also find notable differences in the composition and locations of repressive chromatin. These data sets and analyses provide a rich resource for comparative and species-specific investigations of chromatin composition, organization and function.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
700	1	a June, Youngsook L.4 aut
700	1	a Liu, Tao4 aut
700	1	a Alver, Burak H.4 aut
700	1	a Lee, Soohyun4 aut
700	1	a Ikegami, Kohta4 aut
700	1	a Sohn, Kyung-Ah4 aut
700	1	a Minoda, Aki4 aut
700	1	a Tolstorukov, Michael Y.4 aut
700	1	a Appert, Alex4 aut
700	1	a Parker, Stephen C. J.4 aut
700	1	a Gu, Tingting4 aut
700	1	a Kundaje, Anshul4 aut
700	1	a Riddle, Nicole C.4 aut
700	1	a Bishop, Eric4 aut
700	1	a Egelhofer, Thea A.4 aut
700	1	a Hu, Sheng'en Shawn4 aut
700	1	a Alekseyenko, Artyom A.4 aut
700	1	a Rechtsteiner, Andreas4 aut
700	1	a Asker, Dalal4 aut
700	1	a Belsky, Jason A.4 aut
700	1	a Bowmanm, Sarah K.4 aut
700	1	a Chens, Q. Brent4 aut
700	1	a Chen, Ron A. -J.4 aut
700	1	a Day, Daniel S.4 aut
700	1	a Dong, Yan4 aut
700	1	a Dose, Andrea C.4 aut
700	1	a Duan, Xikun4 aut
700	1	a Epstein, Charles B.4 aut
700	1	a Ercan, Sevinc4 aut
700	1	a Feingold, Elise A.4 aut
700	1	a Ferrari, Francesco4 aut
700	1	a Garrigues, Jacob M.4 aut
700	1	a Gehlenborg, Nils4 aut
700	1	a Good, Peter J.4 aut
700	1	a Haseley, Psalm4 aut
700	1	a He, Daniel4 aut
700	1	a Herrmann, Moritz4 aut
700	1	a Hoffman, Michael M.4 aut
700	1	a Jeffers, Tess E.4 aut
700	1	a Kharchenko, Peter V.4 aut
700	1	a Kolasinska-Zwierz, Paulina4 aut
700	1	a Kotwaliwale, Chitra V.4 aut
700	1	a Kumar, Nischay4 aut
700	1	a Langley, Sasha A.4 aut
700	1	a Larschan, Erica N.4 aut
700	1	a Latorre, Isabel4 aut
700	1	a Libbrecht, Maxwell W.4 aut
700	1	a Lin, Xueqiu4 aut
700	1	a Park, Richard4 aut
700	1	a Pazin, Michael J.4 aut
700	1	a Pham, Hoang N.4 aut
700	1	a Plachetka, Annette4 aut
700	1	a Qin, Bo4 aut
700	1	a Schwartz, Yuri B.u Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)yusc0002
700	1	a Shoresh, Noam4 aut
700	1	a Stempor, Przemyslaw4 aut
700	1	a Vielle, Anne4 aut
700	1	a Wang, Chengyang4 aut
700	1	a Whittle, Christina M.4 aut
700	1	a Xue, Huiling4 aut
700	1	a Kingstonm, Robert E.4 aut
700	1	a Kim, Ju Han4 aut
700	1	a Bernstein, Bradley E.4 aut
700	1	a Dernburg, Abby F.4 aut
700	1	a Pirrotta, Vincenzo4 aut
700	1	a Kuroda, Mitzi I.4 aut
700	1	a Noble, William S.4 aut
700	1	a Tullius, Thomas D.4 aut
700	1	a Kellis, Manolis4 aut
700	1	a MacAlpine, David M.4 aut
700	1	a Strome, Susan4 aut
700	1	a Elgin, Sarah C. R.4 aut
700	1	a Liu, Xiaole Shirley4 aut
700	1	a Lieb, Jason D.4 aut
700	1	a Ahringer, Julie4 aut
700	1	a Karpen, Gary H.4 aut
700	1	a Park, Peter J.4 aut
710	2	a Umeå universitetb Institutionen för molekylärbiologi (Medicinska fakulteten)4 org
773	0	t Natured : Springer Science and Business Media LLCg 512:7515, s. 449-U507q 512:7515<449-U507x 0028-0836x 1476-4687
856	4	u https://www.nature.com/articles/nature13415.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-93483
856	4 8	u https://doi.org/10.1038/nature13415

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Av författaren/redakt...: Ho, Joshua W. K.; June, Youngsook ...; Liu, Tao; Alver, Burak H.; Lee, Soohyun; Ikegami, Kohta; visa fler...; Sohn, Kyung-Ah; Minoda, Aki; Tolstorukov, Mic ...; Appert, Alex; Parker, Stephen ...; Gu, Tingting; Kundaje, Anshul; Riddle, Nicole C ...; Bishop, Eric; Egelhofer, Thea ...; Hu, Sheng'en Sha ...; Alekseyenko, Art ...; Rechtsteiner, An ...; Asker, Dalal; Belsky, Jason A.; Bowmanm, Sarah K ...; Chens, Q. Brent; Chen, Ron A. -J.; Day, Daniel S.; Dong, Yan; Dose, Andrea C.; Duan, Xikun; Epstein, Charles ...; Ercan, Sevinc; Feingold, Elise ...; Ferrari, Frances ...; Garrigues, Jacob ...; Gehlenborg, Nils; Good, Peter J.; Haseley, Psalm; He, Daniel; Herrmann, Moritz; Hoffman, Michael ...; Jeffers, Tess E.; Kharchenko, Pete ...; Kolasinska-Zwier ...; Kotwaliwale, Chi ...; Kumar, Nischay; Langley, Sasha A ...; Larschan, Erica ...; Latorre, Isabel; Libbrecht, Maxwe ...; Lin, Xueqiu; Park, Richard; Pazin, Michael J ...; Pham, Hoang N.; Plachetka, Annet ...; Qin, Bo; Schwartz, Yuri B ...; Shoresh, Noam; Stempor, Przemys ...; Vielle, Anne; Wang, Chengyang; Whittle, Christi ...; Xue, Huiling; Kingstonm, Rober ...; Kim, Ju Han; Bernstein, Bradl ...; Dernburg, Abby F ...; Pirrotta, Vincen ...; Kuroda, Mitzi I.; Noble, William S ...; Tullius, Thomas ...; Kellis, Manolis; MacAlpine, David ...; Strome, Susan; Elgin, Sarah C. ...; Liu, Xiaole Shir ...; Lieb, Jason D.; Ahringer, Julie; Karpen, Gary H.; Park, Peter J.; visa färre...

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